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[Inhibitory effects of alpha 1 protease inhibitor on the production of IL-1 and TNF alpha by alveolar macrophages in patients with lung cancer].
Nihon Kyobu Shikkan Gakkai Zasshi. 1992 May; 30(5):873-80.NK

Abstract

In the present study, we investigated the effect of alpha 1 protease inhibitor (alpha 1PI) on the production of interleukin-1 alpha (IL-1 alpha, ELISA), IL-1 beta (ELISA), and tumor necrosis factor alpha (TNF alpha, ELISA) by alveolar macrophages (AM) recruited by bronchoalveolar lavage (BAL) from patients with lung cancer and benign pulmonary diseases. Levels of BALF alpha 1PI were significantly increased in patients with lung cancer compared with benign pulmonary diseases. When BALF AM were cultured and stimulated by LPS (20 micrograms/ml) for 48 hours, production of IL-1 alpha and IL-1 beta was less marked in patients with lung production showed a similar tendency, but the difference between patients with lung cancer and benign pulmonary diseases was not significant. Addition of alpha 1PI to the LPS-stimulated AM culture system inhibited production of these cytokines dose-dependently. Thus, the local increase of alpha 1PI in lung cancer may act as a humoral inhibitor against the production of IL-1 and TNF by AM.

Authors+Show Affiliations

Third Department of Internal Medicine, Fukui Medical School, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

jpn

PubMed ID

1630052

Citation

Ameshima, S, et al. "[Inhibitory Effects of Alpha 1 Protease Inhibitor On the Production of IL-1 and TNF Alpha By Alveolar Macrophages in Patients With Lung Cancer]." Nihon Kyobu Shikkan Gakkai Zasshi, vol. 30, no. 5, 1992, pp. 873-80.
Ameshima S, Ishizaki T, Takahashi H, et al. [Inhibitory effects of alpha 1 protease inhibitor on the production of IL-1 and TNF alpha by alveolar macrophages in patients with lung cancer]. Nihon Kyobu Shikkan Gakkai Zasshi. 1992;30(5):873-80.
Ameshima, S., Ishizaki, T., Takahashi, H., Kishi, Y., Sasaki, F., Nakai, T., & Miyabo, S. (1992). [Inhibitory effects of alpha 1 protease inhibitor on the production of IL-1 and TNF alpha by alveolar macrophages in patients with lung cancer]. Nihon Kyobu Shikkan Gakkai Zasshi, 30(5), 873-80.
Ameshima S, et al. [Inhibitory Effects of Alpha 1 Protease Inhibitor On the Production of IL-1 and TNF Alpha By Alveolar Macrophages in Patients With Lung Cancer]. Nihon Kyobu Shikkan Gakkai Zasshi. 1992;30(5):873-80. PubMed PMID: 1630052.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Inhibitory effects of alpha 1 protease inhibitor on the production of IL-1 and TNF alpha by alveolar macrophages in patients with lung cancer]. AU - Ameshima,S, AU - Ishizaki,T, AU - Takahashi,H, AU - Kishi,Y, AU - Sasaki,F, AU - Nakai,T, AU - Miyabo,S, PY - 1992/5/1/pubmed PY - 1992/5/1/medline PY - 1992/5/1/entrez SP - 873 EP - 80 JF - Nihon Kyobu Shikkan Gakkai zasshi JO - Nihon Kyobu Shikkan Gakkai Zasshi VL - 30 IS - 5 N2 - In the present study, we investigated the effect of alpha 1 protease inhibitor (alpha 1PI) on the production of interleukin-1 alpha (IL-1 alpha, ELISA), IL-1 beta (ELISA), and tumor necrosis factor alpha (TNF alpha, ELISA) by alveolar macrophages (AM) recruited by bronchoalveolar lavage (BAL) from patients with lung cancer and benign pulmonary diseases. Levels of BALF alpha 1PI were significantly increased in patients with lung cancer compared with benign pulmonary diseases. When BALF AM were cultured and stimulated by LPS (20 micrograms/ml) for 48 hours, production of IL-1 alpha and IL-1 beta was less marked in patients with lung production showed a similar tendency, but the difference between patients with lung cancer and benign pulmonary diseases was not significant. Addition of alpha 1PI to the LPS-stimulated AM culture system inhibited production of these cytokines dose-dependently. Thus, the local increase of alpha 1PI in lung cancer may act as a humoral inhibitor against the production of IL-1 and TNF by AM. SN - 0301-1542 UR - https://www.unboundmedicine.com/medline/citation/1630052/[Inhibitory_effects_of_alpha_1_protease_inhibitor_on_the_production_of_IL_1_and_TNF_alpha_by_alveolar_macrophages_in_patients_with_lung_cancer]_ L2 - https://www.diseaseinfosearch.org/result/4334 DB - PRIME DP - Unbound Medicine ER -