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Fruit and vegetable consumption and risk of epithelial ovarian cancer: the European Prospective Investigation into Cancer and Nutrition.

Abstract

OBJECTIVE

The association between consumption of fruit and vegetables and risk of ovarian cancer is still unclear from a prospective point of view.

METHODS

Female participants (n = 325,640) of the European Prospective Investigation into Cancer and Nutrition study, free of any cancer at baseline, were followed on average for 6.3 years to develop ovarian cancer. During 2,049,346 person-years, 581 verified cases of primary, invasive epithelial ovarian cancer were accrued. Consumption of fruits and vegetables as well as subgroups of vegetables, estimated from validated dietary questionnaires and calibrated thereafter, was related to ovarian cancer incidence in multivariable hazard regression models. Histologic subtype specific analyses were done.

RESULTS

Total intake of fruit and vegetables, separately or combined, as well as subgroups of vegetables (fruiting, root, leafy vegetables, cabbages) was unrelated to risk of ovarian cancer. A high intake of garlic/onion vegetables was associated with a borderline significant reduced risk of this cancer. The examination by histologic subtype indicated some differential effects of fruit and vegetable intake on ovarian cancer risk.

CONCLUSION

Overall, a high intake of fruits and vegetables did not seem to protect from ovarian cancer. Garlic/onion vegetables may exert a beneficial effect. The study of the histologic subtype of the tumor warrants further investigation.

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  • Authors+Show Affiliations

    ,

    German Institute of Human Nutrition Potsdam-Rehbrücke, Arthur-Scheunert-Allee 114-116, 14458 Nuthetal, Germany. mschulz@mail.dife.de

    , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,

    Source

    MeSH

    Adult
    Aged
    Diet
    Epidemiologic Studies
    Europe
    Female
    Fruit
    Humans
    Incidence
    Life Style
    Middle Aged
    Nutrition Surveys
    Ovarian Neoplasms
    Prospective Studies
    Risk Factors
    Vegetables

    Pub Type(s)

    Journal Article
    Multicenter Study
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    16284374

    Citation

    Schulz, Mandy, et al. "Fruit and Vegetable Consumption and Risk of Epithelial Ovarian Cancer: the European Prospective Investigation Into Cancer and Nutrition." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 14, no. 11 Pt 1, 2005, pp. 2531-5.
    Schulz M, Lahmann PH, Boeing H, et al. Fruit and vegetable consumption and risk of epithelial ovarian cancer: the European Prospective Investigation into Cancer and Nutrition. Cancer Epidemiol Biomarkers Prev. 2005;14(11 Pt 1):2531-5.
    Schulz, M., Lahmann, P. H., Boeing, H., Hoffmann, K., Allen, N., Key, T. J., ... Riboli, E. (2005). Fruit and vegetable consumption and risk of epithelial ovarian cancer: the European Prospective Investigation into Cancer and Nutrition. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 14(11 Pt 1), pp. 2531-5.
    Schulz M, et al. Fruit and Vegetable Consumption and Risk of Epithelial Ovarian Cancer: the European Prospective Investigation Into Cancer and Nutrition. Cancer Epidemiol Biomarkers Prev. 2005;14(11 Pt 1):2531-5. PubMed PMID: 16284374.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Fruit and vegetable consumption and risk of epithelial ovarian cancer: the European Prospective Investigation into Cancer and Nutrition. AU - Schulz,Mandy, AU - Lahmann,Petra H, AU - Boeing,Heiner, AU - Hoffmann,Kurt, AU - Allen,Naomi, AU - Key,Timothy J A, AU - Bingham,Sheila, AU - Wirfält,Elisabet, AU - Berglund,Göran, AU - Lundin,Eva, AU - Hallmans,Göran, AU - Lukanova,Annekatrin, AU - Martínez Garcia,Carmen, AU - González,Carlos A, AU - Tormo,Maria J, AU - Quirós,José R, AU - Ardanaz,Eva, AU - Larrañaga,Nerea, AU - Lund,Eiliv, AU - Gram,Inger T, AU - Skeie,Guri, AU - Peeters,Petra H M, AU - van Gils,Carla H, AU - Bueno-de-Mesquita,H Bas, AU - Büchner,Frederike L, AU - Pasanisi,Patrizia, AU - Galasso,Rocco, AU - Palli,Domenico, AU - Tumino,Rosario, AU - Vineis,Paolo, AU - Trichopoulou,Antonia, AU - Kalapothaki,Victoria, AU - Trichopoulos,Dimitrios, AU - Chang-Claude,Jenny, AU - Linseisen,Jakob, AU - Boutron-Ruault,Marie Christine, AU - Touillaud,Marina, AU - Clavel-Chapelon,Françoise, AU - Olsen,Anja, AU - Tjønneland,Anne, AU - Overvad,Kim, AU - Tetsche,Mette, AU - Jenab,Mazda, AU - Norat,Teresa, AU - Kaaks,Rudolph, AU - Riboli,Elio, PY - 2005/11/15/pubmed PY - 2006/1/13/medline PY - 2005/11/15/entrez SP - 2531 EP - 5 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 14 IS - 11 Pt 1 N2 - OBJECTIVE: The association between consumption of fruit and vegetables and risk of ovarian cancer is still unclear from a prospective point of view. METHODS: Female participants (n = 325,640) of the European Prospective Investigation into Cancer and Nutrition study, free of any cancer at baseline, were followed on average for 6.3 years to develop ovarian cancer. During 2,049,346 person-years, 581 verified cases of primary, invasive epithelial ovarian cancer were accrued. Consumption of fruits and vegetables as well as subgroups of vegetables, estimated from validated dietary questionnaires and calibrated thereafter, was related to ovarian cancer incidence in multivariable hazard regression models. Histologic subtype specific analyses were done. RESULTS: Total intake of fruit and vegetables, separately or combined, as well as subgroups of vegetables (fruiting, root, leafy vegetables, cabbages) was unrelated to risk of ovarian cancer. A high intake of garlic/onion vegetables was associated with a borderline significant reduced risk of this cancer. The examination by histologic subtype indicated some differential effects of fruit and vegetable intake on ovarian cancer risk. CONCLUSION: Overall, a high intake of fruits and vegetables did not seem to protect from ovarian cancer. Garlic/onion vegetables may exert a beneficial effect. The study of the histologic subtype of the tumor warrants further investigation. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/16284374/Fruit_and_vegetable_consumption_and_risk_of_epithelial_ovarian_cancer:_the_European_Prospective_Investigation_into_Cancer_and_Nutrition_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=16284374 DB - PRIME DP - Unbound Medicine ER -