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Overall obesity, abdominal adiposity, diabetes and cigarette smoking in relation to the risk of pancreatic cancer in two Swedish population-based cohorts.
Br J Cancer 2005; 93(11):1310-5BJ

Abstract

We examined the associations of body mass index (BMI), waist circumference, a history of diabetes, and cigarette smoking with risk of pancreatic cancer among 37,147 women and 45,906 men followed up during 560,666 person-years in the Swedish Mammography Cohort and the Cohort of Swedish Men; 136 incident cases of pancreatic cancer were diagnosed. The multivariate rate ratio (RR) of pancreatic cancer for obese women and men (BMI > or =30 kg/m(2)) was 1.81 (95% CI: 1.04-3.15) compared to those with a BMI of 20-25 kg/m(2). For a difference of 20 cm (about two standard deviations) in waist circumference, the multivariate RRs were 1.32 (95% CI: 0.73-2.37) among women and 1.74 (95% CI: 1.00-3.01) among men. Pancreatic cancer risk was associated with history of diabetes (multivariate RR: 1.88; 95% CI: 1.09-3.26) and cigarette smoking (multivariate RR for current compared with never smokers: 3.06; 95% CI: 1.99-4.72). Current smokers of > or =40 pack-years had a five-fold elevated risk compared with never smokers. Risk among past smokers approached the RR for never smokers within 5-10 years following smoking cessation. Findings from this prospective study support positive relationships of overall obesity, abdominal adiposity, diabetes and smoking with risk of pancreatic cancer.

Authors+Show Affiliations

Division of Nutritional Epidemiology, The National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. susanna.larsson@ki.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16288300

Citation

Larsson, S C., et al. "Overall Obesity, Abdominal Adiposity, Diabetes and Cigarette Smoking in Relation to the Risk of Pancreatic Cancer in Two Swedish Population-based Cohorts." British Journal of Cancer, vol. 93, no. 11, 2005, pp. 1310-5.
Larsson SC, Permert J, Håkansson N, et al. Overall obesity, abdominal adiposity, diabetes and cigarette smoking in relation to the risk of pancreatic cancer in two Swedish population-based cohorts. Br J Cancer. 2005;93(11):1310-5.
Larsson, S. C., Permert, J., Håkansson, N., Näslund, I., Bergkvist, L., & Wolk, A. (2005). Overall obesity, abdominal adiposity, diabetes and cigarette smoking in relation to the risk of pancreatic cancer in two Swedish population-based cohorts. British Journal of Cancer, 93(11), pp. 1310-5.
Larsson SC, et al. Overall Obesity, Abdominal Adiposity, Diabetes and Cigarette Smoking in Relation to the Risk of Pancreatic Cancer in Two Swedish Population-based Cohorts. Br J Cancer. 2005 Nov 28;93(11):1310-5. PubMed PMID: 16288300.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Overall obesity, abdominal adiposity, diabetes and cigarette smoking in relation to the risk of pancreatic cancer in two Swedish population-based cohorts. AU - Larsson,S C, AU - Permert,J, AU - Håkansson,N, AU - Näslund,I, AU - Bergkvist,L, AU - Wolk,A, PY - 2005/11/17/pubmed PY - 2006/1/7/medline PY - 2005/11/17/entrez SP - 1310 EP - 5 JF - British journal of cancer JO - Br. J. Cancer VL - 93 IS - 11 N2 - We examined the associations of body mass index (BMI), waist circumference, a history of diabetes, and cigarette smoking with risk of pancreatic cancer among 37,147 women and 45,906 men followed up during 560,666 person-years in the Swedish Mammography Cohort and the Cohort of Swedish Men; 136 incident cases of pancreatic cancer were diagnosed. The multivariate rate ratio (RR) of pancreatic cancer for obese women and men (BMI > or =30 kg/m(2)) was 1.81 (95% CI: 1.04-3.15) compared to those with a BMI of 20-25 kg/m(2). For a difference of 20 cm (about two standard deviations) in waist circumference, the multivariate RRs were 1.32 (95% CI: 0.73-2.37) among women and 1.74 (95% CI: 1.00-3.01) among men. Pancreatic cancer risk was associated with history of diabetes (multivariate RR: 1.88; 95% CI: 1.09-3.26) and cigarette smoking (multivariate RR for current compared with never smokers: 3.06; 95% CI: 1.99-4.72). Current smokers of > or =40 pack-years had a five-fold elevated risk compared with never smokers. Risk among past smokers approached the RR for never smokers within 5-10 years following smoking cessation. Findings from this prospective study support positive relationships of overall obesity, abdominal adiposity, diabetes and smoking with risk of pancreatic cancer. SN - 0007-0920 UR - https://www.unboundmedicine.com/medline/citation/16288300/Overall_obesity_abdominal_adiposity_diabetes_and_cigarette_smoking_in_relation_to_the_risk_of_pancreatic_cancer_in_two_Swedish_population_based_cohorts_ L2 - http://dx.doi.org/10.1038/sj.bjc.6602868 DB - PRIME DP - Unbound Medicine ER -