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Association of depression with markers of nutrition and inflammation in chronic kidney disease and end-stage renal disease.

Abstract

BACKGROUND

Depression, which is the most common psychological disorder among patients with end-stage renal disease (ESRD), is commonly associated with poor oral intake which can aggravate anemia and malnutrition in chronic dialysis patients. The objective of this study is to explore the association between depression and C-reactive protein (CRP), ferritin, serum albumin and hemoglobin/hematocrit in patients with chronic kidney disease (CKD) and ESRD.

METHODS

Sixty-eight patients on hemodialysis (HD), 47 patients on continuous ambulatory peritoneal dialysis (CAPD) and 26 patients with CKD on conservative management were enrolled in this study. All patients were evaluated for the presence of depression using the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) Axis I Disorders-Clinician Version (SCID-CV). The severity of depression was evaluated by means of the Beck Depression Inventory (BDI). Serum CRP (nephelometric method), ferritin (immunometric method), albumin (bromcresol green technique), hemoglobin, and hematocrit levels were measured.

RESULTS

A total of 34 of 141 patients (24.1%) had depression. The mean BDI score was higher in depressive patients compared to nondepressive patients. In HD patients the frequency of depression and CRP and ferritin levels were higher than in other groups. Patients with depression had lower hemoglobin, hematocrit and serum albumin levels and higher CRP and ferritin levels than patients without depression. The BDI score showed a positive correlation with serum CRP and ferritin levels, but a negative correlation with the serum albumin level.

CONCLUSIONS

We observed that CKD and ESRD patients with anemia, hypoalbuminemia and higher serum CRP and ferritin concentrations should be evaluated for depression after potential somatic causes have been eliminated.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Division of Nephrology, Faculty of Medicine, University of Kocaeli, Kocaeli, Turkey. betul@petekmail.com

    ,

    Source

    Nephron. Clinical practice 102:3-4 2006 pg c115-21

    MeSH

    C-Reactive Protein
    Chronic Disease
    Depression
    Female
    Ferritins
    Hemoglobins
    Humans
    Inflammation
    Kidney Diseases
    Kidney Failure, Chronic
    Male
    Middle Aged
    Nutritional Status
    Peritoneal Dialysis, Continuous Ambulatory
    Prospective Studies
    Renal Dialysis
    Serum Albumin

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    16282695

    Citation

    Kalender, Betül, et al. "Association of Depression With Markers of Nutrition and Inflammation in Chronic Kidney Disease and End-stage Renal Disease." Nephron. Clinical Practice, vol. 102, no. 3-4, 2006, pp. c115-21.
    Kalender B, Ozdemir AC, Koroglu G. Association of depression with markers of nutrition and inflammation in chronic kidney disease and end-stage renal disease. Nephron Clin Pract. 2006;102(3-4):c115-21.
    Kalender, B., Ozdemir, A. C., & Koroglu, G. (2006). Association of depression with markers of nutrition and inflammation in chronic kidney disease and end-stage renal disease. Nephron. Clinical Practice, 102(3-4), pp. c115-21.
    Kalender B, Ozdemir AC, Koroglu G. Association of Depression With Markers of Nutrition and Inflammation in Chronic Kidney Disease and End-stage Renal Disease. Nephron Clin Pract. 2006;102(3-4):c115-21. PubMed PMID: 16282695.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Association of depression with markers of nutrition and inflammation in chronic kidney disease and end-stage renal disease. AU - Kalender,Betül, AU - Ozdemir,Aytul Corapcioglu, AU - Koroglu,Gulturk, Y1 - 2005/11/10/ PY - 2005/01/25/received PY - 2005/06/27/accepted PY - 2005/11/12/pubmed PY - 2006/7/14/medline PY - 2005/11/12/entrez SP - c115 EP - 21 JF - Nephron. Clinical practice JO - Nephron Clin Pract VL - 102 IS - 3-4 N2 - BACKGROUND: Depression, which is the most common psychological disorder among patients with end-stage renal disease (ESRD), is commonly associated with poor oral intake which can aggravate anemia and malnutrition in chronic dialysis patients. The objective of this study is to explore the association between depression and C-reactive protein (CRP), ferritin, serum albumin and hemoglobin/hematocrit in patients with chronic kidney disease (CKD) and ESRD. METHODS: Sixty-eight patients on hemodialysis (HD), 47 patients on continuous ambulatory peritoneal dialysis (CAPD) and 26 patients with CKD on conservative management were enrolled in this study. All patients were evaluated for the presence of depression using the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) Axis I Disorders-Clinician Version (SCID-CV). The severity of depression was evaluated by means of the Beck Depression Inventory (BDI). Serum CRP (nephelometric method), ferritin (immunometric method), albumin (bromcresol green technique), hemoglobin, and hematocrit levels were measured. RESULTS: A total of 34 of 141 patients (24.1%) had depression. The mean BDI score was higher in depressive patients compared to nondepressive patients. In HD patients the frequency of depression and CRP and ferritin levels were higher than in other groups. Patients with depression had lower hemoglobin, hematocrit and serum albumin levels and higher CRP and ferritin levels than patients without depression. The BDI score showed a positive correlation with serum CRP and ferritin levels, but a negative correlation with the serum albumin level. CONCLUSIONS: We observed that CKD and ESRD patients with anemia, hypoalbuminemia and higher serum CRP and ferritin concentrations should be evaluated for depression after potential somatic causes have been eliminated. SN - 1660-2110 UR - https://www.unboundmedicine.com/medline/citation/16282695/Association_of_depression_with_markers_of_nutrition_and_inflammation_in_chronic_kidney_disease_and_end_stage_renal_disease_ L2 - https://www.karger.com?DOI=10.1159/000089669 DB - PRIME DP - Unbound Medicine ER -