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Attentional load of the primary task influences the frontal but not the temporal generators of mismatch negativity.
Brain Res Cogn Brain Res. 2005 Dec; 25(3):891-9.BR

Abstract

According to the model hypothesized by Näätänen and Michie, the generation of the mismatch negativity (MMN) requires a mismatch detection, taking place in temporal areas, followed by the activation of frontal generators, underlying attention switching toward the deviant stimulus. We aimed at verifying whether the activation of temporal and frontal regions is dependent on the amount of attentional resources allocable toward the deviant stimulus. We recorded event-related potentials (ERPs) in nine healthy subjects while reading and during a demanding visual task (Multiple Features Target Cancellation, MFTC). Raw data were further evaluated by Brain Electrical Source Analysis (BESA). During the Reading condition, distraction toward the unattended auditory stimuli was reflected by the enhancement of the N1 response to frequent stimuli and by the elicitation of a P3a response to deviant ones. The MMN distribution was explained by bilateral temporal dipoles. During the MFTC condition, no P3a was detected, while source analysis showed the activation of a right frontal generator. Temporal dipoles showed no change between the two conditions: we thus conclude that the earlier mismatch detection is independent on the attentional load. By contrast, the activation of a right frontal subcomponent occurred only during the high-load task, independently on any actual attention shift reflected by the P3a component. We thus discuss the hypothesis whether the right frontal MMN generator, rather than subserving a simple attention switching toward the deviant stimulus, plays a role in modulating the auditory change detection system ("contrast enhancement" model).

Authors+Show Affiliations

Department of Neurosciences, Catholic University, Policlinico A. Gemelli, L.go A. Gemelli 8, 00168 Rome, Italy. drestuccia@rm.unicatt.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

16289727

Citation

Restuccia, Domenico, et al. "Attentional Load of the Primary Task Influences the Frontal but Not the Temporal Generators of Mismatch Negativity." Brain Research. Cognitive Brain Research, vol. 25, no. 3, 2005, pp. 891-9.
Restuccia D, Della Marca G, Marra C, et al. Attentional load of the primary task influences the frontal but not the temporal generators of mismatch negativity. Brain Res Cogn Brain Res. 2005;25(3):891-9.
Restuccia, D., Della Marca, G., Marra, C., Rubino, M., & Valeriani, M. (2005). Attentional load of the primary task influences the frontal but not the temporal generators of mismatch negativity. Brain Research. Cognitive Brain Research, 25(3), 891-9.
Restuccia D, et al. Attentional Load of the Primary Task Influences the Frontal but Not the Temporal Generators of Mismatch Negativity. Brain Res Cogn Brain Res. 2005;25(3):891-9. PubMed PMID: 16289727.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Attentional load of the primary task influences the frontal but not the temporal generators of mismatch negativity. AU - Restuccia,Domenico, AU - Della Marca,Giacomo, AU - Marra,Camillo, AU - Rubino,Marco, AU - Valeriani,Massimiliano, Y1 - 2005/11/09/ PY - 2005/02/10/received PY - 2005/08/14/revised PY - 2005/09/26/accepted PY - 2005/11/18/pubmed PY - 2006/2/16/medline PY - 2005/11/18/entrez SP - 891 EP - 9 JF - Brain research. Cognitive brain research JO - Brain Res Cogn Brain Res VL - 25 IS - 3 N2 - According to the model hypothesized by Näätänen and Michie, the generation of the mismatch negativity (MMN) requires a mismatch detection, taking place in temporal areas, followed by the activation of frontal generators, underlying attention switching toward the deviant stimulus. We aimed at verifying whether the activation of temporal and frontal regions is dependent on the amount of attentional resources allocable toward the deviant stimulus. We recorded event-related potentials (ERPs) in nine healthy subjects while reading and during a demanding visual task (Multiple Features Target Cancellation, MFTC). Raw data were further evaluated by Brain Electrical Source Analysis (BESA). During the Reading condition, distraction toward the unattended auditory stimuli was reflected by the enhancement of the N1 response to frequent stimuli and by the elicitation of a P3a response to deviant ones. The MMN distribution was explained by bilateral temporal dipoles. During the MFTC condition, no P3a was detected, while source analysis showed the activation of a right frontal generator. Temporal dipoles showed no change between the two conditions: we thus conclude that the earlier mismatch detection is independent on the attentional load. By contrast, the activation of a right frontal subcomponent occurred only during the high-load task, independently on any actual attention shift reflected by the P3a component. We thus discuss the hypothesis whether the right frontal MMN generator, rather than subserving a simple attention switching toward the deviant stimulus, plays a role in modulating the auditory change detection system ("contrast enhancement" model). SN - 0926-6410 UR - https://www.unboundmedicine.com/medline/citation/16289727/Attentional_load_of_the_primary_task_influences_the_frontal_but_not_the_temporal_generators_of_mismatch_negativity_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0926-6410(05)00293-4 DB - PRIME DP - Unbound Medicine ER -