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Clinical observations of the effect of antidiuretic hormone on nocturia in elderly men.
BJU Int. 2005 Dec; 96(9):1310-3.BI

Abstract

OBJECTIVE

To evaluate the effect of desmopressin on nocturia, based on patients' subjective scoring of nocturia, as desmopressin is widely used to treat nocturnal enuresis and nocturnal polyuria.

PATIENTS AND METHODS

We investigated a specific subgroup of 28 men with benign prostate obstruction and nocturia who were treated with desmopressin. Patients with nocturnal polyuria were excluded. All the patients were refractory to treatment with antimuscarinics or anticholinergics, e.g. oxybutynin, tolterodine, and propantheline bromide. We assessed the effect of desmopressin using a quantitative nocturia score and analysed its synergistic effect with alpha-blockers.

RESULTS

The mean frequency of nocturia was 6.1 before desmopressin and most (86%) patients had an improvement in nocturia within 1-12 weeks of treatment with desmopressin. There was a 43% reduction in nocturia after using desmopressin (P < 0.001). The correlation coefficient between the number of nocturnal voids and the reduction in nocturia after treatment with desmopressin was 0.756, indicating that the more severe the nocturia, the more effective was desmopressin.

CONCLUSIONS

Desmopressin is effective for refractory nocturia in elderly men with no nocturnal polyuria, and has limited side-effects.

Authors+Show Affiliations

Division of Urology, Department of Surgery, Chang Gung Memorial Hospital, Chia-Yi, Taiwan, ROC.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16287451

Citation

Ho, Dong-Ru, et al. "Clinical Observations of the Effect of Antidiuretic Hormone On Nocturia in Elderly Men." BJU International, vol. 96, no. 9, 2005, pp. 1310-3.
Ho DR, Lin WY, Wu CF, et al. Clinical observations of the effect of antidiuretic hormone on nocturia in elderly men. BJU Int. 2005;96(9):1310-3.
Ho, D. R., Lin, W. Y., Wu, C. F., Shee, J. J., Huang, Y. C., & Chen, C. S. (2005). Clinical observations of the effect of antidiuretic hormone on nocturia in elderly men. BJU International, 96(9), 1310-3.
Ho DR, et al. Clinical Observations of the Effect of Antidiuretic Hormone On Nocturia in Elderly Men. BJU Int. 2005;96(9):1310-3. PubMed PMID: 16287451.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical observations of the effect of antidiuretic hormone on nocturia in elderly men. AU - Ho,Dong-Ru, AU - Lin,Wei-Yu, AU - Wu,Ching-Fang, AU - Shee,Jia-Jen, AU - Huang,Yun-Ching, AU - Chen,Chih-Shou, PY - 2005/11/17/pubmed PY - 2005/12/24/medline PY - 2005/11/17/entrez SP - 1310 EP - 3 JF - BJU international JO - BJU Int VL - 96 IS - 9 N2 - OBJECTIVE: To evaluate the effect of desmopressin on nocturia, based on patients' subjective scoring of nocturia, as desmopressin is widely used to treat nocturnal enuresis and nocturnal polyuria. PATIENTS AND METHODS: We investigated a specific subgroup of 28 men with benign prostate obstruction and nocturia who were treated with desmopressin. Patients with nocturnal polyuria were excluded. All the patients were refractory to treatment with antimuscarinics or anticholinergics, e.g. oxybutynin, tolterodine, and propantheline bromide. We assessed the effect of desmopressin using a quantitative nocturia score and analysed its synergistic effect with alpha-blockers. RESULTS: The mean frequency of nocturia was 6.1 before desmopressin and most (86%) patients had an improvement in nocturia within 1-12 weeks of treatment with desmopressin. There was a 43% reduction in nocturia after using desmopressin (P < 0.001). The correlation coefficient between the number of nocturnal voids and the reduction in nocturia after treatment with desmopressin was 0.756, indicating that the more severe the nocturia, the more effective was desmopressin. CONCLUSIONS: Desmopressin is effective for refractory nocturia in elderly men with no nocturnal polyuria, and has limited side-effects. SN - 1464-4096 UR - https://www.unboundmedicine.com/medline/citation/16287451/Clinical_observations_of_the_effect_of_antidiuretic_hormone_on_nocturia_in_elderly_men_ L2 - https://doi.org/10.1111/j.1464-410X.2005.05829.x DB - PRIME DP - Unbound Medicine ER -