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Does long term residency near industry have an impact on the body burden of polychlorinated dibenzo-p-dioxins, furans, and polychlorinated biphenyls in older women?
Occup Environ Med. 2005 Dec; 62(12):895-901.OE

Abstract

BACKGROUND

For the retrospective study of environment and health linkages biomarkers of exposure are required. Polychlorinated dibenzo-dioxins and furans (PCDD/F) and polychlorinated biphenyls (PCBs) have been useful markers in some settings. This is the first study of PCDD/F body burden in a population based sample from the UK.

AIMS AND METHODS

The authors aimed to investigate whether long term residents close to a heavy chemical industrial complex (Teesside, UK) had a higher body burden and distinct pattern of PCDD/F and PCBs. We measured current levels of PCDD/F and PCBs in a population based sample of older women (mean 64 years, range 42-79 years). Forty women were recruited, 20 living near (zone A: 0.1-2.7 km) and 20 distant (zone C: 5-40 km) from industry during 2000-03. The authors ascertained occupational exposure to lung carcinogens, residential history, consumption of local produce, breast feeding, diet, and height and weight.

RESULTS

The mean body burden measured on lipid basis in ng/kg for the whole sample was: WHO-TEQ (PCDD/Fs): 29.9, 2378TCDD: 4.0, PCB 118:16200, PCB156: 13100. Body burdens were similar to others reported from industrialised countries, except that mean 2378TCDD was slightly higher. Mean ages, body mass index, and lifelong dietary patterns were similar in both zones. The authors found no significant difference in mean body burden levels between zones A and C before or after adjustment for covariates. All congener patterns were consistent with an urban background pattern, and there was no significant difference between congener compositions in the two zones. The TCDD body burden increased with age with accelerated increments above age 70.

CONCLUSION

Long term residency near heavy and chemical industry did not have an effect on women's body burden of PCDD/Fs and PCBs on Teesside, UK. The body burden of PCDD/F and PCBs was not a suitable biomarker for chronic, non-occupational exposure to industrial air pollution.

Authors+Show Affiliations

School of Population and Health Sciences, The Medical School, Newcastle upon Tyne, UK. Tanja.Pless-Mulloli@ncl.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16299100

Citation

Pless-Mulloli, T, et al. "Does Long Term Residency Near Industry Have an Impact On the Body Burden of Polychlorinated Dibenzo-p-dioxins, Furans, and Polychlorinated Biphenyls in Older Women?" Occupational and Environmental Medicine, vol. 62, no. 12, 2005, pp. 895-901.
Pless-Mulloli T, Edwards R, Howel D, et al. Does long term residency near industry have an impact on the body burden of polychlorinated dibenzo-p-dioxins, furans, and polychlorinated biphenyls in older women? Occup Environ Med. 2005;62(12):895-901.
Pless-Mulloli, T., Edwards, R., Howel, D., Wood, R., Paepke, O., & Herrmann, T. (2005). Does long term residency near industry have an impact on the body burden of polychlorinated dibenzo-p-dioxins, furans, and polychlorinated biphenyls in older women? Occupational and Environmental Medicine, 62(12), 895-901.
Pless-Mulloli T, et al. Does Long Term Residency Near Industry Have an Impact On the Body Burden of Polychlorinated Dibenzo-p-dioxins, Furans, and Polychlorinated Biphenyls in Older Women. Occup Environ Med. 2005;62(12):895-901. PubMed PMID: 16299100.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Does long term residency near industry have an impact on the body burden of polychlorinated dibenzo-p-dioxins, furans, and polychlorinated biphenyls in older women? AU - Pless-Mulloli,T, AU - Edwards,R, AU - Howel,D, AU - Wood,R, AU - Paepke,O, AU - Herrmann,T, PY - 2005/11/22/pubmed PY - 2006/2/4/medline PY - 2005/11/22/entrez SP - 895 EP - 901 JF - Occupational and environmental medicine JO - Occup Environ Med VL - 62 IS - 12 N2 - BACKGROUND: For the retrospective study of environment and health linkages biomarkers of exposure are required. Polychlorinated dibenzo-dioxins and furans (PCDD/F) and polychlorinated biphenyls (PCBs) have been useful markers in some settings. This is the first study of PCDD/F body burden in a population based sample from the UK. AIMS AND METHODS: The authors aimed to investigate whether long term residents close to a heavy chemical industrial complex (Teesside, UK) had a higher body burden and distinct pattern of PCDD/F and PCBs. We measured current levels of PCDD/F and PCBs in a population based sample of older women (mean 64 years, range 42-79 years). Forty women were recruited, 20 living near (zone A: 0.1-2.7 km) and 20 distant (zone C: 5-40 km) from industry during 2000-03. The authors ascertained occupational exposure to lung carcinogens, residential history, consumption of local produce, breast feeding, diet, and height and weight. RESULTS: The mean body burden measured on lipid basis in ng/kg for the whole sample was: WHO-TEQ (PCDD/Fs): 29.9, 2378TCDD: 4.0, PCB 118:16200, PCB156: 13100. Body burdens were similar to others reported from industrialised countries, except that mean 2378TCDD was slightly higher. Mean ages, body mass index, and lifelong dietary patterns were similar in both zones. The authors found no significant difference in mean body burden levels between zones A and C before or after adjustment for covariates. All congener patterns were consistent with an urban background pattern, and there was no significant difference between congener compositions in the two zones. The TCDD body burden increased with age with accelerated increments above age 70. CONCLUSION: Long term residency near heavy and chemical industry did not have an effect on women's body burden of PCDD/Fs and PCBs on Teesside, UK. The body burden of PCDD/F and PCBs was not a suitable biomarker for chronic, non-occupational exposure to industrial air pollution. SN - 1470-7926 UR - https://www.unboundmedicine.com/medline/citation/16299100/Does_long_term_residency_near_industry_have_an_impact_on_the_body_burden_of_polychlorinated_dibenzo_p_dioxins_furans_and_polychlorinated_biphenyls_in_older_women L2 - https://oem.bmj.com/lookup/pmidlookup?view=long&pmid=16299100 DB - PRIME DP - Unbound Medicine ER -