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Dorsal hippocampus involvement in trace fear conditioning with long, but not short, trace intervals in mice.
Behav Neurosci. 2005 Oct; 119(5):1396-402.BN

Abstract

Placing a "trace" interval between a warning signal and an aversive shock makes consolidation of the memory for trace conditioning hippocampus dependent. To determine the trace at which memory consolidation requires the hippocampus, mice were trained with 0-s, 1-s, 3-s, or 20-s trace intervals and tested for freezing to context and tone. Posttraining dorsal hippocampus (DH) lesions decreased context conditioning regardless of trace interval. However, DH lesions attenuated only the 20-s trace tone freezing. Like eyeblink conditioning, the DH is necessary for trace fear conditioning only at long trace intervals, but the time scale for the effective interval in fear conditioning is about 40 times longer. Manipulations that alter trace fear conditioning with short trace intervals probably do not reflect altered DH function. Given this difference in time scale along with the use of posttraining DH lesions, hippocampus dependency of trace conditioning is not related to a bridging function or response timing.

Authors+Show Affiliations

Department of Psychology, University of California, Los Angeles, 405 Hilgard Avenue, 90095 CA, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

16300446

Citation

Chowdhury, Najwa, et al. "Dorsal Hippocampus Involvement in Trace Fear Conditioning With Long, but Not Short, Trace Intervals in Mice." Behavioral Neuroscience, vol. 119, no. 5, 2005, pp. 1396-402.
Chowdhury N, Quinn JJ, Fanselow MS. Dorsal hippocampus involvement in trace fear conditioning with long, but not short, trace intervals in mice. Behav Neurosci. 2005;119(5):1396-402.
Chowdhury, N., Quinn, J. J., & Fanselow, M. S. (2005). Dorsal hippocampus involvement in trace fear conditioning with long, but not short, trace intervals in mice. Behavioral Neuroscience, 119(5), 1396-402.
Chowdhury N, Quinn JJ, Fanselow MS. Dorsal Hippocampus Involvement in Trace Fear Conditioning With Long, but Not Short, Trace Intervals in Mice. Behav Neurosci. 2005;119(5):1396-402. PubMed PMID: 16300446.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dorsal hippocampus involvement in trace fear conditioning with long, but not short, trace intervals in mice. AU - Chowdhury,Najwa, AU - Quinn,Jennifer J, AU - Fanselow,Michael S, PY - 2005/11/23/pubmed PY - 2006/2/16/medline PY - 2005/11/23/entrez SP - 1396 EP - 402 JF - Behavioral neuroscience JO - Behav Neurosci VL - 119 IS - 5 N2 - Placing a "trace" interval between a warning signal and an aversive shock makes consolidation of the memory for trace conditioning hippocampus dependent. To determine the trace at which memory consolidation requires the hippocampus, mice were trained with 0-s, 1-s, 3-s, or 20-s trace intervals and tested for freezing to context and tone. Posttraining dorsal hippocampus (DH) lesions decreased context conditioning regardless of trace interval. However, DH lesions attenuated only the 20-s trace tone freezing. Like eyeblink conditioning, the DH is necessary for trace fear conditioning only at long trace intervals, but the time scale for the effective interval in fear conditioning is about 40 times longer. Manipulations that alter trace fear conditioning with short trace intervals probably do not reflect altered DH function. Given this difference in time scale along with the use of posttraining DH lesions, hippocampus dependency of trace conditioning is not related to a bridging function or response timing. SN - 0735-7044 UR - https://www.unboundmedicine.com/medline/citation/16300446/Dorsal_hippocampus_involvement_in_trace_fear_conditioning_with_long_but_not_short_trace_intervals_in_mice_ L2 - http://content.apa.org/journals/bne/119/5/1396 DB - PRIME DP - Unbound Medicine ER -