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Analysis of the full-length genome of hepatitis E virus isolates obtained from wild boars in Japan.
J Gen Virol. 2005 Dec; 86(Pt 12):3321-3326.JG

Abstract

Two (2.3 %) of 87 wild-caught boars in Japan had detectable hepatitis E virus (HEV) RNA. The two boar HEV isolates (wbJTS1 and wbJYG1) obtained in the present study and a previously reported isolate (wbJSG1) whose partial sequence had been determined were sequenced over the entire genome. The wbJSG1, wbJTS1 and wbJYG1 isolates comprised 7225 or 7226 nt, excluding the poly(A) tail, and segregated into genotype 3. They differed by 8.5-11.2 % from each other and by 8.6-18.4 % from 17 reported genotype 3 HEV isolates, including one boar isolate, in the full-length sequence. When compared with 191 reported genotype 3 HEV isolates whose partial sequences were known, these three boar isolates were closer to Japanese isolates than to isolates of non-Japanese origin (89.2+/-2.6 vs 85.9+/-2.2 %; P<0.0001). A proportion of wild boars in Japan are infected with markedly heterogeneous HEV strains that are indigenous to Japan and may serve as reservoirs of HEV.

Authors+Show Affiliations

Division of Virology, Department of Infection and Immunity, Jichi Medical School, Tochigi-Ken 329-0498, Japan.Division of Virology, Department of Infection and Immunity, Jichi Medical School, Tochigi-Ken 329-0498, Japan.Division of Virology, Department of Infection and Immunity, Jichi Medical School, Tochigi-Ken 329-0498, Japan.Koyadairamura Kokuho Clinic, Tokushima-Ken 777-0302, Japan.Kawakamimura Kokuho Clinic, Yamaguchi-Ken 758-0122, Japan.Yodakubo Hospital, Nagano-Ken 386-0603, Japan.Kitaibaraki Municipal General Hospital, Ibaraki-Ken 319-1704, Japan.Kamiichi General Hospital, Toyama-Ken 930-0391, Japan.Division of Pulmonary Medicine, Department of Medicine, Jichi Medical School, Tochigi-Ken 329-0498, Japan.Division of Virology, Department of Infection and Immunity, Jichi Medical School, Tochigi-Ken 329-0498, Japan.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16298977

Citation

Nishizawa, Tsutomu, et al. "Analysis of the Full-length Genome of Hepatitis E Virus Isolates Obtained From Wild Boars in Japan." The Journal of General Virology, vol. 86, no. Pt 12, 2005, pp. 3321-3326.
Nishizawa T, Takahashi M, Endo K, et al. Analysis of the full-length genome of hepatitis E virus isolates obtained from wild boars in Japan. J Gen Virol. 2005;86(Pt 12):3321-3326.
Nishizawa, T., Takahashi, M., Endo, K., Fujiwara, S., Sakuma, N., Kawazuma, F., Sakamoto, H., Sato, Y., Bando, M., & Okamoto, H. (2005). Analysis of the full-length genome of hepatitis E virus isolates obtained from wild boars in Japan. The Journal of General Virology, 86(Pt 12), 3321-3326. https://doi.org/10.1099/vir.0.81394-0
Nishizawa T, et al. Analysis of the Full-length Genome of Hepatitis E Virus Isolates Obtained From Wild Boars in Japan. J Gen Virol. 2005;86(Pt 12):3321-3326. PubMed PMID: 16298977.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Analysis of the full-length genome of hepatitis E virus isolates obtained from wild boars in Japan. AU - Nishizawa,Tsutomu, AU - Takahashi,Masaharu, AU - Endo,Kazunori, AU - Fujiwara,Shinji, AU - Sakuma,Nobuo, AU - Kawazuma,Fumiaki, AU - Sakamoto,Hirotsugu, AU - Sato,Yukihiro, AU - Bando,Masashi, AU - Okamoto,Hiroaki, PY - 2005/11/22/pubmed PY - 2005/12/21/medline PY - 2005/11/22/entrez SP - 3321 EP - 3326 JF - The Journal of general virology JO - J Gen Virol VL - 86 IS - Pt 12 N2 - Two (2.3 %) of 87 wild-caught boars in Japan had detectable hepatitis E virus (HEV) RNA. The two boar HEV isolates (wbJTS1 and wbJYG1) obtained in the present study and a previously reported isolate (wbJSG1) whose partial sequence had been determined were sequenced over the entire genome. The wbJSG1, wbJTS1 and wbJYG1 isolates comprised 7225 or 7226 nt, excluding the poly(A) tail, and segregated into genotype 3. They differed by 8.5-11.2 % from each other and by 8.6-18.4 % from 17 reported genotype 3 HEV isolates, including one boar isolate, in the full-length sequence. When compared with 191 reported genotype 3 HEV isolates whose partial sequences were known, these three boar isolates were closer to Japanese isolates than to isolates of non-Japanese origin (89.2+/-2.6 vs 85.9+/-2.2 %; P<0.0001). A proportion of wild boars in Japan are infected with markedly heterogeneous HEV strains that are indigenous to Japan and may serve as reservoirs of HEV. SN - 0022-1317 UR - https://www.unboundmedicine.com/medline/citation/16298977/Analysis_of_the_full_length_genome_of_hepatitis_E_virus_isolates_obtained_from_wild_boars_in_Japan_ L2 - http://jgv.microbiologyresearch.org/pubmed/content/journal/jgv/10.1099/vir.0.81394-0 DB - PRIME DP - Unbound Medicine ER -