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Intra-operative STN DBS attenuates the prominent beta rhythm in the STN in Parkinson's disease.
Exp Neurol. 2006 Jan; 197(1):244-51.EN

Abstract

Power spectra from local field potentials (LFPs) recorded post-operatively from the deep brain stimulation (DBS) macroelectrode show prominence of the beta rhythm (11-30 Hz) in untreated Parkinson's disease (PD). Dopaminergic medication and movement attenuate this beta band in PD. In this pilot study of six sides in four patients, we recorded LFPs from the DBS electrode in untreated PD patients in the operating room. In all cases, there was a peak in the time-frequency spectrogram in the beta frequency range when the patients were at rest, which was associated with attenuation in the same range with movement. The actual frequency range and the strength of the beta peak varied among cases. In two patients, intra-operative constraints permitted recording of LFPs at rest, before and immediately after subthalamic nucleus (STN) DBS. In both patients we documented that STN DBS caused a significant attenuation in power in the beta band at rest that persisted for 15-25 s after DBS had been turned off (P < 0.01). From one case, our data suggest that the beta rhythm attenuation was most prominent within the STN itself. This study shows for the first time that STN DBS attenuates the power in the prominent beta band recorded in the STN of patients with PD. These pilot findings raise the interesting possibility of using this biomarker for closed loop DBS or neuromodulation.

Authors+Show Affiliations

NeuroPace Inc., Mountain View, California, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16289053

Citation

Wingeier, Brett, et al. "Intra-operative STN DBS Attenuates the Prominent Beta Rhythm in the STN in Parkinson's Disease." Experimental Neurology, vol. 197, no. 1, 2006, pp. 244-51.
Wingeier B, Tcheng T, Koop MM, et al. Intra-operative STN DBS attenuates the prominent beta rhythm in the STN in Parkinson's disease. Exp Neurol. 2006;197(1):244-51.
Wingeier, B., Tcheng, T., Koop, M. M., Hill, B. C., Heit, G., & Bronte-Stewart, H. M. (2006). Intra-operative STN DBS attenuates the prominent beta rhythm in the STN in Parkinson's disease. Experimental Neurology, 197(1), 244-51.
Wingeier B, et al. Intra-operative STN DBS Attenuates the Prominent Beta Rhythm in the STN in Parkinson's Disease. Exp Neurol. 2006;197(1):244-51. PubMed PMID: 16289053.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intra-operative STN DBS attenuates the prominent beta rhythm in the STN in Parkinson's disease. AU - Wingeier,Brett, AU - Tcheng,Tom, AU - Koop,Mandy Miller, AU - Hill,Bruce C, AU - Heit,Gary, AU - Bronte-Stewart,Helen M, Y1 - 2005/11/10/ PY - 2005/07/06/received PY - 2005/09/12/revised PY - 2005/09/16/accepted PY - 2005/11/18/pubmed PY - 2006/2/9/medline PY - 2005/11/18/entrez SP - 244 EP - 51 JF - Experimental neurology JO - Exp Neurol VL - 197 IS - 1 N2 - Power spectra from local field potentials (LFPs) recorded post-operatively from the deep brain stimulation (DBS) macroelectrode show prominence of the beta rhythm (11-30 Hz) in untreated Parkinson's disease (PD). Dopaminergic medication and movement attenuate this beta band in PD. In this pilot study of six sides in four patients, we recorded LFPs from the DBS electrode in untreated PD patients in the operating room. In all cases, there was a peak in the time-frequency spectrogram in the beta frequency range when the patients were at rest, which was associated with attenuation in the same range with movement. The actual frequency range and the strength of the beta peak varied among cases. In two patients, intra-operative constraints permitted recording of LFPs at rest, before and immediately after subthalamic nucleus (STN) DBS. In both patients we documented that STN DBS caused a significant attenuation in power in the beta band at rest that persisted for 15-25 s after DBS had been turned off (P < 0.01). From one case, our data suggest that the beta rhythm attenuation was most prominent within the STN itself. This study shows for the first time that STN DBS attenuates the power in the prominent beta band recorded in the STN of patients with PD. These pilot findings raise the interesting possibility of using this biomarker for closed loop DBS or neuromodulation. SN - 0014-4886 UR - https://www.unboundmedicine.com/medline/citation/16289053/Intra_operative_STN_DBS_attenuates_the_prominent_beta_rhythm_in_the_STN_in_Parkinson's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-4886(05)00350-X DB - PRIME DP - Unbound Medicine ER -