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Synthesis, characterization, and degradation behavior of amphiphilic poly-alpha,beta-[N-(2-hydroxyethyl)-L-aspartamide]-g-poly(epsilon-caprolactone).
Biomacromolecules 2005 Nov-Dec; 6(6):3449-57B

Abstract

A series of biodegradable amphiphilic graft polymers were successfully synthesized by grafting poly(epsilon-caprolactone) (PCL) sequences onto a water-soluble poly-alpha,beta-[N-(2-hydroxyethyl)-L-aspartamide] (PHEA) backbone. The graft copolymers were prepared through the ring-opening polymerization of epsilon-caprolactone (CL) initiated by the macroinitiator PHEA with pendant hydroxyl groups without adding any catalyst. By controlling the feed ratio of the macroinitiator to the monomer, the copolymers with different branch lengths and properties can be obtained. The successful grafting of PCL sequences onto the PHEA backbone was verified by FTIR, 1H NMR, and combined size-exclusion chromatography and multiangle laser light scattering (SEC-MALLS) analysis. The hydrolytic degradation and enzymatic degradation of these graft copolymers were investigated. The results show the hydrolytic degradation rate increases with increasing content of hydrophilic PHEA backbone. While the enzymatic degradation rate is affected by two competitive factors, the catalytic effect of Pseudomonas cepacia lipase on the degradation of PCL branches and the hydrophilicity which depends on the copolymer composition. In situ observation of the degradation under polarizing light microscope (PLM) demonstrates the different degradation rates of different regions in the polymer samples.

Authors+Show Affiliations

Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University, Wuhan 430072, People's Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16283778

Citation

Miao, Zhi-Mei, et al. "Synthesis, Characterization, and Degradation Behavior of Amphiphilic Poly-alpha,beta-[N-(2-hydroxyethyl)-L-aspartamide]-g-poly(epsilon-caprolactone)." Biomacromolecules, vol. 6, no. 6, 2005, pp. 3449-57.
Miao ZM, Cheng SX, Zhang XZ, et al. Synthesis, characterization, and degradation behavior of amphiphilic poly-alpha,beta-[N-(2-hydroxyethyl)-L-aspartamide]-g-poly(epsilon-caprolactone). Biomacromolecules. 2005;6(6):3449-57.
Miao, Z. M., Cheng, S. X., Zhang, X. Z., & Zhuo, R. X. (2005). Synthesis, characterization, and degradation behavior of amphiphilic poly-alpha,beta-[N-(2-hydroxyethyl)-L-aspartamide]-g-poly(epsilon-caprolactone). Biomacromolecules, 6(6), pp. 3449-57.
Miao ZM, et al. Synthesis, Characterization, and Degradation Behavior of Amphiphilic Poly-alpha,beta-[N-(2-hydroxyethyl)-L-aspartamide]-g-poly(epsilon-caprolactone). Biomacromolecules. 2005;6(6):3449-57. PubMed PMID: 16283778.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Synthesis, characterization, and degradation behavior of amphiphilic poly-alpha,beta-[N-(2-hydroxyethyl)-L-aspartamide]-g-poly(epsilon-caprolactone). AU - Miao,Zhi-Mei, AU - Cheng,Si-Xue, AU - Zhang,Xian-Zheng, AU - Zhuo,Ren-Xi, PY - 2005/11/15/pubmed PY - 2006/2/8/medline PY - 2005/11/15/entrez SP - 3449 EP - 57 JF - Biomacromolecules JO - Biomacromolecules VL - 6 IS - 6 N2 - A series of biodegradable amphiphilic graft polymers were successfully synthesized by grafting poly(epsilon-caprolactone) (PCL) sequences onto a water-soluble poly-alpha,beta-[N-(2-hydroxyethyl)-L-aspartamide] (PHEA) backbone. The graft copolymers were prepared through the ring-opening polymerization of epsilon-caprolactone (CL) initiated by the macroinitiator PHEA with pendant hydroxyl groups without adding any catalyst. By controlling the feed ratio of the macroinitiator to the monomer, the copolymers with different branch lengths and properties can be obtained. The successful grafting of PCL sequences onto the PHEA backbone was verified by FTIR, 1H NMR, and combined size-exclusion chromatography and multiangle laser light scattering (SEC-MALLS) analysis. The hydrolytic degradation and enzymatic degradation of these graft copolymers were investigated. The results show the hydrolytic degradation rate increases with increasing content of hydrophilic PHEA backbone. While the enzymatic degradation rate is affected by two competitive factors, the catalytic effect of Pseudomonas cepacia lipase on the degradation of PCL branches and the hydrophilicity which depends on the copolymer composition. In situ observation of the degradation under polarizing light microscope (PLM) demonstrates the different degradation rates of different regions in the polymer samples. SN - 1525-7797 UR - https://www.unboundmedicine.com/medline/citation/16283778/Synthesis_characterization_and_degradation_behavior_of_amphiphilic_poly_alphabeta_[N__2_hydroxyethyl__L_aspartamide]_g_poly_epsilon_caprolactone__ L2 - https://dx.doi.org/10.1021/bm050551n DB - PRIME DP - Unbound Medicine ER -