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Diagnostic ability of optical coherence tomography with a normative database to detect localized retinal nerve fiber layer defects.
Ophthalmology 2005; 112(12):2157-63O

Abstract

PURPOSE

To evaluate the diagnostic ability of third-generation optical coherence tomography (Stratus OCT) with a normative database to detect localized retinal nerve fiber layer (RNFL) defects.

DESIGN

Cross-sectional study.

PARTICIPANTS

One eye of each of 55 subjects (43 normal-tension glaucoma and 12 primary open-angle glaucoma subjects) with localized, wedge-shaped RNFL defects by red-free RNFL photographs and corresponding visual field defects (mean deviation, -6.77+/-3.54; range, -1.25 to -9.20 dB).

METHODS

The segments of the borderline and outside normal limits in the RNFL thickness profile of OCT were considered to be significant RNFL defects by OCT and by comparison with their corresponding red-free RNFL photographs. The angular locations and widths of RNFL defects by OCT were compared with those of RNFL defects by red-free RNFL photographs.

MAIN OUTCOME MEASURES

Sensitivity and specificity of OCT with a normative database to detect the localized RNFL defects.

RESULTS

The mean age of the patients was 57.9+/-10.6 years (range, 25-78 years). The overall sensitivity and specificity of the OCT with a normative database for detecting localized RNFL defects were 85.9% and 97.4%, respectively. The OCT with a normative database showed good diagnostic agreement with red-free RNFL photographs (overall kappa value = 0.79). The angular locations and widths of RNFL defects by OCT were highly correlated with those of RNFL defects by red-free RNFL photographs (Pearson correlation coefficient [r] = 0.996 and 0.725, respectively).

CONCLUSIONS

The OCT with a normative database can detect localized RNFL defects with moderate sensitivity and high specificity, and shows good diagnostic agreement with red-free RNFL photographs.

Authors+Show Affiliations

Department of Ophthalmology, Seoul National University Hospital, Seoul, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16290196

Citation

Jeoung, Jin Wook, et al. "Diagnostic Ability of Optical Coherence Tomography With a Normative Database to Detect Localized Retinal Nerve Fiber Layer Defects." Ophthalmology, vol. 112, no. 12, 2005, pp. 2157-63.
Jeoung JW, Park KH, Kim TW, et al. Diagnostic ability of optical coherence tomography with a normative database to detect localized retinal nerve fiber layer defects. Ophthalmology. 2005;112(12):2157-63.
Jeoung, J. W., Park, K. H., Kim, T. W., Khwarg, S. I., & Kim, D. M. (2005). Diagnostic ability of optical coherence tomography with a normative database to detect localized retinal nerve fiber layer defects. Ophthalmology, 112(12), pp. 2157-63.
Jeoung JW, et al. Diagnostic Ability of Optical Coherence Tomography With a Normative Database to Detect Localized Retinal Nerve Fiber Layer Defects. Ophthalmology. 2005;112(12):2157-63. PubMed PMID: 16290196.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diagnostic ability of optical coherence tomography with a normative database to detect localized retinal nerve fiber layer defects. AU - Jeoung,Jin Wook, AU - Park,Ki Ho, AU - Kim,Tae Woo, AU - Khwarg,Sang In, AU - Kim,Dong Myung, Y1 - 2005/11/14/ PY - 2004/12/12/received PY - 2005/07/07/accepted PY - 2005/11/18/pubmed PY - 2005/12/15/medline PY - 2005/11/18/entrez SP - 2157 EP - 63 JF - Ophthalmology JO - Ophthalmology VL - 112 IS - 12 N2 - PURPOSE: To evaluate the diagnostic ability of third-generation optical coherence tomography (Stratus OCT) with a normative database to detect localized retinal nerve fiber layer (RNFL) defects. DESIGN: Cross-sectional study. PARTICIPANTS: One eye of each of 55 subjects (43 normal-tension glaucoma and 12 primary open-angle glaucoma subjects) with localized, wedge-shaped RNFL defects by red-free RNFL photographs and corresponding visual field defects (mean deviation, -6.77+/-3.54; range, -1.25 to -9.20 dB). METHODS: The segments of the borderline and outside normal limits in the RNFL thickness profile of OCT were considered to be significant RNFL defects by OCT and by comparison with their corresponding red-free RNFL photographs. The angular locations and widths of RNFL defects by OCT were compared with those of RNFL defects by red-free RNFL photographs. MAIN OUTCOME MEASURES: Sensitivity and specificity of OCT with a normative database to detect the localized RNFL defects. RESULTS: The mean age of the patients was 57.9+/-10.6 years (range, 25-78 years). The overall sensitivity and specificity of the OCT with a normative database for detecting localized RNFL defects were 85.9% and 97.4%, respectively. The OCT with a normative database showed good diagnostic agreement with red-free RNFL photographs (overall kappa value = 0.79). The angular locations and widths of RNFL defects by OCT were highly correlated with those of RNFL defects by red-free RNFL photographs (Pearson correlation coefficient [r] = 0.996 and 0.725, respectively). CONCLUSIONS: The OCT with a normative database can detect localized RNFL defects with moderate sensitivity and high specificity, and shows good diagnostic agreement with red-free RNFL photographs. SN - 1549-4713 UR - https://www.unboundmedicine.com/medline/citation/16290196/Diagnostic_ability_of_optical_coherence_tomography_with_a_normative_database_to_detect_localized_retinal_nerve_fiber_layer_defects_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(05)00912-7 DB - PRIME DP - Unbound Medicine ER -