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Long-term repetitive sodium lauryl sulfate-induced irritation of the skin: an in vivo study.
Contact Dermatitis. 2005 Nov; 53(5):278-84.CD

Abstract

Skin may adapt to topical irritants through accommodation. This study focuses on long-term exposure to irritants and attempts to demonstrate accommodation. Sodium lauryl sulfate (SLS) induced irritant contact dermatitis at 3 concentrations (0.025% to 0.075%). Distilled water, acetone and an empty chamber served as controls. Experimental compounds were applied to forearms of 7 healthy volunteers for 24 hr before replacing by a fresh chamber for 6 non-consecutive weeks over 103 days. Possible accommodation was quantified by visual scoring (erythema and dryness) and by bioengineering parameters: transepidermal water loss (TEWL), capacitance, chromametry and laser Doppler flowmetry (LDF). Significant erythema, dryness, elevated TEWL, skin colour reflectance and LDF values occurred during the exposure periods. Upon repeat exposure, an immediate and augmented response in erythema, TEWL, skin colour reflectance and LDF developed. However, irritant skin changes were not sustained. Irritation parameters return to baseline after cessation of exposure. There was no evidence of sustained irritation or accommodation after the last exposure. Study findings do not document sustained accommodation or adaptive hyposensitivity after long-term repetitive irritant exposure under these test conditions. Alternative models should be developed to prove or disprove the accommodation hypothesis.

Authors+Show Affiliations

Branco N
Department of Dermatology, University of California, School of Medicine, San Francisco, CA 94143-0989, USA.
Lee I
No affiliation info available
Zhai H
No affiliation info available
Maibach HI
No affiliation info available

MeSH

Adaptation, PhysiologicalAdultAnalysis of VarianceBiomedical EngineeringDermatitis, IrritantDose-Response Relationship, ImmunologicFemaleHumansMaleMiddle AgedSkinSkin Physiological PhenomenaSkin TestsSodium Dodecyl SulfateSurface-Active AgentsTime FactorsWater Loss, Insensible

Pub Type(s)

Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

16283906

Citation

Branco, Nara, et al. "Long-term Repetitive Sodium Lauryl Sulfate-induced Irritation of the Skin: an in Vivo Study." Contact Dermatitis, vol. 53, no. 5, 2005, pp. 278-84.
Branco N, Lee I, Zhai H, et al. Long-term repetitive sodium lauryl sulfate-induced irritation of the skin: an in vivo study. Contact Dermatitis. 2005;53(5):278-84.
Branco, N., Lee, I., Zhai, H., & Maibach, H. I. (2005). Long-term repetitive sodium lauryl sulfate-induced irritation of the skin: an in vivo study. Contact Dermatitis, 53(5), 278-84.
Branco N, et al. Long-term Repetitive Sodium Lauryl Sulfate-induced Irritation of the Skin: an in Vivo Study. Contact Dermatitis. 2005;53(5):278-84. PubMed PMID: 16283906.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-term repetitive sodium lauryl sulfate-induced irritation of the skin: an in vivo study. AU - Branco,Nara, AU - Lee,Ivy, AU - Zhai,Hongbo, AU - Maibach,Howard I, PY - 2005/11/15/pubmed PY - 2006/2/8/medline PY - 2005/11/15/entrez SP - 278 EP - 84 JF - Contact dermatitis JO - Contact Dermatitis VL - 53 IS - 5 N2 - Skin may adapt to topical irritants through accommodation. This study focuses on long-term exposure to irritants and attempts to demonstrate accommodation. Sodium lauryl sulfate (SLS) induced irritant contact dermatitis at 3 concentrations (0.025% to 0.075%). Distilled water, acetone and an empty chamber served as controls. Experimental compounds were applied to forearms of 7 healthy volunteers for 24 hr before replacing by a fresh chamber for 6 non-consecutive weeks over 103 days. Possible accommodation was quantified by visual scoring (erythema and dryness) and by bioengineering parameters: transepidermal water loss (TEWL), capacitance, chromametry and laser Doppler flowmetry (LDF). Significant erythema, dryness, elevated TEWL, skin colour reflectance and LDF values occurred during the exposure periods. Upon repeat exposure, an immediate and augmented response in erythema, TEWL, skin colour reflectance and LDF developed. However, irritant skin changes were not sustained. Irritation parameters return to baseline after cessation of exposure. There was no evidence of sustained irritation or accommodation after the last exposure. Study findings do not document sustained accommodation or adaptive hyposensitivity after long-term repetitive irritant exposure under these test conditions. Alternative models should be developed to prove or disprove the accommodation hypothesis. SN - 0105-1873 UR - https://www.unboundmedicine.com/medline/citation/16283906/Long_term_repetitive_sodium_lauryl_sulfate_induced_irritation_of_the_skin:_an_in_vivo_study_ DB - PRIME DP - Unbound Medicine ER -