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Understanding treatments for gout.
Am J Manag Care. 2005 Nov; 11(15 Suppl):S451-8; quiz S465-8.AJ

Abstract

Gout is one of the most readily manageable of the rheumatic diseases. This article reviews basic pathways in purine metabolism, uric acid handling, and the pathogenic mechanism of clinical gout, as well as the areas in those pathways amenable to intervention. Attention is also given to associated comorbidities, such as hyperuricemia and obesity, hypertension, hyperinsulinemia, and coronary artery disease. The significance of lifestyle modifications, such as weight loss and alcohol reduction, is discussed as an important adjunct to pharmacotherapy in gout. Current and investigational agents used in gout management are also reviewed. Finally, treatment recommendations for acute and chronic gout are suggested.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

16300459

Citation

Cannella, Amy C., and Ted R. Mikuls. "Understanding Treatments for Gout." The American Journal of Managed Care, vol. 11, no. 15 Suppl, 2005, pp. S451-8; quiz S465-8.
Cannella AC, Mikuls TR. Understanding treatments for gout. Am J Manag Care. 2005;11(15 Suppl):S451-8; quiz S465-8.
Cannella, A. C., & Mikuls, T. R. (2005). Understanding treatments for gout. The American Journal of Managed Care, 11(15 Suppl), S451-8; quiz S465-8.
Cannella AC, Mikuls TR. Understanding Treatments for Gout. Am J Manag Care. 2005;11(15 Suppl):S451-8; quiz S465-8. PubMed PMID: 16300459.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Understanding treatments for gout. AU - Cannella,Amy C, AU - Mikuls,Ted R, PY - 2005/11/23/pubmed PY - 2007/9/5/medline PY - 2005/11/23/entrez SP - S451-8; quiz S465-8 JF - The American journal of managed care JO - Am J Manag Care VL - 11 IS - 15 Suppl N2 - Gout is one of the most readily manageable of the rheumatic diseases. This article reviews basic pathways in purine metabolism, uric acid handling, and the pathogenic mechanism of clinical gout, as well as the areas in those pathways amenable to intervention. Attention is also given to associated comorbidities, such as hyperuricemia and obesity, hypertension, hyperinsulinemia, and coronary artery disease. The significance of lifestyle modifications, such as weight loss and alcohol reduction, is discussed as an important adjunct to pharmacotherapy in gout. Current and investigational agents used in gout management are also reviewed. Finally, treatment recommendations for acute and chronic gout are suggested. SN - 1936-2692 UR - https://www.unboundmedicine.com/medline/citation/16300459/Understanding_treatments_for_gout_ L2 - https://www.ajmc.com/pubMed.php?pii=3042 DB - PRIME DP - Unbound Medicine ER -