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Autoantibodies against oxidized LDL are associated with severe chest pain attacks in patients with coronary heart disease.
Free Radic Biol Med. 2005 Dec 15; 39(12):1660-5.FR

Abstract

Autoantibodies against oxidized low-density lipoprotein (oxLDL) predict the progression of atherosclerosis. Several studies have shown that oxLDL is present in atherosclerotic lesions and that several factors present in active atherosclerotic plaques can oxidatively modify LDL. Oxidation of LDL induces production of autoantibodies against oxLDL (oxLDLab) that can be measured using an EIA test. Our aim was to see whether oxLDLab are associated with severe chest pain attacks in coronary heart disease (CHD) patients. Patients having two- or three-vessel CHD, as assessed by coronary angiography, and their siblings were recruited into the study (n = 568, mean age 55.8 years, range 29.3-83.2 years). Nondiabetic patients having a history of severe chest pain attacks had significantly higher oxLDLab levels (0.611 +/- 0.56) than those who did not have a history of severe chest pain attacks (0.487 +/- 0.40) (p = 0.027), even though age, cholesterol level, body mass index, and blood pressure were similar in both groups. However, no difference was found in oxLDLab levels in diabetic patients with or without a history of severe chest pain attacks. Increased levels of oxLDL autoantibodies are associated with severe chest pain attacks in nondiabetic patients with CHD.

Authors+Show Affiliations

A.I. Virtanen Institute of Molecular Sciences, University of Kuopio, P.O. Box 1627, FIN-70211 Kuopio, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16298691

Citation

Luoma, Jukka S., et al. "Autoantibodies Against Oxidized LDL Are Associated With Severe Chest Pain Attacks in Patients With Coronary Heart Disease." Free Radical Biology & Medicine, vol. 39, no. 12, 2005, pp. 1660-5.
Luoma JS, Kareinen A, Närvänen O, et al. Autoantibodies against oxidized LDL are associated with severe chest pain attacks in patients with coronary heart disease. Free Radic Biol Med. 2005;39(12):1660-5.
Luoma, J. S., Kareinen, A., Närvänen, O., Viitanen, L., Laakso, M., & Ylä-Herttuala, S. (2005). Autoantibodies against oxidized LDL are associated with severe chest pain attacks in patients with coronary heart disease. Free Radical Biology & Medicine, 39(12), 1660-5.
Luoma JS, et al. Autoantibodies Against Oxidized LDL Are Associated With Severe Chest Pain Attacks in Patients With Coronary Heart Disease. Free Radic Biol Med. 2005 Dec 15;39(12):1660-5. PubMed PMID: 16298691.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Autoantibodies against oxidized LDL are associated with severe chest pain attacks in patients with coronary heart disease. AU - Luoma,Jukka S, AU - Kareinen,Anu, AU - Närvänen,Outi, AU - Viitanen,Laura, AU - Laakso,Markku, AU - Ylä-Herttuala,Seppo, Y1 - 2005/09/01/ PY - 2005/01/17/received PY - 2005/07/29/revised PY - 2005/08/05/accepted PY - 2005/11/22/pubmed PY - 2006/3/8/medline PY - 2005/11/22/entrez SP - 1660 EP - 5 JF - Free radical biology & medicine JO - Free Radic. Biol. Med. VL - 39 IS - 12 N2 - Autoantibodies against oxidized low-density lipoprotein (oxLDL) predict the progression of atherosclerosis. Several studies have shown that oxLDL is present in atherosclerotic lesions and that several factors present in active atherosclerotic plaques can oxidatively modify LDL. Oxidation of LDL induces production of autoantibodies against oxLDL (oxLDLab) that can be measured using an EIA test. Our aim was to see whether oxLDLab are associated with severe chest pain attacks in coronary heart disease (CHD) patients. Patients having two- or three-vessel CHD, as assessed by coronary angiography, and their siblings were recruited into the study (n = 568, mean age 55.8 years, range 29.3-83.2 years). Nondiabetic patients having a history of severe chest pain attacks had significantly higher oxLDLab levels (0.611 +/- 0.56) than those who did not have a history of severe chest pain attacks (0.487 +/- 0.40) (p = 0.027), even though age, cholesterol level, body mass index, and blood pressure were similar in both groups. However, no difference was found in oxLDLab levels in diabetic patients with or without a history of severe chest pain attacks. Increased levels of oxLDL autoantibodies are associated with severe chest pain attacks in nondiabetic patients with CHD. SN - 0891-5849 UR - https://www.unboundmedicine.com/medline/citation/16298691/Autoantibodies_against_oxidized_LDL_are_associated_with_severe_chest_pain_attacks_in_patients_with_coronary_heart_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0891-5849(05)00451-X DB - PRIME DP - Unbound Medicine ER -