Tags

Type your tag names separated by a space and hit enter

Peripheral inflammation induces up-regulation of TRPV2 expression in rat DRG.
Pain. 2005 Dec 15; 119(1-3):225-232.PAIN

Abstract

The transient receptor potential vanilloid subfamily member 2 (TRPV2) is a cation channel activated by temperatures above 52 degrees C. To analyze the contribution of TRPV2 to the development of inflammation-induced hyperalgesia, the expression of TRPV2 in primary sensory neurons was analyzed after intraplantar injection of complete Freund's adjuvant (CFA). Using specific antibodies, an increase in TRPV2-expressing neurons was identified after inflammation. TRPV2 expression is concentrated in a subset of medium-sized dorsal root ganglion neurons, independent of transient receptor potential vanilloid subfamily member 1 (TRPV1) expression. A similar distribution of TRPV2 was observed after inflammation. Intraplantar injection of nerve growth factor increased TRPV1 expression but not TRPV2, suggesting that induction of TRPV2 expression is driven by a mechanism distinct from that for TRPV1. Heat hyperalgesia assessment after chemical desensitization of TRPV1 by resiniferatoxin demonstrates a possible role for TRPV2 in inflammation at high temperatures (>56 degrees C). These results suggest that TRPV2 upregulation contributes to peripheral sensitization during inflammation and is responsible for pain hypersensitivity to noxious high temperature stimuli.

Authors+Show Affiliations

Department of Anesthesiology, Kyoto Prefectural University of Medicine, 465 Kajiicho, Kamigyo-ku, Kyoto 602-8566, Japan Department of Anesthesiology Pain Research Group, Anesthesiology Department, Lausanne University Hospital (CHUV), Lausanne, Switzerland Department of Cell Biology and Morphology (DBCM), Faculty of Biology and Medicine, Lausanne University, Lausanne, Switzerland Department of Anatomy, Kyoto Prefectural University of Medicine, Kyoto, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16298071

Citation

Shimosato, Goshun, et al. "Peripheral Inflammation Induces Up-regulation of TRPV2 Expression in Rat DRG." Pain, vol. 119, no. 1-3, 2005, pp. 225-232.
Shimosato G, Amaya F, Ueda M, et al. Peripheral inflammation induces up-regulation of TRPV2 expression in rat DRG. Pain. 2005;119(1-3):225-232.
Shimosato, G., Amaya, F., Ueda, M., Tanaka, Y., Decosterd, I., & Tanaka, M. (2005). Peripheral inflammation induces up-regulation of TRPV2 expression in rat DRG. Pain, 119(1-3), 225-232. https://doi.org/10.1016/j.pain.2005.10.002
Shimosato G, et al. Peripheral Inflammation Induces Up-regulation of TRPV2 Expression in Rat DRG. Pain. 2005 Dec 15;119(1-3):225-232. PubMed PMID: 16298071.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Peripheral inflammation induces up-regulation of TRPV2 expression in rat DRG. AU - Shimosato,Goshun, AU - Amaya,Fumimasa, AU - Ueda,Masashi, AU - Tanaka,Yoshifumi, AU - Decosterd,Isabelle, AU - Tanaka,Masaki, Y1 - 2005/11/17/ PY - 2005/05/31/received PY - 2005/08/26/revised PY - 2005/10/10/accepted PY - 2005/11/22/pubmed PY - 2006/2/16/medline PY - 2005/11/22/entrez SP - 225 EP - 232 JF - Pain JO - Pain VL - 119 IS - 1-3 N2 - The transient receptor potential vanilloid subfamily member 2 (TRPV2) is a cation channel activated by temperatures above 52 degrees C. To analyze the contribution of TRPV2 to the development of inflammation-induced hyperalgesia, the expression of TRPV2 in primary sensory neurons was analyzed after intraplantar injection of complete Freund's adjuvant (CFA). Using specific antibodies, an increase in TRPV2-expressing neurons was identified after inflammation. TRPV2 expression is concentrated in a subset of medium-sized dorsal root ganglion neurons, independent of transient receptor potential vanilloid subfamily member 1 (TRPV1) expression. A similar distribution of TRPV2 was observed after inflammation. Intraplantar injection of nerve growth factor increased TRPV1 expression but not TRPV2, suggesting that induction of TRPV2 expression is driven by a mechanism distinct from that for TRPV1. Heat hyperalgesia assessment after chemical desensitization of TRPV1 by resiniferatoxin demonstrates a possible role for TRPV2 in inflammation at high temperatures (>56 degrees C). These results suggest that TRPV2 upregulation contributes to peripheral sensitization during inflammation and is responsible for pain hypersensitivity to noxious high temperature stimuli. SN - 0304-3959 UR - https://www.unboundmedicine.com/medline/citation/16298071/Peripheral_inflammation_induces_up_regulation_of_TRPV2_expression_in_rat_DRG_ L2 - https://linkinghub.elsevier.com/retrieve/pii/00006396-200512000-00026 DB - PRIME DP - Unbound Medicine ER -