Tags

Type your tag names separated by a space and hit enter

Relationship between insulin resistance and left ventricular diastolic dysfunction in patients with impaired glucose tolerance and type 2 diabetes.
Int J Cardiol. 2006 Jun 16; 110(2):206-11.IJ

Abstract

AIM

The aim of this study was to explore the relationship between insulin resistance (IR) and the left ventricular diastolic function in patients with type 2 diabetes and subjects with impaired glucose tolerance (IGT).

METHODS

The study included 119 subjects who underwent oral glucose tolerance test (OGTT). IR was assessed using Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) and Quantitative Insulin Sensitivity Check Index (QUICKI). Left ventricular diastolic function was assessed using trans-thoracic Doppler echocardiography.

RESULTS

Based on the OGTT results, 29 subjects had normal glucose tolerance (NGT), 20 subjects had impaired glucose tolerance (IGT), and 70 patients had type 2 diabetes. There were significant differences among the patients in groups with NGT, IGT and diabetes regarding HOMA-IR (4.20 +/- 1.20 vs. 6.45 +/- 3.83 vs. 8.70 +/- 6.26; P < 0.001) and QUICKI (0.54 +/- 0.11 vs. 0.49 +/- 0.08 vs. 0.47 +/- 0.08; P < 0.001). In subjects with NGT, IGT and patients with diabetes, the pulsed Doppler transmitral variables were: E-wave (0.72 +/- 0.16 cm/s vs. 0.62 +/- 0.13 cm/s vs. 0.58 +/- 0.17 cm/s; P < 0.001), A-wave (0.61 +/- 0.13 cm/s vs. 0.62 +/- 0.11 cm/s vs. 0.71+/- 0.14 cm/s; P = 0.006) and E/A ratio (1.22 +/- 0.33 vs. 1.02 +/- 0.24 vs. 0.85 +/- 0.26; p < 0.001). The proportion of subjects with an E/A ratio <1 was 27.6% in the group with NGT, 55% in the group with IGT and 75.7% in the group with diabetes (P < 0.001). The E/A ratio correlated with HOMA-IR (r = -0.30, p = 0.001) and QUICKI (r = 0.37, p < 0.0001). Multiple linear regression model showed that IR (assessed by QUICKI) was an independent correlate of diastolic dysfunction (P = 0.034).

CONCLUSIONS

In subjects with impaired glucose tolerance and patients with type 2 diabetes, insulin resistance is associated with impaired diastolic function of the left ventricle.

Authors+Show Affiliations

Service of Cardiology, Clinic of Internal Medicine, University Clinical Centre of Kosova, Prishtina. ganibajraktari@yahoo.co.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16297997

Citation

Bajraktari, Gani, et al. "Relationship Between Insulin Resistance and Left Ventricular Diastolic Dysfunction in Patients With Impaired Glucose Tolerance and Type 2 Diabetes." International Journal of Cardiology, vol. 110, no. 2, 2006, pp. 206-11.
Bajraktari G, Koltai MS, Ademaj F, et al. Relationship between insulin resistance and left ventricular diastolic dysfunction in patients with impaired glucose tolerance and type 2 diabetes. Int J Cardiol. 2006;110(2):206-11.
Bajraktari, G., Koltai, M. S., Ademaj, F., Rexhepaj, N., Qirko, S., Ndrepepa, G., & Elezi, S. (2006). Relationship between insulin resistance and left ventricular diastolic dysfunction in patients with impaired glucose tolerance and type 2 diabetes. International Journal of Cardiology, 110(2), 206-11.
Bajraktari G, et al. Relationship Between Insulin Resistance and Left Ventricular Diastolic Dysfunction in Patients With Impaired Glucose Tolerance and Type 2 Diabetes. Int J Cardiol. 2006 Jun 16;110(2):206-11. PubMed PMID: 16297997.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between insulin resistance and left ventricular diastolic dysfunction in patients with impaired glucose tolerance and type 2 diabetes. AU - Bajraktari,Gani, AU - Koltai,Maria Szofia, AU - Ademaj,Fadil, AU - Rexhepaj,Nehat, AU - Qirko,Spiro, AU - Ndrepepa,Gjin, AU - Elezi,Shpend, Y1 - 2005/11/17/ PY - 2005/05/25/received PY - 2005/08/06/revised PY - 2005/08/20/accepted PY - 2005/11/22/pubmed PY - 2006/11/3/medline PY - 2005/11/22/entrez SP - 206 EP - 11 JF - International journal of cardiology JO - Int. J. Cardiol. VL - 110 IS - 2 N2 - AIM: The aim of this study was to explore the relationship between insulin resistance (IR) and the left ventricular diastolic function in patients with type 2 diabetes and subjects with impaired glucose tolerance (IGT). METHODS: The study included 119 subjects who underwent oral glucose tolerance test (OGTT). IR was assessed using Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) and Quantitative Insulin Sensitivity Check Index (QUICKI). Left ventricular diastolic function was assessed using trans-thoracic Doppler echocardiography. RESULTS: Based on the OGTT results, 29 subjects had normal glucose tolerance (NGT), 20 subjects had impaired glucose tolerance (IGT), and 70 patients had type 2 diabetes. There were significant differences among the patients in groups with NGT, IGT and diabetes regarding HOMA-IR (4.20 +/- 1.20 vs. 6.45 +/- 3.83 vs. 8.70 +/- 6.26; P < 0.001) and QUICKI (0.54 +/- 0.11 vs. 0.49 +/- 0.08 vs. 0.47 +/- 0.08; P < 0.001). In subjects with NGT, IGT and patients with diabetes, the pulsed Doppler transmitral variables were: E-wave (0.72 +/- 0.16 cm/s vs. 0.62 +/- 0.13 cm/s vs. 0.58 +/- 0.17 cm/s; P < 0.001), A-wave (0.61 +/- 0.13 cm/s vs. 0.62 +/- 0.11 cm/s vs. 0.71+/- 0.14 cm/s; P = 0.006) and E/A ratio (1.22 +/- 0.33 vs. 1.02 +/- 0.24 vs. 0.85 +/- 0.26; p < 0.001). The proportion of subjects with an E/A ratio <1 was 27.6% in the group with NGT, 55% in the group with IGT and 75.7% in the group with diabetes (P < 0.001). The E/A ratio correlated with HOMA-IR (r = -0.30, p = 0.001) and QUICKI (r = 0.37, p < 0.0001). Multiple linear regression model showed that IR (assessed by QUICKI) was an independent correlate of diastolic dysfunction (P = 0.034). CONCLUSIONS: In subjects with impaired glucose tolerance and patients with type 2 diabetes, insulin resistance is associated with impaired diastolic function of the left ventricle. SN - 0167-5273 UR - https://www.unboundmedicine.com/medline/citation/16297997/Relationship_between_insulin_resistance_and_left_ventricular_diastolic_dysfunction_in_patients_with_impaired_glucose_tolerance_and_type_2_diabetes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0167-5273(05)01165-4 DB - PRIME DP - Unbound Medicine ER -