Tags

Type your tag names separated by a space and hit enter

Transdermal fentanyl versus sustained release oral morphine in strong-opioid naïve patients with chronic low back pain.
Spine (Phila Pa 1976). 2005 Nov 15; 30(22):2484-90.S

Abstract

STUDY DESIGN

Open, randomized, parallel group multicenter study.

OBJECTIVES

To compare the efficacy and safety of transdermal fentanyl (TDF) and sustained release morphine (SRM) in strong-opioid naïve patients with chronic low back pain (CLBP).

SUMMARY OF BACKGROUND DATA

Most studies of TDF and SRM have involved patients already receiving strong opioids. This is the first large-scale study focusing on strong-opioid naïve patients with CLBP.

METHODS

Adults with CLBP requiring regular strong opioid therapy received either TDF or SRM for 13 months. Starting doses were 25 microg/hr fentanyl patches every 72 hours or 30 mg oral morphine every 12 hours. Doses were adjusted according to response. Participants assessed pain relief and bowel function using weekly diaries. Other assessments, including quality of life, disease progression, and side effects, were made by patients and investigators.

RESULTS

Data from 680 patients showed that TDF and SRM provided similar levels of pain relief, but TDF was associated with significantly less constipation than SRM, indicating a greater likelihood of satisfactory pain relief without unmanageable constipation for patients receiving TDF. Other ratings were similar for TDF and SRM, but TDF provided greater relief of pain at rest and at night.

CONCLUSIONS

TDF and SRM provided equivalent levels of pain relief, but TDF was associated with less constipation. This study indicates that sustained-release strong opioids can safely be used in strong-opioid naïve patients.

Authors+Show Affiliations

Northwick Park & St. Marks NHS Trust, Harrow, Middlesex, UK. laurie.allan@datacam.netNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16284584

Citation

Allan, Laurie, et al. "Transdermal Fentanyl Versus Sustained Release Oral Morphine in Strong-opioid Naïve Patients With Chronic Low Back Pain." Spine, vol. 30, no. 22, 2005, pp. 2484-90.
Allan L, Richarz U, Simpson K, et al. Transdermal fentanyl versus sustained release oral morphine in strong-opioid naïve patients with chronic low back pain. Spine (Phila Pa 1976). 2005;30(22):2484-90.
Allan, L., Richarz, U., Simpson, K., & Slappendel, R. (2005). Transdermal fentanyl versus sustained release oral morphine in strong-opioid naïve patients with chronic low back pain. Spine, 30(22), 2484-90.
Allan L, et al. Transdermal Fentanyl Versus Sustained Release Oral Morphine in Strong-opioid Naïve Patients With Chronic Low Back Pain. Spine (Phila Pa 1976). 2005 Nov 15;30(22):2484-90. PubMed PMID: 16284584.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Transdermal fentanyl versus sustained release oral morphine in strong-opioid naïve patients with chronic low back pain. AU - Allan,Laurie, AU - Richarz,Ute, AU - Simpson,Karen, AU - Slappendel,Robert, PY - 2005/11/15/pubmed PY - 2006/2/9/medline PY - 2005/11/15/entrez SP - 2484 EP - 90 JF - Spine JO - Spine (Phila Pa 1976) VL - 30 IS - 22 N2 - STUDY DESIGN: Open, randomized, parallel group multicenter study. OBJECTIVES: To compare the efficacy and safety of transdermal fentanyl (TDF) and sustained release morphine (SRM) in strong-opioid naïve patients with chronic low back pain (CLBP). SUMMARY OF BACKGROUND DATA: Most studies of TDF and SRM have involved patients already receiving strong opioids. This is the first large-scale study focusing on strong-opioid naïve patients with CLBP. METHODS: Adults with CLBP requiring regular strong opioid therapy received either TDF or SRM for 13 months. Starting doses were 25 microg/hr fentanyl patches every 72 hours or 30 mg oral morphine every 12 hours. Doses were adjusted according to response. Participants assessed pain relief and bowel function using weekly diaries. Other assessments, including quality of life, disease progression, and side effects, were made by patients and investigators. RESULTS: Data from 680 patients showed that TDF and SRM provided similar levels of pain relief, but TDF was associated with significantly less constipation than SRM, indicating a greater likelihood of satisfactory pain relief without unmanageable constipation for patients receiving TDF. Other ratings were similar for TDF and SRM, but TDF provided greater relief of pain at rest and at night. CONCLUSIONS: TDF and SRM provided equivalent levels of pain relief, but TDF was associated with less constipation. This study indicates that sustained-release strong opioids can safely be used in strong-opioid naïve patients. SN - 1528-1159 UR - https://www.unboundmedicine.com/medline/citation/16284584/Transdermal_fentanyl_versus_sustained_release_oral_morphine_in_strong_opioid_naïve_patients_with_chronic_low_back_pain_ L2 - https://doi.org/10.1097/01.brs.0000186860.23078.a8 DB - PRIME DP - Unbound Medicine ER -