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Environmental tobacco smoke (ETS) exposure in children with asthma-relation between lead and cadmium, and cotinine concentrations in urine.
Respir Med. 2005 Dec; 99(12):1521-7.RM

Abstract

Exposure to heavy metals from environmental tobacco smoke (ETS) was investigated in 23 children with asthma (8.4+/-3.7 yr). ETS exposure was assessed by an inquiry data-based exposure index, the urinary concentration of cotinine (U-cotinine; a major nicotine metabolite) and the house dust (fine and coarse fractions) concentrations of nicotine at home. The corresponding concentrations of the heavy metals cadmium and lead in dust and urine (U-Cd; U-Pb) were determined in the same samples. There were strong associations between the ETS exposure index and U-cotinine (r(s)=0.62; P<0.002) and nicotine in house dust (r(s)=0.77; P<0.001). There was a strong positive correlation between lead and cadmium concentrations in both fine (r(s)=0.86; P<0.001) and coarse dust (r(s)=0.57; P=0.02). Although, there was a tendency for a relation between nicotine and lead concentrations in fine dust (r(s)=0.52; P=0.06), no other significant associations were found between house dust metals and nicotine concentrations. U-Cd correlated well with U-cotinine (r(s)=0.50; P=0.02). Further, U-Pb were associated with U-cotinine, however not statistically significant (r(s)=0.41; P=0.06). A probable explanation is a direct inhalation of side-stream smoke containing heavy metals and/ or an increased pulmonary uptake, due to a small airways disease in children with asthma.

Authors+Show Affiliations

Unit of Preventive Medicine, Heart and Lung Center, Lund University Hospital, SE-221 85 Lund, Sweden. stefan.willers@skane.seNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16291074

Citation

Willers, Stefan, et al. "Environmental Tobacco Smoke (ETS) Exposure in Children With Asthma-relation Between Lead and Cadmium, and Cotinine Concentrations in Urine." Respiratory Medicine, vol. 99, no. 12, 2005, pp. 1521-7.
Willers S, Gerhardsson L, Lundh T. Environmental tobacco smoke (ETS) exposure in children with asthma-relation between lead and cadmium, and cotinine concentrations in urine. Respir Med. 2005;99(12):1521-7.
Willers, S., Gerhardsson, L., & Lundh, T. (2005). Environmental tobacco smoke (ETS) exposure in children with asthma-relation between lead and cadmium, and cotinine concentrations in urine. Respiratory Medicine, 99(12), 1521-7.
Willers S, Gerhardsson L, Lundh T. Environmental Tobacco Smoke (ETS) Exposure in Children With Asthma-relation Between Lead and Cadmium, and Cotinine Concentrations in Urine. Respir Med. 2005;99(12):1521-7. PubMed PMID: 16291074.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Environmental tobacco smoke (ETS) exposure in children with asthma-relation between lead and cadmium, and cotinine concentrations in urine. AU - Willers,Stefan, AU - Gerhardsson,Lars, AU - Lundh,Thomas, Y1 - 2005/04/26/ PY - 2005/01/28/received PY - 2005/03/13/accepted PY - 2005/11/18/pubmed PY - 2006/4/18/medline PY - 2005/11/18/entrez SP - 1521 EP - 7 JF - Respiratory medicine JO - Respir Med VL - 99 IS - 12 N2 - Exposure to heavy metals from environmental tobacco smoke (ETS) was investigated in 23 children with asthma (8.4+/-3.7 yr). ETS exposure was assessed by an inquiry data-based exposure index, the urinary concentration of cotinine (U-cotinine; a major nicotine metabolite) and the house dust (fine and coarse fractions) concentrations of nicotine at home. The corresponding concentrations of the heavy metals cadmium and lead in dust and urine (U-Cd; U-Pb) were determined in the same samples. There were strong associations between the ETS exposure index and U-cotinine (r(s)=0.62; P<0.002) and nicotine in house dust (r(s)=0.77; P<0.001). There was a strong positive correlation between lead and cadmium concentrations in both fine (r(s)=0.86; P<0.001) and coarse dust (r(s)=0.57; P=0.02). Although, there was a tendency for a relation between nicotine and lead concentrations in fine dust (r(s)=0.52; P=0.06), no other significant associations were found between house dust metals and nicotine concentrations. U-Cd correlated well with U-cotinine (r(s)=0.50; P=0.02). Further, U-Pb were associated with U-cotinine, however not statistically significant (r(s)=0.41; P=0.06). A probable explanation is a direct inhalation of side-stream smoke containing heavy metals and/ or an increased pulmonary uptake, due to a small airways disease in children with asthma. SN - 0954-6111 UR - https://www.unboundmedicine.com/medline/citation/16291074/Environmental_tobacco_smoke__ETS__exposure_in_children_with_asthma_relation_between_lead_and_cadmium_and_cotinine_concentrations_in_urine_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0954-6111(05)00115-0 DB - PRIME DP - Unbound Medicine ER -