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Enhancing the etiologic diagnosis of community-acquired pneumonia in adults using the urinary antigen assay (Binax NOW).
Int J Infect Dis. 2006 Mar; 10(2):124-8.IJ

Abstract

OBJECTIVES

Approximately 40% of community-acquired pneumonia (CAP) remains of unknown etiology. To improve the rate of detection of the causative microbiologic agent, the Binax NOW Streptococcus pneumoniae urinary antigen test (UAT) was evaluated.

DESIGN

In this prospective study, 67 adults with CAP were compared with 81 healthy patients to determine sensitivity and specificity of the UAT and its role in improving the etiologic diagnosis of CAP.

RESULTS

An etiology could be found for 22 patients (33%) using conventional methods (14 S. pneumoniae, sensitivity 64.3%, 1/81 positive UAT control urine samples, specificity 98.8%). This proportion increased to 33 patients (49%) with the addition of the urinary antigen test (p = 0.039). Pneumococcal infection was diagnosed by the UAT in 24% of our patients without an etiologic identification by conventional methods.

CONCLUSIONS

Given its excellent specificity, this test can be considered an important tool for detecting S. pneumoniae in CAP of unknown etiology, enabling the diagnosis of pneumococcal pneumonia in a quarter of cases.

Authors+Show Affiliations

Service de Médecine Interne de l'Hôpital de la Ville, rue du Chasseral 20, 2300 La Chaux-de-Fonds, Switzerland. daniel.genne@ne.chNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16290014

Citation

Genné, Daniel, et al. "Enhancing the Etiologic Diagnosis of Community-acquired Pneumonia in Adults Using the Urinary Antigen Assay (Binax NOW)." International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases, vol. 10, no. 2, 2006, pp. 124-8.
Genné D, Siegrist HH, Lienhard R. Enhancing the etiologic diagnosis of community-acquired pneumonia in adults using the urinary antigen assay (Binax NOW). Int J Infect Dis. 2006;10(2):124-8.
Genné, D., Siegrist, H. H., & Lienhard, R. (2006). Enhancing the etiologic diagnosis of community-acquired pneumonia in adults using the urinary antigen assay (Binax NOW). International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases, 10(2), 124-8.
Genné D, Siegrist HH, Lienhard R. Enhancing the Etiologic Diagnosis of Community-acquired Pneumonia in Adults Using the Urinary Antigen Assay (Binax NOW). Int J Infect Dis. 2006;10(2):124-8. PubMed PMID: 16290014.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Enhancing the etiologic diagnosis of community-acquired pneumonia in adults using the urinary antigen assay (Binax NOW). AU - Genné,Daniel, AU - Siegrist,Hans H, AU - Lienhard,Reto, Y1 - 2005/11/10/ PY - 2004/07/13/received PY - 2004/12/16/revised PY - 2005/03/07/accepted PY - 2005/11/18/pubmed PY - 2007/6/22/medline PY - 2005/11/18/entrez SP - 124 EP - 8 JF - International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases JO - Int J Infect Dis VL - 10 IS - 2 N2 - OBJECTIVES: Approximately 40% of community-acquired pneumonia (CAP) remains of unknown etiology. To improve the rate of detection of the causative microbiologic agent, the Binax NOW Streptococcus pneumoniae urinary antigen test (UAT) was evaluated. DESIGN: In this prospective study, 67 adults with CAP were compared with 81 healthy patients to determine sensitivity and specificity of the UAT and its role in improving the etiologic diagnosis of CAP. RESULTS: An etiology could be found for 22 patients (33%) using conventional methods (14 S. pneumoniae, sensitivity 64.3%, 1/81 positive UAT control urine samples, specificity 98.8%). This proportion increased to 33 patients (49%) with the addition of the urinary antigen test (p = 0.039). Pneumococcal infection was diagnosed by the UAT in 24% of our patients without an etiologic identification by conventional methods. CONCLUSIONS: Given its excellent specificity, this test can be considered an important tool for detecting S. pneumoniae in CAP of unknown etiology, enabling the diagnosis of pneumococcal pneumonia in a quarter of cases. SN - 1201-9712 UR - https://www.unboundmedicine.com/medline/citation/16290014/Enhancing_the_etiologic_diagnosis_of_community_acquired_pneumonia_in_adults_using_the_urinary_antigen_assay__Binax_NOW__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1201-9712(05)00138-4 DB - PRIME DP - Unbound Medicine ER -