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Histamine ameliorates spatial memory deficits induced by MK-801 infusion into ventral hippocampus as evaluated by radial maze task in rats.
Acta Pharmacol Sin. 2005 Dec; 26(12):1448-53.AP

Abstract

AIM

To investigate the role of histamine in memory deficits induced by MK-801 infusion into the ventral hippocampus in rats.

METHODS

An 8-arm radial maze (4 arms baited) was used to assess spatial memory.

RESULTS

Bilateral ventral intrahippocampal (ih) infusion of MK-801 (0.3 microg/site), an N-methyl-D-aspartate (NMDA) antagonist, impaired the retrieval process in both working memory and reference memory. Intrahippocampal injection of histamine (25 or 50 ng/site) or intraperitoneal (ip) injection of histidine (25, 50 or 100 mg/kg) markedly ameliorated the spatial memory deficits induced by MK-801. Both the histamine H1 antagonist pyrilamine (0.5 or 1.0 microg/site, ih) and the H2 antagonist cimetidine (2.5 microg/site, ih) abolished the ameliorating effect of histidine (100 mg/kg, ip) on reference memory deficits, but not that on working memory deficits induced by MK-801.

CONCLUSION

The results indicate that histamine in the ventral hippocampus can ameliorate MK-801-induced spatial memory deficits, and that histamine's effect on reference memory is mediated by postsynaptic histamine H1 and H2 receptors.

Authors+Show Affiliations

Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou 310031, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16297342

Citation

Xu, Li-Sha, et al. "Histamine Ameliorates Spatial Memory Deficits Induced By MK-801 Infusion Into Ventral Hippocampus as Evaluated By Radial Maze Task in Rats." Acta Pharmacologica Sinica, vol. 26, no. 12, 2005, pp. 1448-53.
Xu LS, Yang LX, Hu WW, et al. Histamine ameliorates spatial memory deficits induced by MK-801 infusion into ventral hippocampus as evaluated by radial maze task in rats. Acta Pharmacol Sin. 2005;26(12):1448-53.
Xu, L. S., Yang, L. X., Hu, W. W., Yu, X., Ma, L., Liu, L. Y., Wei, E. Q., & Chen, Z. (2005). Histamine ameliorates spatial memory deficits induced by MK-801 infusion into ventral hippocampus as evaluated by radial maze task in rats. Acta Pharmacologica Sinica, 26(12), 1448-53.
Xu LS, et al. Histamine Ameliorates Spatial Memory Deficits Induced By MK-801 Infusion Into Ventral Hippocampus as Evaluated By Radial Maze Task in Rats. Acta Pharmacol Sin. 2005;26(12):1448-53. PubMed PMID: 16297342.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Histamine ameliorates spatial memory deficits induced by MK-801 infusion into ventral hippocampus as evaluated by radial maze task in rats. AU - Xu,Li-Sha, AU - Yang,Li-Xia, AU - Hu,Wei-Wei, AU - Yu,Xiao, AU - Ma,Li, AU - Liu,Lu-Ying, AU - Wei,Er-Qing, AU - Chen,Zhong, PY - 2005/11/22/pubmed PY - 2007/9/5/medline PY - 2005/11/22/entrez SP - 1448 EP - 53 JF - Acta pharmacologica Sinica JO - Acta Pharmacol Sin VL - 26 IS - 12 N2 - AIM: To investigate the role of histamine in memory deficits induced by MK-801 infusion into the ventral hippocampus in rats. METHODS: An 8-arm radial maze (4 arms baited) was used to assess spatial memory. RESULTS: Bilateral ventral intrahippocampal (ih) infusion of MK-801 (0.3 microg/site), an N-methyl-D-aspartate (NMDA) antagonist, impaired the retrieval process in both working memory and reference memory. Intrahippocampal injection of histamine (25 or 50 ng/site) or intraperitoneal (ip) injection of histidine (25, 50 or 100 mg/kg) markedly ameliorated the spatial memory deficits induced by MK-801. Both the histamine H1 antagonist pyrilamine (0.5 or 1.0 microg/site, ih) and the H2 antagonist cimetidine (2.5 microg/site, ih) abolished the ameliorating effect of histidine (100 mg/kg, ip) on reference memory deficits, but not that on working memory deficits induced by MK-801. CONCLUSION: The results indicate that histamine in the ventral hippocampus can ameliorate MK-801-induced spatial memory deficits, and that histamine's effect on reference memory is mediated by postsynaptic histamine H1 and H2 receptors. SN - 1671-4083 UR - https://www.unboundmedicine.com/medline/citation/16297342/Histamine_ameliorates_spatial_memory_deficits_induced_by_MK_801_infusion_into_ventral_hippocampus_as_evaluated_by_radial_maze_task_in_rats_ L2 - https://doi.org/10.1111/j.1745-7254.2005.00229.x DB - PRIME DP - Unbound Medicine ER -