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Some effects of a topical collagen-based matrix on the microcirculation and wound healing in patients with chronic venous leg ulcers: preliminary observations.

Abstract

The microcirculation of the wound bed is a key parameter for improving granulation tissue formation and, hence, wound healing. The aim of this study was to determine whether a wound dressing comprising collagen/oxidized regenerated cellulose has effects over a short term on wound healing. Wounds were evaluated using a clinical wound score; pain associated with wounds was measured using a visual analogue scale. Wound microcirculation was evaluated using a technique based on noncontact remission spectroscopy. A prospective trial was performed in 40 patients with chronic venous leg ulcers (mean age 74 years; range, 43-93 years; 25 females and 15 males). Patients in group A were treated with PROMOGRAN Matrix (Johnson& Johnson, New Brunswick, NJ) combined with "good" ulcer care for 2 weeks. Control group B consisted of 10 patients who received only good ulcer care. The authors measured a favorable clinical response in 76.9% (group A) versus 66.7% (group B). The mean reduction of ulcer area was statistically significant in group A (P < .05). The wound score improved in group A from 2.28 +/- 1.24 (before treatment) increasing to 3.72 +/- 1.57 (after 1 week; P < .00023) and 4.92 +/- 1.68 (after 2 weeks; P < .000027). In group B, the score improved from 1.44 +/- 1.33 (before treatment) to 3.22 +/- 1.30 (after 1 week; P < .0077). The mean visual analogue pain score before treatment was 8.72 (group A) and 7.88 (group B) (ns, P > .05). After 1 week of treatment, the score dropped to 5.76 (group A) and 6.66 (group B). In the second week, group A patients had a mean pain score of 3.84 compared with the pain score before treatment (P < .05). After 1 week of treatment, in group A there was a decrease in remission spectroscopy, which is considered to reflect an improvement in microcirculation.

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  • Authors+Show Affiliations

    ,

    Department of Dermatology, Hospital Dresden-Friedrichstadt, Academic Teaching Hospital of the Technical University of Dresden, Germany. wollina-uw@khdf.de

    , , , ,

    Source

    MeSH

    Adult
    Aged
    Aged, 80 and over
    Bandages
    Cellulose, Oxidized
    Collagen
    Diagnostic Techniques and Procedures
    Equipment Design
    Female
    Humans
    Male
    Microcirculation
    Middle Aged
    Prospective Studies
    Varicose Ulcer
    Wound Healing

    Pub Type(s)

    Clinical Trial
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    16286373

    Citation

    Wollina, Uwe, et al. "Some Effects of a Topical Collagen-based Matrix On the Microcirculation and Wound Healing in Patients With Chronic Venous Leg Ulcers: Preliminary Observations." The International Journal of Lower Extremity Wounds, vol. 4, no. 4, 2005, pp. 214-24.
    Wollina U, Schmidt WD, Krönert C, et al. Some effects of a topical collagen-based matrix on the microcirculation and wound healing in patients with chronic venous leg ulcers: preliminary observations. Int J Low Extrem Wounds. 2005;4(4):214-24.
    Wollina, U., Schmidt, W. D., Krönert, C., Nelskamp, C., Scheibe, A., & Fassler, D. (2005). Some effects of a topical collagen-based matrix on the microcirculation and wound healing in patients with chronic venous leg ulcers: preliminary observations. The International Journal of Lower Extremity Wounds, 4(4), pp. 214-24.
    Wollina U, et al. Some Effects of a Topical Collagen-based Matrix On the Microcirculation and Wound Healing in Patients With Chronic Venous Leg Ulcers: Preliminary Observations. Int J Low Extrem Wounds. 2005;4(4):214-24. PubMed PMID: 16286373.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Some effects of a topical collagen-based matrix on the microcirculation and wound healing in patients with chronic venous leg ulcers: preliminary observations. AU - Wollina,Uwe, AU - Schmidt,Wolf-Dieter, AU - Krönert,Claudia, AU - Nelskamp,Cornelia, AU - Scheibe,Armin, AU - Fassler,Dieter, PY - 2005/11/16/pubmed PY - 2006/5/17/medline PY - 2005/11/16/entrez SP - 214 EP - 24 JF - The international journal of lower extremity wounds JO - Int J Low Extrem Wounds VL - 4 IS - 4 N2 - The microcirculation of the wound bed is a key parameter for improving granulation tissue formation and, hence, wound healing. The aim of this study was to determine whether a wound dressing comprising collagen/oxidized regenerated cellulose has effects over a short term on wound healing. Wounds were evaluated using a clinical wound score; pain associated with wounds was measured using a visual analogue scale. Wound microcirculation was evaluated using a technique based on noncontact remission spectroscopy. A prospective trial was performed in 40 patients with chronic venous leg ulcers (mean age 74 years; range, 43-93 years; 25 females and 15 males). Patients in group A were treated with PROMOGRAN Matrix (Johnson& Johnson, New Brunswick, NJ) combined with "good" ulcer care for 2 weeks. Control group B consisted of 10 patients who received only good ulcer care. The authors measured a favorable clinical response in 76.9% (group A) versus 66.7% (group B). The mean reduction of ulcer area was statistically significant in group A (P < .05). The wound score improved in group A from 2.28 +/- 1.24 (before treatment) increasing to 3.72 +/- 1.57 (after 1 week; P < .00023) and 4.92 +/- 1.68 (after 2 weeks; P < .000027). In group B, the score improved from 1.44 +/- 1.33 (before treatment) to 3.22 +/- 1.30 (after 1 week; P < .0077). The mean visual analogue pain score before treatment was 8.72 (group A) and 7.88 (group B) (ns, P > .05). After 1 week of treatment, the score dropped to 5.76 (group A) and 6.66 (group B). In the second week, group A patients had a mean pain score of 3.84 compared with the pain score before treatment (P < .05). After 1 week of treatment, in group A there was a decrease in remission spectroscopy, which is considered to reflect an improvement in microcirculation. SN - 1534-7346 UR - https://www.unboundmedicine.com/medline/citation/16286373/Some_effects_of_a_topical_collagen_based_matrix_on_the_microcirculation_and_wound_healing_in_patients_with_chronic_venous_leg_ulcers:_preliminary_observations_ L2 - http://journals.sagepub.com/doi/full/10.1177/1534734605283001?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -