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Evaluation of the photostability of different UV filter combinations in a sunscreen.
Int J Pharm. 2006 Jan 13; 307(2):123-8.IJ

Abstract

Development of photostable sunscreens is extremely important to preserve the UV protective capacity and to prevent the reactive intermediates of photounstable filter substances behaving as photo-oxidants when coming into direct contact with the skin. Thus, the objective of this study was to evaluate the photostability of four different UV filter combinations in a sunscreen by using HPLC analysis and spectrophotometry. The formulations that were investigated included four different UV filter combinations often used in SPF 15 sunscreens. The UV filter combinations were: octyl methoxycinnamate (OMC), benzophenone-3 (BP-3) and octyl salicylate (OS) (formulation 1); OMC, avobenzone (AVB) and 4-methylbenzilidene camphor (MBC) (formulation 2); OMC, BP-3 and octocrylene (OC) (formulation 3); OMC, AVB and OC (formulation 4). In the photostability studies, 40 mg of each formulation were spread onto a glass plate and left to dry before exposure to different UVA/UVB irradiation. Exposed samples were then immersed in isopropanol and the dried film dissolved ultrasonically. The filter components in the resulting solution were quantified by HPLC analysis with detection at 325 nm and by spectrophotometry. In this study, the four UV filter combinations showed different photostability profiles and the best one was formulation 3 (OMC, BP-3 and OC), followed by formulations 4, 1 and 2. In addition, OC improved the photostability of OMC, AVB and BP-3.

Authors+Show Affiliations

Universidade de São Paulo, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Bairro Monte Alegre, Ribeirão Preto, SP, Brazil.No affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16289662

Citation

Gaspar, L R., and P M B G. Maia Campos. "Evaluation of the Photostability of Different UV Filter Combinations in a Sunscreen." International Journal of Pharmaceutics, vol. 307, no. 2, 2006, pp. 123-8.
Gaspar LR, Maia Campos PM. Evaluation of the photostability of different UV filter combinations in a sunscreen. Int J Pharm. 2006;307(2):123-8.
Gaspar, L. R., & Maia Campos, P. M. (2006). Evaluation of the photostability of different UV filter combinations in a sunscreen. International Journal of Pharmaceutics, 307(2), 123-8.
Gaspar LR, Maia Campos PM. Evaluation of the Photostability of Different UV Filter Combinations in a Sunscreen. Int J Pharm. 2006 Jan 13;307(2):123-8. PubMed PMID: 16289662.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of the photostability of different UV filter combinations in a sunscreen. AU - Gaspar,L R, AU - Maia Campos,P M B G, Y1 - 2005/11/11/ PY - 2005/03/28/received PY - 2005/08/23/revised PY - 2005/08/23/accepted PY - 2005/11/18/pubmed PY - 2006/3/17/medline PY - 2005/11/18/entrez SP - 123 EP - 8 JF - International journal of pharmaceutics JO - Int J Pharm VL - 307 IS - 2 N2 - Development of photostable sunscreens is extremely important to preserve the UV protective capacity and to prevent the reactive intermediates of photounstable filter substances behaving as photo-oxidants when coming into direct contact with the skin. Thus, the objective of this study was to evaluate the photostability of four different UV filter combinations in a sunscreen by using HPLC analysis and spectrophotometry. The formulations that were investigated included four different UV filter combinations often used in SPF 15 sunscreens. The UV filter combinations were: octyl methoxycinnamate (OMC), benzophenone-3 (BP-3) and octyl salicylate (OS) (formulation 1); OMC, avobenzone (AVB) and 4-methylbenzilidene camphor (MBC) (formulation 2); OMC, BP-3 and octocrylene (OC) (formulation 3); OMC, AVB and OC (formulation 4). In the photostability studies, 40 mg of each formulation were spread onto a glass plate and left to dry before exposure to different UVA/UVB irradiation. Exposed samples were then immersed in isopropanol and the dried film dissolved ultrasonically. The filter components in the resulting solution were quantified by HPLC analysis with detection at 325 nm and by spectrophotometry. In this study, the four UV filter combinations showed different photostability profiles and the best one was formulation 3 (OMC, BP-3 and OC), followed by formulations 4, 1 and 2. In addition, OC improved the photostability of OMC, AVB and BP-3. SN - 0378-5173 UR - https://www.unboundmedicine.com/medline/citation/16289662/Evaluation_of_the_photostability_of_different_UV_filter_combinations_in_a_sunscreen_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5173(05)00649-6 DB - PRIME DP - Unbound Medicine ER -