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Consumption of sweetened dried cranberries versus unsweetened raisins for inhibition of uropathogenic Escherichia coli adhesion in human urine: a pilot study.
J Altern Complement Med. 2005 Oct; 11(5):875-8.JA

Abstract

OBJECTIVES

The aim of this study was to determine whether consumption of sweetened dried cranberries elicits urinary anti-adherence properties against Escherichia coli as previously demonstrated with cranberry juice and/or sweetened cranberry juice cocktail, compared to unsweetened raisins.

DESIGN

Uropathogenic E. coli isolates were obtained from five women with culture-confirmed urinary tract infections (UTIs). Four urine samples were collected from each subject. The first urine sample was collected before any study intervention. The second urine sample was collected 2-5 hours after consumption of one box (42.5 g) of raisins. The third urine sample was collected 5-7 days later. The final urine sample was collected 2-5 hours after consumption of approximately 42.5 g of dried cranberries.

MATERIALS AND METHODS

E. coli isolates were incubated separately in each of the four urine samples collected from the five subjects. Bacteria were harvested from the urine and tested for the ability to prevent adhesion of P-fimbriated E. coli bacteria using a mannose-resistant hemagglutination assay with human red blood cells (A1, Rh+).

RESULTS

Of the urine samples collected after dried cranberry consumption, one demonstrated 50% antiadherence activity, two demonstrated 25% activity, and two did not show any increased activity. None of the control urine samples and none of the postraisin consumption samples demonstrated any inhibitory activity.

CONCLUSIONS

Data from this pilot study on only five subjects suggest that consumption of a single serving of sweetened dried cranberries may elicit bacterial antiadhesion activity in human urine, whereas consumption of a single serving of raisins does not. Further studies are needed to verify the antiadhesion effect of sweetened dried cranberries. In addition, dose-response and pharmacokinetics of the active compounds in the dried cranberries need to be determined. If clinical research is positive, dried cranberries could potentially be a viable alternative to cranberry juice consumption for prevention of UTIs.

Authors+Show Affiliations

Brigham & Women's Hospital, Boston, MA., Harvard Medical School, Boston, MA, USA. jagreenberg@partners.orgNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16296921

Citation

Greenberg, James A., et al. "Consumption of Sweetened Dried Cranberries Versus Unsweetened Raisins for Inhibition of Uropathogenic Escherichia Coli Adhesion in Human Urine: a Pilot Study." Journal of Alternative and Complementary Medicine (New York, N.Y.), vol. 11, no. 5, 2005, pp. 875-8.
Greenberg JA, Newmann SJ, Howell AB. Consumption of sweetened dried cranberries versus unsweetened raisins for inhibition of uropathogenic Escherichia coli adhesion in human urine: a pilot study. J Altern Complement Med. 2005;11(5):875-8.
Greenberg, J. A., Newmann, S. J., & Howell, A. B. (2005). Consumption of sweetened dried cranberries versus unsweetened raisins for inhibition of uropathogenic Escherichia coli adhesion in human urine: a pilot study. Journal of Alternative and Complementary Medicine (New York, N.Y.), 11(5), 875-8.
Greenberg JA, Newmann SJ, Howell AB. Consumption of Sweetened Dried Cranberries Versus Unsweetened Raisins for Inhibition of Uropathogenic Escherichia Coli Adhesion in Human Urine: a Pilot Study. J Altern Complement Med. 2005;11(5):875-8. PubMed PMID: 16296921.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Consumption of sweetened dried cranberries versus unsweetened raisins for inhibition of uropathogenic Escherichia coli adhesion in human urine: a pilot study. AU - Greenberg,James A, AU - Newmann,Sara J, AU - Howell,Amy B, PY - 2005/11/22/pubmed PY - 2006/5/2/medline PY - 2005/11/22/entrez SP - 875 EP - 8 JF - Journal of alternative and complementary medicine (New York, N.Y.) JO - J Altern Complement Med VL - 11 IS - 5 N2 - OBJECTIVES: The aim of this study was to determine whether consumption of sweetened dried cranberries elicits urinary anti-adherence properties against Escherichia coli as previously demonstrated with cranberry juice and/or sweetened cranberry juice cocktail, compared to unsweetened raisins. DESIGN: Uropathogenic E. coli isolates were obtained from five women with culture-confirmed urinary tract infections (UTIs). Four urine samples were collected from each subject. The first urine sample was collected before any study intervention. The second urine sample was collected 2-5 hours after consumption of one box (42.5 g) of raisins. The third urine sample was collected 5-7 days later. The final urine sample was collected 2-5 hours after consumption of approximately 42.5 g of dried cranberries. MATERIALS AND METHODS: E. coli isolates were incubated separately in each of the four urine samples collected from the five subjects. Bacteria were harvested from the urine and tested for the ability to prevent adhesion of P-fimbriated E. coli bacteria using a mannose-resistant hemagglutination assay with human red blood cells (A1, Rh+). RESULTS: Of the urine samples collected after dried cranberry consumption, one demonstrated 50% antiadherence activity, two demonstrated 25% activity, and two did not show any increased activity. None of the control urine samples and none of the postraisin consumption samples demonstrated any inhibitory activity. CONCLUSIONS: Data from this pilot study on only five subjects suggest that consumption of a single serving of sweetened dried cranberries may elicit bacterial antiadhesion activity in human urine, whereas consumption of a single serving of raisins does not. Further studies are needed to verify the antiadhesion effect of sweetened dried cranberries. In addition, dose-response and pharmacokinetics of the active compounds in the dried cranberries need to be determined. If clinical research is positive, dried cranberries could potentially be a viable alternative to cranberry juice consumption for prevention of UTIs. SN - 1075-5535 UR - https://www.unboundmedicine.com/medline/citation/16296921/Consumption_of_sweetened_dried_cranberries_versus_unsweetened_raisins_for_inhibition_of_uropathogenic_Escherichia_coli_adhesion_in_human_urine:_a_pilot_study_ L2 - https://www.liebertpub.com/doi/10.1089/acm.2005.11.875?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -