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CD4+ T cell recovery beyond the first year of complete suppression of viral replication during highly active antiretroviral therapy is not influenced by CD8+ T cell activation.
J Infect Dis. 2005 Dec 15; 192(12):2142-6.JI

Abstract

CD38 expression on CD8(+) T cells was longitudinally assessed in 31 human immunodeficiency virus (HIV)-infected persons with undetectable plasma viremia who had undergone highly active antiretroviral therapy (HAART) for 12 months and were followed for a mean of 30 months thereafter. Overall, CD4(+)T cell counts increased during follow-up, whereas CD38 expression remained stable. However, a subset of patients showed declines in CD38 expression, and, conversely, another subset showed increases in CD38 expression. No association could be found between long-term gains in CD4(+) T cells and evolution of CD38 expression. Thus, activation of CD8(+) T cells does not seem to be associated with the extent of CD4(+) T cell recovery beyond the first year of successful HAART.

Authors+Show Affiliations

Service of Infectious Diseases, Hospital Carlos III, Madrid, Spain. jbenito1@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16288380

Citation

Benito, Jose M., et al. "CD4+ T Cell Recovery Beyond the First Year of Complete Suppression of Viral Replication During Highly Active Antiretroviral Therapy Is Not Influenced By CD8+ T Cell Activation." The Journal of Infectious Diseases, vol. 192, no. 12, 2005, pp. 2142-6.
Benito JM, Lopez M, Lozano S, et al. CD4+ T cell recovery beyond the first year of complete suppression of viral replication during highly active antiretroviral therapy is not influenced by CD8+ T cell activation. J Infect Dis. 2005;192(12):2142-6.
Benito, J. M., Lopez, M., Lozano, S., Ballesteros, C., Capa, L., Martinez, P., Gonzalez-Lahoz, J., & Soriano, V. (2005). CD4+ T cell recovery beyond the first year of complete suppression of viral replication during highly active antiretroviral therapy is not influenced by CD8+ T cell activation. The Journal of Infectious Diseases, 192(12), 2142-6.
Benito JM, et al. CD4+ T Cell Recovery Beyond the First Year of Complete Suppression of Viral Replication During Highly Active Antiretroviral Therapy Is Not Influenced By CD8+ T Cell Activation. J Infect Dis. 2005 Dec 15;192(12):2142-6. PubMed PMID: 16288380.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - CD4+ T cell recovery beyond the first year of complete suppression of viral replication during highly active antiretroviral therapy is not influenced by CD8+ T cell activation. AU - Benito,Jose M, AU - Lopez,Mariola, AU - Lozano,Sara, AU - Ballesteros,Celia, AU - Capa,Laura, AU - Martinez,Pilar, AU - Gonzalez-Lahoz,Juan, AU - Soriano,Vincent, PY - 2005/04/20/received PY - 2005/06/29/accepted PY - 2005/11/17/pubmed PY - 2006/2/4/medline PY - 2005/11/17/entrez SP - 2142 EP - 6 JF - The Journal of infectious diseases JO - J Infect Dis VL - 192 IS - 12 N2 - CD38 expression on CD8(+) T cells was longitudinally assessed in 31 human immunodeficiency virus (HIV)-infected persons with undetectable plasma viremia who had undergone highly active antiretroviral therapy (HAART) for 12 months and were followed for a mean of 30 months thereafter. Overall, CD4(+)T cell counts increased during follow-up, whereas CD38 expression remained stable. However, a subset of patients showed declines in CD38 expression, and, conversely, another subset showed increases in CD38 expression. No association could be found between long-term gains in CD4(+) T cells and evolution of CD38 expression. Thus, activation of CD8(+) T cells does not seem to be associated with the extent of CD4(+) T cell recovery beyond the first year of successful HAART. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/16288380/CD4+_T_cell_recovery_beyond_the_first_year_of_complete_suppression_of_viral_replication_during_highly_active_antiretroviral_therapy_is_not_influenced_by_CD8+_T_cell_activation_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1086/498168 DB - PRIME DP - Unbound Medicine ER -