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Acute fulminant visceral leishmaniasis in children--a report of two cases.
Indian J Pathol Microbiol. 2004 Jul; 47(3):428-30.IJ

Abstract

Kala-azar usually presents in older children and young adults with insidious onset of fever, splenomegaly and pancytopenia. Characteristic L.D. bodies in bone marrow or splenic aspirates are diagnostic of kala-azar. We report two cases of visceral leishmaniasis in children-1 1/2 and 10 year old with unusual presentation and fulminant course. In case 1 a female presented with fever, jaundice and bleeding manifestations. Peripheral smear revealed L.D. bodies in neutrophils as well as monocytes. The liver function tests were deranged. The child died within three days due to respiratory arrest. Case 2 was a boy who presented with fever and altered sensorium with deranged liver function tests. The patient expired within three days due to hepatic encephalopathy. Thus, it is important to consider the diagnosis of Kala-azar even when the presenting complaints are atypical and institute diagnostic and therapeutic measures early to prevent mortality.

Authors+Show Affiliations

Pahwa R
Departments of Pathology, Maulana Azad Medical College and associated L.N., G.B. Pant Hospitals, New Delhi. rumaarora1@rediffmail.com
Gupta SK
No affiliation info available
Singh T
No affiliation info available
Nigam S
No affiliation info available

MeSH

AnimalsBone MarrowChildFemaleHumansInfantLeishmania donovaniLeishmaniasis, VisceralMaleNecrosis

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

16295448

Citation

Pahwa, Ruma, et al. "Acute Fulminant Visceral Leishmaniasis in Children--a Report of Two Cases." Indian Journal of Pathology & Microbiology, vol. 47, no. 3, 2004, pp. 428-30.
Pahwa R, Gupta SK, Singh T, et al. Acute fulminant visceral leishmaniasis in children--a report of two cases. Indian J Pathol Microbiol. 2004;47(3):428-30.
Pahwa, R., Gupta, S. K., Singh, T., & Nigam, S. (2004). Acute fulminant visceral leishmaniasis in children--a report of two cases. Indian Journal of Pathology & Microbiology, 47(3), 428-30.
Pahwa R, et al. Acute Fulminant Visceral Leishmaniasis in Children--a Report of Two Cases. Indian J Pathol Microbiol. 2004;47(3):428-30. PubMed PMID: 16295448.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acute fulminant visceral leishmaniasis in children--a report of two cases. AU - Pahwa,Ruma, AU - Gupta,Sanjeev K, AU - Singh,Tejinder, AU - Nigam,Sonu, PY - 2005/11/22/pubmed PY - 2006/1/25/medline PY - 2005/11/22/entrez SP - 428 EP - 30 JF - Indian journal of pathology & microbiology JO - Indian J Pathol Microbiol VL - 47 IS - 3 N2 - Kala-azar usually presents in older children and young adults with insidious onset of fever, splenomegaly and pancytopenia. Characteristic L.D. bodies in bone marrow or splenic aspirates are diagnostic of kala-azar. We report two cases of visceral leishmaniasis in children-1 1/2 and 10 year old with unusual presentation and fulminant course. In case 1 a female presented with fever, jaundice and bleeding manifestations. Peripheral smear revealed L.D. bodies in neutrophils as well as monocytes. The liver function tests were deranged. The child died within three days due to respiratory arrest. Case 2 was a boy who presented with fever and altered sensorium with deranged liver function tests. The patient expired within three days due to hepatic encephalopathy. Thus, it is important to consider the diagnosis of Kala-azar even when the presenting complaints are atypical and institute diagnostic and therapeutic measures early to prevent mortality. SN - 0377-4929 UR - https://www.unboundmedicine.com/medline/citation/16295448/Acute_fulminant_visceral_leishmaniasis_in_children__a_report_of_two_cases_ DB - PRIME DP - Unbound Medicine ER -