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The effect of atorvastatin on heart rate variability and lipoproteins in patients treated with coronary bypass surgery.
Int J Cardiol. 2006 Aug 28; 111(3):436-41.IJ

Abstract

Statins reduce mortality in patients with coronary heart disease (CHD). An antiarrhythmic effect of statins has been suggested and reported as a possible contributing mechanism. The aim of this study was to examine whether atorvastatin had any effect on heart rate variability (HRV), an important predictor of sudden cardiac death. Eighty patients previously treated with coronary artery bypass grafting (CABG) were studied. The study was designed as a randomized, placebo-controlled, double blinded crossover study. The patients were randomized in two groups, and were treated with 80 mg atorvastatin or placebo for 6 weeks before crossing over to the opposite treatment for another 6 weeks. There was no washout between treatments. Twenty-four-hour Holter recording and plasma lipids and lipoprotein measurements were performed at baseline and after each 6-week period. There was no change in HRV indices after treatment with 80 mg atorvastatin for 6 weeks. A significant reduction in total cholesterol (46%, p</=0.001), LDL cholesterol (61%, p</=0.001) and triglycerides (35%, p</=0.001) were observed during treatment with atorvastatin. Therapy with 80 mg atorvastatin daily for 6 weeks reduced total cholesterol, LDL cholesterol and triglycerides significantly, while there was no effect on 24-h HRV indices. The study therefore does not lend support for any effect of atorvastatin on HRV after 6 weeks of treatment in patients treated with CABG.

Authors+Show Affiliations

Department of Cardiology, Center for Cardiovascular Research, Aalborg Hospital, Arhus University Hospital, Denmark. samriahi@dadlnet.dkNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16290290

Citation

Riahi, Sam, et al. "The Effect of Atorvastatin On Heart Rate Variability and Lipoproteins in Patients Treated With Coronary Bypass Surgery." International Journal of Cardiology, vol. 111, no. 3, 2006, pp. 436-41.
Riahi S, Schmidt EB, Amanavicius N, et al. The effect of atorvastatin on heart rate variability and lipoproteins in patients treated with coronary bypass surgery. Int J Cardiol. 2006;111(3):436-41.
Riahi, S., Schmidt, E. B., Amanavicius, N., Karmisholt, J., Jensen, H. S., Christoffersen, R. P., Niebuhr, U., Christensen, J. H., & Toft, E. (2006). The effect of atorvastatin on heart rate variability and lipoproteins in patients treated with coronary bypass surgery. International Journal of Cardiology, 111(3), 436-41.
Riahi S, et al. The Effect of Atorvastatin On Heart Rate Variability and Lipoproteins in Patients Treated With Coronary Bypass Surgery. Int J Cardiol. 2006 Aug 28;111(3):436-41. PubMed PMID: 16290290.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of atorvastatin on heart rate variability and lipoproteins in patients treated with coronary bypass surgery. AU - Riahi,Sam, AU - Schmidt,Erik Berg, AU - Amanavicius,Nerijus, AU - Karmisholt,Jesper, AU - Jensen,Hanne Sortsøe, AU - Christoffersen,Rasmus Peter, AU - Niebuhr,Uffe, AU - Christensen,Jeppe Hagstrup, AU - Toft,Egon, Y1 - 2005/11/14/ PY - 2005/04/22/received PY - 2005/08/10/revised PY - 2005/08/20/accepted PY - 2005/11/18/pubmed PY - 2007/1/4/medline PY - 2005/11/18/entrez SP - 436 EP - 41 JF - International journal of cardiology JO - Int J Cardiol VL - 111 IS - 3 N2 - Statins reduce mortality in patients with coronary heart disease (CHD). An antiarrhythmic effect of statins has been suggested and reported as a possible contributing mechanism. The aim of this study was to examine whether atorvastatin had any effect on heart rate variability (HRV), an important predictor of sudden cardiac death. Eighty patients previously treated with coronary artery bypass grafting (CABG) were studied. The study was designed as a randomized, placebo-controlled, double blinded crossover study. The patients were randomized in two groups, and were treated with 80 mg atorvastatin or placebo for 6 weeks before crossing over to the opposite treatment for another 6 weeks. There was no washout between treatments. Twenty-four-hour Holter recording and plasma lipids and lipoprotein measurements were performed at baseline and after each 6-week period. There was no change in HRV indices after treatment with 80 mg atorvastatin for 6 weeks. A significant reduction in total cholesterol (46%, p</=0.001), LDL cholesterol (61%, p</=0.001) and triglycerides (35%, p</=0.001) were observed during treatment with atorvastatin. Therapy with 80 mg atorvastatin daily for 6 weeks reduced total cholesterol, LDL cholesterol and triglycerides significantly, while there was no effect on 24-h HRV indices. The study therefore does not lend support for any effect of atorvastatin on HRV after 6 weeks of treatment in patients treated with CABG. SN - 0167-5273 UR - https://www.unboundmedicine.com/medline/citation/16290290/The_effect_of_atorvastatin_on_heart_rate_variability_and_lipoproteins_in_patients_treated_with_coronary_bypass_surgery_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0167-5273(05)01160-5 DB - PRIME DP - Unbound Medicine ER -