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Time course of total and food specific IgE antibodies (Rast Fx5) in the developing allergic child.
Eur Ann Allergy Clin Immunol. 2005 Sep; 37(7):257-61.EA

Abstract

AIM

To analyze the evolution of total and food specific IgE (Rast Fx5) titers in the course of food allergy in children.

PATIENTS & METHODS

925 children, mean age 8.9 + 9.1 years (15 days-18 years), 455 girls and 470 boys, investigated for food allergy in year 1997, underwent serum samples assay for total IgE and of Rast Fx5, Cap System, Pharmacia & Upjohn Diagnostics AB, Uppsala, Sweden, a mix test detecting specific IgE to 6 major food allergens in children, cow's milk proteins (CMP), egg white, peanut, soy, wheat and fish and analyzed as a function of reference values by age.

RESULTS

Total IgE titers increased significantly with age, r0.22, p0.0001. The percentage of children with a total IgE level above normal range first increased with age, from 10.3 % at 0-6 months, reaching 38.2 % at 1-2 years and peaking at 56.9% at 4-6 years, then leveled off, 48.1% at 8-12 years (ns vs 4-6 years) and 41.3% above 12 years (ns). Detectable Rast Fx5 increased in a parallel manner until age 4-6 years and then exhibited a progressive decrease from age 6-8 years, differing significantly from total IgE: 31.9% vs 52.9%, p0.01 (6-8 years), 32.2% vs 48.1%, p0.03 (8-12 years), 21.8% vs 41.3%, p0.05 (> 12 years).

CONCLUSION

In these outpatient children investigated for food allergy, the increase with age of the percentage of high total IgE contrasted with the progressive decrease of Rast Fx5 from age 4-6 yr. This biological finding correlates timely with the clinical spontaneous decrease of food allergy in the developing child.

Authors+Show Affiliations

Department of Pediatrics, Neonatology, Pediatric Gastroenterology & Nutrition Unit, Hôpital Cochin-Saint Vincent de Paul, Paris, France. kalach.nicolas@ghicl.netNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16285230

Citation

Kalach, Nicolas, et al. "Time Course of Total and Food Specific IgE Antibodies (Rast Fx5) in the Developing Allergic Child." European Annals of Allergy and Clinical Immunology, vol. 37, no. 7, 2005, pp. 257-61.
Kalach N, Soulaines P, Guerin S, et al. Time course of total and food specific IgE antibodies (Rast Fx5) in the developing allergic child. Eur Ann Allergy Clin Immunol. 2005;37(7):257-61.
Kalach, N., Soulaines, P., Guerin, S., de Boissieu, D., & Dupont, C. (2005). Time course of total and food specific IgE antibodies (Rast Fx5) in the developing allergic child. European Annals of Allergy and Clinical Immunology, 37(7), 257-61.
Kalach N, et al. Time Course of Total and Food Specific IgE Antibodies (Rast Fx5) in the Developing Allergic Child. Eur Ann Allergy Clin Immunol. 2005;37(7):257-61. PubMed PMID: 16285230.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Time course of total and food specific IgE antibodies (Rast Fx5) in the developing allergic child. AU - Kalach,Nicolas, AU - Soulaines,Pascale, AU - Guerin,Sylvie, AU - de Boissieu,Delphine, AU - Dupont,Christophe, PY - 2005/11/16/pubmed PY - 2005/12/15/medline PY - 2005/11/16/entrez SP - 257 EP - 61 JF - European annals of allergy and clinical immunology JO - Eur Ann Allergy Clin Immunol VL - 37 IS - 7 N2 - AIM: To analyze the evolution of total and food specific IgE (Rast Fx5) titers in the course of food allergy in children. PATIENTS & METHODS: 925 children, mean age 8.9 + 9.1 years (15 days-18 years), 455 girls and 470 boys, investigated for food allergy in year 1997, underwent serum samples assay for total IgE and of Rast Fx5, Cap System, Pharmacia & Upjohn Diagnostics AB, Uppsala, Sweden, a mix test detecting specific IgE to 6 major food allergens in children, cow's milk proteins (CMP), egg white, peanut, soy, wheat and fish and analyzed as a function of reference values by age. RESULTS: Total IgE titers increased significantly with age, r0.22, p0.0001. The percentage of children with a total IgE level above normal range first increased with age, from 10.3 % at 0-6 months, reaching 38.2 % at 1-2 years and peaking at 56.9% at 4-6 years, then leveled off, 48.1% at 8-12 years (ns vs 4-6 years) and 41.3% above 12 years (ns). Detectable Rast Fx5 increased in a parallel manner until age 4-6 years and then exhibited a progressive decrease from age 6-8 years, differing significantly from total IgE: 31.9% vs 52.9%, p0.01 (6-8 years), 32.2% vs 48.1%, p0.03 (8-12 years), 21.8% vs 41.3%, p0.05 (> 12 years). CONCLUSION: In these outpatient children investigated for food allergy, the increase with age of the percentage of high total IgE contrasted with the progressive decrease of Rast Fx5 from age 4-6 yr. This biological finding correlates timely with the clinical spontaneous decrease of food allergy in the developing child. SN - 1764-1489 UR - https://www.unboundmedicine.com/medline/citation/16285230/Time_course_of_total_and_food_specific_IgE_antibodies__Rast_Fx5__in_the_developing_allergic_child_ L2 - https://medlineplus.gov/foodallergy.html DB - PRIME DP - Unbound Medicine ER -