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Lymphovascular invasion is an independent prognostic factor in prostatic adenocarcinoma.
J Urol. 2005 Dec; 174(6):2181-5.JU

Abstract

PURPOSE

Gleason grade and tumor stage are well established prognostic factors in prostate cancer. Histological demonstration of tumor in lymphovascular spaces has been associated with poor prognosis in many tumor types but it is not included in current prostate cancer grading and staging schemes. Whether lymphovascular invasion is an independent prognostic factor for disease progression in prostate cancer is uncertain. We retrospectively investigated lymphovascular invasion as a predictive factor for biochemical failure and cancer specific survival following radical prostatectomy.

MATERIALS AND METHODS

The records of 504 patients with prostatic adenocarcinoma undergoing radical prostatectomy were reviewed for lymphovascular invasion. Clinical followup data were available on 459 cases. Mean followup was 44 months (range 1.5 to 144). Multivariate analysis was performed using the Cox model.

RESULTS

Lymphovascular invasion was identified in 106 cases (21%). Univariate analysis showed a significant association between lymphovascular invasion and higher preoperative serum prostate specific antigen (PSA), advanced pathological stage, higher Gleason score, positive surgical margins, extraprostatic extension, seminal vesicle invasion, lymph node metastasis and perineural invasion (each p <0.001). No association was observed between lymphovascular invasion and patient age at surgery, prostate weight or high grade prostatic intraepithelial neoplasia. Lymphovascular invasion was an independent predictor of PSA recurrence (HR 1.6, 95% CI 1.12 to 2.38, p = 0.01) and cancer specific survival (HR 2.75, 95% CI 1.04 to 2.28, p = 0.041) after controlling for tumor stage, surgical margins and Gleason grade on multivariate analysis. Five-year cancer specific survival was 90% in men with lymphovascular invasion compared to 98% in those without lymphovascular invasion (p <0.001).

CONCLUSIONS

Lymphovascular invasion can be identified in approximately 20% of prostate cancer cases. Lymphovascular invasion is an independent risk factor for PSA recurrence and cancer death in patients with prostate cancer.

Authors+Show Affiliations

Cheng L
Departments of Pathology and Laboratory Medicine, Indiana University School of Medicine, Medical Center, University Hospital 3465, 550 North University Boulevard, Indianapolis, IN 46202, USA. lcheng@iupui.edu
Jones TD
No affiliation info available
Lin H
No affiliation info available
Eble JN
No affiliation info available
Zeng G
No affiliation info available
Carr MD
No affiliation info available
Koch MO
No affiliation info available

MeSH

AdenocarcinomaAdultAgedAged, 80 and overBiomarkers, TumorDisease-Free SurvivalFollow-Up StudiesHumansLymphatic MetastasisLymphatic VesselsMaleMedical RecordsMiddle AgedMultivariate AnalysisNeoplasm InvasivenessNeoplasm Recurrence, LocalNeoplasm StagingPredictive Value of TestsPrognosisProportional Hazards ModelsProstate-Specific AntigenProstatectomyProstatic NeoplasmsRetrospective StudiesTreatment Outcome

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16280760

Citation

Cheng, Liang, et al. "Lymphovascular Invasion Is an Independent Prognostic Factor in Prostatic Adenocarcinoma." The Journal of Urology, vol. 174, no. 6, 2005, pp. 2181-5.
Cheng L, Jones TD, Lin H, et al. Lymphovascular invasion is an independent prognostic factor in prostatic adenocarcinoma. J Urol. 2005;174(6):2181-5.
Cheng, L., Jones, T. D., Lin, H., Eble, J. N., Zeng, G., Carr, M. D., & Koch, M. O. (2005). Lymphovascular invasion is an independent prognostic factor in prostatic adenocarcinoma. The Journal of Urology, 174(6), 2181-5.
Cheng L, et al. Lymphovascular Invasion Is an Independent Prognostic Factor in Prostatic Adenocarcinoma. J Urol. 2005;174(6):2181-5. PubMed PMID: 16280760.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lymphovascular invasion is an independent prognostic factor in prostatic adenocarcinoma. AU - Cheng,Liang, AU - Jones,Timothy D, AU - Lin,Haiqun, AU - Eble,John N, AU - Zeng,Gordon, AU - Carr,Matthew D, AU - Koch,Michael O, PY - 2005/11/11/pubmed PY - 2006/9/16/medline PY - 2005/11/11/entrez SP - 2181 EP - 5 JF - The Journal of urology JO - J Urol VL - 174 IS - 6 N2 - PURPOSE: Gleason grade and tumor stage are well established prognostic factors in prostate cancer. Histological demonstration of tumor in lymphovascular spaces has been associated with poor prognosis in many tumor types but it is not included in current prostate cancer grading and staging schemes. Whether lymphovascular invasion is an independent prognostic factor for disease progression in prostate cancer is uncertain. We retrospectively investigated lymphovascular invasion as a predictive factor for biochemical failure and cancer specific survival following radical prostatectomy. MATERIALS AND METHODS: The records of 504 patients with prostatic adenocarcinoma undergoing radical prostatectomy were reviewed for lymphovascular invasion. Clinical followup data were available on 459 cases. Mean followup was 44 months (range 1.5 to 144). Multivariate analysis was performed using the Cox model. RESULTS: Lymphovascular invasion was identified in 106 cases (21%). Univariate analysis showed a significant association between lymphovascular invasion and higher preoperative serum prostate specific antigen (PSA), advanced pathological stage, higher Gleason score, positive surgical margins, extraprostatic extension, seminal vesicle invasion, lymph node metastasis and perineural invasion (each p <0.001). No association was observed between lymphovascular invasion and patient age at surgery, prostate weight or high grade prostatic intraepithelial neoplasia. Lymphovascular invasion was an independent predictor of PSA recurrence (HR 1.6, 95% CI 1.12 to 2.38, p = 0.01) and cancer specific survival (HR 2.75, 95% CI 1.04 to 2.28, p = 0.041) after controlling for tumor stage, surgical margins and Gleason grade on multivariate analysis. Five-year cancer specific survival was 90% in men with lymphovascular invasion compared to 98% in those without lymphovascular invasion (p <0.001). CONCLUSIONS: Lymphovascular invasion can be identified in approximately 20% of prostate cancer cases. Lymphovascular invasion is an independent risk factor for PSA recurrence and cancer death in patients with prostate cancer. SN - 0022-5347 UR - https://www.unboundmedicine.com/medline/citation/16280760/Lymphovascular_invasion_is_an_independent_prognostic_factor_in_prostatic_adenocarcinoma_ DB - PRIME DP - Unbound Medicine ER -