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Action of Hygrophila auriculata against streptozotocin-induced oxidative stress.
J Ethnopharmacol. 2006 Apr 06; 104(3):356-61.JE

Abstract

Hygrophila auriculata (K. Schum.) Heine (Family: Acanthaceae) is a wild herb widely used in 'Ayurveda' as 'Rasayana' drug for treatment of various disorders. Treatment of diabetic rats with aerial parts of Hygrophila auriculata extract (HAEt, 100 and 250 mg/kg body weight) for 3 weeks showed significant reduction in blood glucose, thiobarbituric acid reactive substances (TBARS) and hydroperoxide in both liver and kidney. The treatment with HAEt significantly increased the glutathione (GSH), glutathione peroxidase (GPx), glutathione S-transferase (GST) and catalase (CAT) in the drug-treated group, which is comparable to the control group. HAEt and glibenclamide-treated rats also showed decreased lipid peroxidation that is associated with increased activity of superoxide dismutase (SOD) and catalase. The ability of HAEt on tissue lipid peroxidation and antioxidant status in diabetic animals has not been studied before. The result of this study thus shows that HAEt possesses significant antidiabetic activity along with potent antioxidant potential in diabetic conditions.

Authors+Show Affiliations

Pharmacognosy and Ethnopharmacology Division, National Botanical Research Institute, Lucknow 226 001, Uttar Pradesh, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16289604

Citation

Vijayakumar, M, et al. "Action of Hygrophila Auriculata Against Streptozotocin-induced Oxidative Stress." Journal of Ethnopharmacology, vol. 104, no. 3, 2006, pp. 356-61.
Vijayakumar M, Govindarajan R, Rao GM, et al. Action of Hygrophila auriculata against streptozotocin-induced oxidative stress. J Ethnopharmacol. 2006;104(3):356-61.
Vijayakumar, M., Govindarajan, R., Rao, G. M., Rao, C. h. V., Shirwaikar, A., Mehrotra, S., & Pushpangadan, P. (2006). Action of Hygrophila auriculata against streptozotocin-induced oxidative stress. Journal of Ethnopharmacology, 104(3), 356-61.
Vijayakumar M, et al. Action of Hygrophila Auriculata Against Streptozotocin-induced Oxidative Stress. J Ethnopharmacol. 2006 Apr 6;104(3):356-61. PubMed PMID: 16289604.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Action of Hygrophila auriculata against streptozotocin-induced oxidative stress. AU - Vijayakumar,M, AU - Govindarajan,R, AU - Rao,G M M, AU - Rao,Ch V, AU - Shirwaikar,A, AU - Mehrotra,S, AU - Pushpangadan,P, Y1 - 2005/11/09/ PY - 2004/11/01/received PY - 2005/08/23/revised PY - 2005/09/24/accepted PY - 2005/11/18/pubmed PY - 2006/9/16/medline PY - 2005/11/18/entrez SP - 356 EP - 61 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 104 IS - 3 N2 - Hygrophila auriculata (K. Schum.) Heine (Family: Acanthaceae) is a wild herb widely used in 'Ayurveda' as 'Rasayana' drug for treatment of various disorders. Treatment of diabetic rats with aerial parts of Hygrophila auriculata extract (HAEt, 100 and 250 mg/kg body weight) for 3 weeks showed significant reduction in blood glucose, thiobarbituric acid reactive substances (TBARS) and hydroperoxide in both liver and kidney. The treatment with HAEt significantly increased the glutathione (GSH), glutathione peroxidase (GPx), glutathione S-transferase (GST) and catalase (CAT) in the drug-treated group, which is comparable to the control group. HAEt and glibenclamide-treated rats also showed decreased lipid peroxidation that is associated with increased activity of superoxide dismutase (SOD) and catalase. The ability of HAEt on tissue lipid peroxidation and antioxidant status in diabetic animals has not been studied before. The result of this study thus shows that HAEt possesses significant antidiabetic activity along with potent antioxidant potential in diabetic conditions. SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/16289604/Action_of_Hygrophila_auriculata_against_streptozotocin_induced_oxidative_stress_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(05)00660-4 DB - PRIME DP - Unbound Medicine ER -