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Dexamethasone-eluting stents and plasma concentrations of adhesion molecules in patients with unstable coronary syndromes: results of the historically controlled SESAME study.
Clin Ther. 2005 Sep; 27(9):1411-9.CT

Abstract

BACKGROUND

Plasma concentrations of intercellular adhesion molecule-1 [ICAM-1], vascular cell adhesion molecule-1 [VCAM-1], and E-selectin may increase after percutaneous coronary intervention (PCI).

OBJECTIVE

The aim of this study was to assess whether anti-inflammatory treatment with steroid-eluting stents influenced concentrations of adhesion molecules after PCI in patients with unstable coronary syndromes.

METHODS

Consecutive patients with unstable coronary syndromes who were prospectively assigned to undergo implantation of a dexamethasone-eluting stent were compared with a control group of consecutive historical patients who received a similar non-drugeluting stent in the period immediately preceding availability of the steroid-eluting stents. Circulating concentrations of adhesion molecules were measured before the procedure and at 6 and 24 hours after implantation.

RESULTS

The study included 50 patients who received the dexamethasone-eluting stent (41 men, 9 women; mean [SD] age, 60 [9] years) and 50 historical controls who received the non-drug-eluting stent (40 men, 10 women; mean age, 63 [11] years). Baseline values for the adhesion molecules were similar in the 2 groups: in patients who received the dexamethasone-eluting stent, mean (SD) values were 210 (41) ng/mL for ICAM-1, 637 (119) ng/mL for VCAM-1, and 46 (9) ng/mL for E-selectin; in the control group, the corresponding values were 218 (42), 618 (140), and 43 (10) ng/mL. Circulating concentrations at 24 hours were significantly lower in patients receiving the drug-eluting stent compared with controls for both ICAM-1 (279 [49] vs 338 [60] ng/mL, respectively; P = 0.001) and VCAM-1 (772 [163] vs 896 [207] ng/mL; P = 0.004). There was no significant between-group difference in E-selectin concentrations at 24 hours (60 [10] vs 56 [11] ng/mL).

CONCLUSION

In this study, dexamethasone-eluting stents reduced plasma concentrations of ICAM-1 and VCAM-1 after PCI in patients with unstable coronary syndromes compared with historical controls.

Authors+Show Affiliations

Department of Cardiovascular Sciences, Campus Bio-Medico University, Rome, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article

Language

eng

PubMed ID

16291414

Citation

Patti, Giuseppe, et al. "Dexamethasone-eluting Stents and Plasma Concentrations of Adhesion Molecules in Patients With Unstable Coronary Syndromes: Results of the Historically Controlled SESAME Study." Clinical Therapeutics, vol. 27, no. 9, 2005, pp. 1411-9.
Patti G, Chello M, Pasceri V, et al. Dexamethasone-eluting stents and plasma concentrations of adhesion molecules in patients with unstable coronary syndromes: results of the historically controlled SESAME study. Clin Ther. 2005;27(9):1411-9.
Patti, G., Chello, M., Pasceri, V., Colonna, D., Carminati, P., Covino, E., & Di Germano, S. (2005). Dexamethasone-eluting stents and plasma concentrations of adhesion molecules in patients with unstable coronary syndromes: results of the historically controlled SESAME study. Clinical Therapeutics, 27(9), 1411-9.
Patti G, et al. Dexamethasone-eluting Stents and Plasma Concentrations of Adhesion Molecules in Patients With Unstable Coronary Syndromes: Results of the Historically Controlled SESAME Study. Clin Ther. 2005;27(9):1411-9. PubMed PMID: 16291414.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dexamethasone-eluting stents and plasma concentrations of adhesion molecules in patients with unstable coronary syndromes: results of the historically controlled SESAME study. AU - Patti,Giuseppe, AU - Chello,Massimo, AU - Pasceri,Vincenzo, AU - Colonna,Diego, AU - Carminati,Patrizia, AU - Covino,Elvio, AU - Di Germano,Sciascio, PY - 2005/07/14/accepted PY - 2005/11/18/pubmed PY - 2006/11/14/medline PY - 2005/11/18/entrez SP - 1411 EP - 9 JF - Clinical therapeutics JO - Clin Ther VL - 27 IS - 9 N2 - BACKGROUND: Plasma concentrations of intercellular adhesion molecule-1 [ICAM-1], vascular cell adhesion molecule-1 [VCAM-1], and E-selectin may increase after percutaneous coronary intervention (PCI). OBJECTIVE: The aim of this study was to assess whether anti-inflammatory treatment with steroid-eluting stents influenced concentrations of adhesion molecules after PCI in patients with unstable coronary syndromes. METHODS: Consecutive patients with unstable coronary syndromes who were prospectively assigned to undergo implantation of a dexamethasone-eluting stent were compared with a control group of consecutive historical patients who received a similar non-drugeluting stent in the period immediately preceding availability of the steroid-eluting stents. Circulating concentrations of adhesion molecules were measured before the procedure and at 6 and 24 hours after implantation. RESULTS: The study included 50 patients who received the dexamethasone-eluting stent (41 men, 9 women; mean [SD] age, 60 [9] years) and 50 historical controls who received the non-drug-eluting stent (40 men, 10 women; mean age, 63 [11] years). Baseline values for the adhesion molecules were similar in the 2 groups: in patients who received the dexamethasone-eluting stent, mean (SD) values were 210 (41) ng/mL for ICAM-1, 637 (119) ng/mL for VCAM-1, and 46 (9) ng/mL for E-selectin; in the control group, the corresponding values were 218 (42), 618 (140), and 43 (10) ng/mL. Circulating concentrations at 24 hours were significantly lower in patients receiving the drug-eluting stent compared with controls for both ICAM-1 (279 [49] vs 338 [60] ng/mL, respectively; P = 0.001) and VCAM-1 (772 [163] vs 896 [207] ng/mL; P = 0.004). There was no significant between-group difference in E-selectin concentrations at 24 hours (60 [10] vs 56 [11] ng/mL). CONCLUSION: In this study, dexamethasone-eluting stents reduced plasma concentrations of ICAM-1 and VCAM-1 after PCI in patients with unstable coronary syndromes compared with historical controls. SN - 0149-2918 UR - https://www.unboundmedicine.com/medline/citation/16291414/Dexamethasone_eluting_stents_and_plasma_concentrations_of_adhesion_molecules_in_patients_with_unstable_coronary_syndromes:_results_of_the_historically_controlled_SESAME_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0149-2918(05)00174-8 DB - PRIME DP - Unbound Medicine ER -