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Dopamine D1 or D2 receptor antagonism within the basolateral amygdala differentially alters the acquisition of cocaine-cue associations necessary for cue-induced reinstatement of cocaine-seeking.
Neuroscience. 2006; 137(2):699-706.N

Abstract

The basolateral amygdala complex has been implicated in the formation and utilization of cocaine-cue associations in rat models of cue-induced reinstatement to cocaine-seeking behavior. We have previously demonstrated the importance of dopamine inputs to the basolateral amygdala complex in the reinstatement of cocaine-seeking behavior following chronic cocaine self-administration. Here we show that selective blockade of amygdalar dopamine D1 and D2 receptors during acquisition of cocaine-cue associations has distinctive effects on subsequent conditioned-cued cocaine-seeking behavior. Male, Sprague-Dawley rats were first trained to self-administer i.v. cocaine on a fixed ratio 1 schedule for 5 days. Subjects then received bilateral, intra-basolateral amygdala complex infusions of a dopamine D1 receptor antagonist (SCH23390, 0.25-2.0 microg/side; experiment 1), a dopamine D2 receptor antagonist (raclopride, 0.625-5.0 microg/side; experiment 2), or vehicle just prior to a single classical conditioning session, during which a light+tone cue was discretely paired with passive infusions of cocaine in the absence of lever responding. Following five additional days of cocaine self-administration and 7-10 days of extinction training, animals underwent multiple tests for cue-induced reinstatement. SCH23390 (2.0 microg/side), administered at the time of cocaine-cue association only, produced an attenuation of reinstatement to cue-induced cocaine-seeking behavior. In contrast, low doses of raclopride potentiated, while a higher dose of raclopride attenuated cue-induced reinstatement. These results demonstrate unique contributions of D1 vs. D2 receptors in mediating dopamine inputs within the basolateral amygdala complex during the formation of cocaine-stimulus associations that are critical for cue-induced reinstatement.

Authors+Show Affiliations

Department of Neurosciences, Medical University of South Carolina, 173 Ashley Avenue, Charleston, 29425, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16289883

Citation

Berglind, W J., et al. "Dopamine D1 or D2 Receptor Antagonism Within the Basolateral Amygdala Differentially Alters the Acquisition of Cocaine-cue Associations Necessary for Cue-induced Reinstatement of Cocaine-seeking." Neuroscience, vol. 137, no. 2, 2006, pp. 699-706.
Berglind WJ, Case JM, Parker MP, et al. Dopamine D1 or D2 receptor antagonism within the basolateral amygdala differentially alters the acquisition of cocaine-cue associations necessary for cue-induced reinstatement of cocaine-seeking. Neuroscience. 2006;137(2):699-706.
Berglind, W. J., Case, J. M., Parker, M. P., Fuchs, R. A., & See, R. E. (2006). Dopamine D1 or D2 receptor antagonism within the basolateral amygdala differentially alters the acquisition of cocaine-cue associations necessary for cue-induced reinstatement of cocaine-seeking. Neuroscience, 137(2), 699-706.
Berglind WJ, et al. Dopamine D1 or D2 Receptor Antagonism Within the Basolateral Amygdala Differentially Alters the Acquisition of Cocaine-cue Associations Necessary for Cue-induced Reinstatement of Cocaine-seeking. Neuroscience. 2006;137(2):699-706. PubMed PMID: 16289883.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dopamine D1 or D2 receptor antagonism within the basolateral amygdala differentially alters the acquisition of cocaine-cue associations necessary for cue-induced reinstatement of cocaine-seeking. AU - Berglind,W J, AU - Case,J M, AU - Parker,M P, AU - Fuchs,R A, AU - See,R E, Y1 - 2005/11/14/ PY - 2005/06/02/received PY - 2005/08/12/revised PY - 2005/08/30/accepted PY - 2005/11/18/pubmed PY - 2006/5/4/medline PY - 2005/11/18/entrez SP - 699 EP - 706 JF - Neuroscience JO - Neuroscience VL - 137 IS - 2 N2 - The basolateral amygdala complex has been implicated in the formation and utilization of cocaine-cue associations in rat models of cue-induced reinstatement to cocaine-seeking behavior. We have previously demonstrated the importance of dopamine inputs to the basolateral amygdala complex in the reinstatement of cocaine-seeking behavior following chronic cocaine self-administration. Here we show that selective blockade of amygdalar dopamine D1 and D2 receptors during acquisition of cocaine-cue associations has distinctive effects on subsequent conditioned-cued cocaine-seeking behavior. Male, Sprague-Dawley rats were first trained to self-administer i.v. cocaine on a fixed ratio 1 schedule for 5 days. Subjects then received bilateral, intra-basolateral amygdala complex infusions of a dopamine D1 receptor antagonist (SCH23390, 0.25-2.0 microg/side; experiment 1), a dopamine D2 receptor antagonist (raclopride, 0.625-5.0 microg/side; experiment 2), or vehicle just prior to a single classical conditioning session, during which a light+tone cue was discretely paired with passive infusions of cocaine in the absence of lever responding. Following five additional days of cocaine self-administration and 7-10 days of extinction training, animals underwent multiple tests for cue-induced reinstatement. SCH23390 (2.0 microg/side), administered at the time of cocaine-cue association only, produced an attenuation of reinstatement to cue-induced cocaine-seeking behavior. In contrast, low doses of raclopride potentiated, while a higher dose of raclopride attenuated cue-induced reinstatement. These results demonstrate unique contributions of D1 vs. D2 receptors in mediating dopamine inputs within the basolateral amygdala complex during the formation of cocaine-stimulus associations that are critical for cue-induced reinstatement. SN - 0306-4522 UR - https://www.unboundmedicine.com/medline/citation/16289883/Dopamine_D1_or_D2_receptor_antagonism_within_the_basolateral_amygdala_differentially_alters_the_acquisition_of_cocaine_cue_associations_necessary_for_cue_induced_reinstatement_of_cocaine_seeking_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306-4522(05)00990-5 DB - PRIME DP - Unbound Medicine ER -