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Deposition method for preparing SERS-active gold nanoparticle substrates.
Anal Chem. 2005 Nov 15; 77(22):7462-71.AC

Abstract

Surface-enhanced Raman scattering or SERS, discovered some 20 years ago, has recently become a promising tool for routine biofluid assays in a clinical setting. Many attempts have been made to produce cheap and reproducible SERS-active substrates. In this study, we report on the fabrication of SERS-active substrates through the convective assembly of gold (Au) particles on electrostatically charged glass slides. We show that, by a proper control of the initial particle concentration in an evaporating Au suspension droplet, it is possible to obtain a closely packed colloidal film capable of generating SERS activity. Finally, AFM and SERS measurements of the resulting films reveal comparability in performance with previous silane-immobilized Au colloidal films. The minimum electromagnetic enhancement factor of our films is estimated to be about 2 x 10(4).

Authors+Show Affiliations

Kho KW
Division of Medical Sciences, National Cancer Centre, Singapore.
Shen ZX
No affiliation info available
Zeng HC
No affiliation info available
Soo KC
No affiliation info available
Olivo M
No affiliation info available

MeSH

ColloidsGentian VioletGoldMetal NanoparticlesMicroscopy, Atomic ForceMolecular StructureSpectrum Analysis, Raman

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16285701

Citation

Kho, Kiang Wei, et al. "Deposition Method for Preparing SERS-active Gold Nanoparticle Substrates." Analytical Chemistry, vol. 77, no. 22, 2005, pp. 7462-71.
Kho KW, Shen ZX, Zeng HC, et al. Deposition method for preparing SERS-active gold nanoparticle substrates. Anal Chem. 2005;77(22):7462-71.
Kho, K. W., Shen, Z. X., Zeng, H. C., Soo, K. C., & Olivo, M. (2005). Deposition method for preparing SERS-active gold nanoparticle substrates. Analytical Chemistry, 77(22), 7462-71.
Kho KW, et al. Deposition Method for Preparing SERS-active Gold Nanoparticle Substrates. Anal Chem. 2005 Nov 15;77(22):7462-71. PubMed PMID: 16285701.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Deposition method for preparing SERS-active gold nanoparticle substrates. AU - Kho,Kiang Wei, AU - Shen,Ze Xiang, AU - Zeng,Hua Chun, AU - Soo,Khee Chee, AU - Olivo,Malini, PY - 2005/11/16/pubmed PY - 2007/4/3/medline PY - 2005/11/16/entrez SP - 7462 EP - 71 JF - Analytical chemistry JO - Anal Chem VL - 77 IS - 22 N2 - Surface-enhanced Raman scattering or SERS, discovered some 20 years ago, has recently become a promising tool for routine biofluid assays in a clinical setting. Many attempts have been made to produce cheap and reproducible SERS-active substrates. In this study, we report on the fabrication of SERS-active substrates through the convective assembly of gold (Au) particles on electrostatically charged glass slides. We show that, by a proper control of the initial particle concentration in an evaporating Au suspension droplet, it is possible to obtain a closely packed colloidal film capable of generating SERS activity. Finally, AFM and SERS measurements of the resulting films reveal comparability in performance with previous silane-immobilized Au colloidal films. The minimum electromagnetic enhancement factor of our films is estimated to be about 2 x 10(4). SN - 0003-2700 UR - https://www.unboundmedicine.com/medline/citation/16285701/Deposition_method_for_preparing_SERS_active_gold_nanoparticle_substrates_ DB - PRIME DP - Unbound Medicine ER -