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Closed-loop insulin delivery - what lies between where we are and where we are going?
Expert Opin Drug Deliv. 2005 Mar; 2(2):353-62.EO

Abstract

Closed-loop insulin delivery in individuals with diabetes can potentially lead to near-normal glucose profiles. To this end, existing subcutaneous glucose sensors and external insulin pumps can be linked with an insulin delivery algorithm to create a completely automated closed-loop system. This paper reviews current research into the development of such a system, with particular emphasis on creating a system emulating the physiological properties of the beta-cell. Issues related to using subcutaneous interstitial fluid for glucose sensing and insulin delivery are reviewed. Criteria for optimising the system are discussed using historical data. Existing strategies for open-loop pump therapy are presented with the objective of defining a path to advance from the existing physician/patient determined insulin therapy to a completely automated system.

Authors+Show Affiliations

Medtronic MiniMed, Northridge, CA 91325, USA. garry.steil@Medtronic.comNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

16296759

Citation

Steil, Garry M., and Kerstin Rebrin. "Closed-loop Insulin Delivery - what Lies Between Where We Are and Where We Are Going?" Expert Opinion On Drug Delivery, vol. 2, no. 2, 2005, pp. 353-62.
Steil GM, Rebrin K. Closed-loop insulin delivery - what lies between where we are and where we are going? Expert Opin Drug Deliv. 2005;2(2):353-62.
Steil, G. M., & Rebrin, K. (2005). Closed-loop insulin delivery - what lies between where we are and where we are going? Expert Opinion On Drug Delivery, 2(2), 353-62.
Steil GM, Rebrin K. Closed-loop Insulin Delivery - what Lies Between Where We Are and Where We Are Going. Expert Opin Drug Deliv. 2005;2(2):353-62. PubMed PMID: 16296759.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Closed-loop insulin delivery - what lies between where we are and where we are going? AU - Steil,Garry M, AU - Rebrin,Kerstin, PY - 2005/11/22/pubmed PY - 2006/9/16/medline PY - 2005/11/22/entrez SP - 353 EP - 62 JF - Expert opinion on drug delivery JO - Expert Opin Drug Deliv VL - 2 IS - 2 N2 - Closed-loop insulin delivery in individuals with diabetes can potentially lead to near-normal glucose profiles. To this end, existing subcutaneous glucose sensors and external insulin pumps can be linked with an insulin delivery algorithm to create a completely automated closed-loop system. This paper reviews current research into the development of such a system, with particular emphasis on creating a system emulating the physiological properties of the beta-cell. Issues related to using subcutaneous interstitial fluid for glucose sensing and insulin delivery are reviewed. Criteria for optimising the system are discussed using historical data. Existing strategies for open-loop pump therapy are presented with the objective of defining a path to advance from the existing physician/patient determined insulin therapy to a completely automated system. SN - 1742-5247 UR - https://www.unboundmedicine.com/medline/citation/16296759/Closed_loop_insulin_delivery___what_lies_between_where_we_are_and_where_we_are_going L2 - https://www.tandfonline.com/doi/full/10.1517/17425247.2.2.353 DB - PRIME DP - Unbound Medicine ER -