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Pancreatic juice cytology in the diagnosis of intraductal papillary mucinous neoplasm of the pancreas: significance of sampling by peroral pancreatoscopy.
Cancer. 2005 Dec 15; 104(12):2830-6.C

Abstract

BACKGROUND

The examination of pancreatic juice cytology could hypothetically contribute to the establishment of a definite diagnosis of malignant intraductal papillary mucinous neoplasm of the pancreas (IPMN), but to the authors' knowledge, its significance has not been confirmed to date. The current study was conducted to assess the diagnostic value of pancreatic juice cytology in IPMN and to examine the usefulness of peroral pancreatoscopy (POPS) in sampling pancreatic juice.

METHODS

The study subjects were comprised of 103 patients with IPMN who underwent surgical resection of pancreatic tumors (adenoma in 29 patients, borderline in 17 patients, carcinoma in situ in 25 patients, and invasive carcinoma in 32 patients). Pancreatic juice was collected with a catheter in 71 patients and by POPS in 32 patients. Patients with pancreatic carcinoma (n = 81) and chronic pancreatitis (n = 76) also were investigated.

RESULTS

The cytologic diagnosis was found to be of nondiagnostic value in only one patient with an IPMN, whereas it was of no diagnostic value in 14 of the patients with pancreatic carcinoma (17.3%), a difference that was statically significant (P < 0.001). The location of the IPMN (either in the pancreas or the pancreatic ducts) was not found to significantly affect the diagnostic value of the test. The sensitivity for IPMN was 62.2% when pancreatic juice was collected by POPS, and was 38.2% when it was collected using a catheter. In the case of pancreatic carcinoma, the sensitivity of pancreatic juice cytology was found to be 25.4%, which was significantly lower than that for IPMN when the pancreatic juice was collected by POPS (P < 0.001).

CONCLUSIONS

Pancreatic juice cytology was found to have better diagnostic value in the patients with IPMNs compared with those with pancreatic carcinoma. POPS was found to be useful for the collection of pancreatic juice.

Authors+Show Affiliations

Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Japan. yama.take@faculty.chiba-u.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16287152

Citation

Yamaguchi, Taketo, et al. "Pancreatic Juice Cytology in the Diagnosis of Intraductal Papillary Mucinous Neoplasm of the Pancreas: Significance of Sampling By Peroral Pancreatoscopy." Cancer, vol. 104, no. 12, 2005, pp. 2830-6.
Yamaguchi T, Shirai Y, Ishihara T, et al. Pancreatic juice cytology in the diagnosis of intraductal papillary mucinous neoplasm of the pancreas: significance of sampling by peroral pancreatoscopy. Cancer. 2005;104(12):2830-6.
Yamaguchi, T., Shirai, Y., Ishihara, T., Sudo, K., Nakagawa, A., Ito, H., Miyazaki, M., Nomura, F., & Saisho, H. (2005). Pancreatic juice cytology in the diagnosis of intraductal papillary mucinous neoplasm of the pancreas: significance of sampling by peroral pancreatoscopy. Cancer, 104(12), 2830-6.
Yamaguchi T, et al. Pancreatic Juice Cytology in the Diagnosis of Intraductal Papillary Mucinous Neoplasm of the Pancreas: Significance of Sampling By Peroral Pancreatoscopy. Cancer. 2005 Dec 15;104(12):2830-6. PubMed PMID: 16287152.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pancreatic juice cytology in the diagnosis of intraductal papillary mucinous neoplasm of the pancreas: significance of sampling by peroral pancreatoscopy. AU - Yamaguchi,Taketo, AU - Shirai,Yoshihiko, AU - Ishihara,Takeshi, AU - Sudo,Kentarou, AU - Nakagawa,Akihiko, AU - Ito,Hiroshi, AU - Miyazaki,Masaru, AU - Nomura,Fumio, AU - Saisho,Hiromitsu, PY - 2005/11/16/pubmed PY - 2006/1/20/medline PY - 2005/11/16/entrez SP - 2830 EP - 6 JF - Cancer JO - Cancer VL - 104 IS - 12 N2 - BACKGROUND: The examination of pancreatic juice cytology could hypothetically contribute to the establishment of a definite diagnosis of malignant intraductal papillary mucinous neoplasm of the pancreas (IPMN), but to the authors' knowledge, its significance has not been confirmed to date. The current study was conducted to assess the diagnostic value of pancreatic juice cytology in IPMN and to examine the usefulness of peroral pancreatoscopy (POPS) in sampling pancreatic juice. METHODS: The study subjects were comprised of 103 patients with IPMN who underwent surgical resection of pancreatic tumors (adenoma in 29 patients, borderline in 17 patients, carcinoma in situ in 25 patients, and invasive carcinoma in 32 patients). Pancreatic juice was collected with a catheter in 71 patients and by POPS in 32 patients. Patients with pancreatic carcinoma (n = 81) and chronic pancreatitis (n = 76) also were investigated. RESULTS: The cytologic diagnosis was found to be of nondiagnostic value in only one patient with an IPMN, whereas it was of no diagnostic value in 14 of the patients with pancreatic carcinoma (17.3%), a difference that was statically significant (P < 0.001). The location of the IPMN (either in the pancreas or the pancreatic ducts) was not found to significantly affect the diagnostic value of the test. The sensitivity for IPMN was 62.2% when pancreatic juice was collected by POPS, and was 38.2% when it was collected using a catheter. In the case of pancreatic carcinoma, the sensitivity of pancreatic juice cytology was found to be 25.4%, which was significantly lower than that for IPMN when the pancreatic juice was collected by POPS (P < 0.001). CONCLUSIONS: Pancreatic juice cytology was found to have better diagnostic value in the patients with IPMNs compared with those with pancreatic carcinoma. POPS was found to be useful for the collection of pancreatic juice. SN - 0008-543X UR - https://www.unboundmedicine.com/medline/citation/16287152/Pancreatic_juice_cytology_in_the_diagnosis_of_intraductal_papillary_mucinous_neoplasm_of_the_pancreas:_significance_of_sampling_by_peroral_pancreatoscopy_ L2 - https://doi.org/10.1002/cncr.21565 DB - PRIME DP - Unbound Medicine ER -