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Dietary alpha-linolenic acid intake and risk of sudden cardiac death and coronary heart disease.
Circulation 2005; 112(21):3232-8Circ

Abstract

BACKGROUND

Alpha-linolenic acid, an intermediate-chain n-3 fatty acid found primarily in plants, may decrease the risk of fatal coronary heart disease (CHD) through a reduction in fatal ventricular arrhythmias and sudden cardiac death (SCD).

METHODS AND RESULTS

We prospectively examined the association between dietary intake of alpha-linolenic acid assessed via updated food-frequency questionnaires and the risk of SCD, other fatal CHD, and nonfatal myocardial infarction (MI) among 76,763 women participating in the Nurses' Health Study who were free from cancer and completed a dietary questionnaire at baseline in 1984. During 18 years of follow-up, we identified 206 SCDs, 641 other CHD deaths, and 1604 nonfatal MIs. After controlling for coronary risk factors and other fatty acids, including long-chain n-3 fatty acids, the intake of alpha-linolenic acid was inversely associated with the risk of SCD (P for trend, 0.02) but not with the risk of other fatal CHD or nonfatal MI. Compared with women in the lowest quintile of alpha-linolenic acid intake, those in the highest 2 quintiles had a 38% to 40% lower SCD risk. This inverse relation with SCD risk was linear and remained significant even among women with high intakes of long-chain n-3 fatty acids.

CONCLUSIONS

These prospective data suggest that increasing dietary intake of alpha-linolenic acid may reduce the risk of SCD but not other types of fatal CHD or nonfatal MI in women. The specificity of the association between alpha-linolenic acid and SCD supports the hypothesis that these n-3 fatty acids may have antiarrhythmic properties.

Authors+Show Affiliations

Center for Arrhythmia Prevention, Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02215-1204, USA. calbert@partners.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16301356

Citation

Albert, Christine M., et al. "Dietary Alpha-linolenic Acid Intake and Risk of Sudden Cardiac Death and Coronary Heart Disease." Circulation, vol. 112, no. 21, 2005, pp. 3232-8.
Albert CM, Oh K, Whang W, et al. Dietary alpha-linolenic acid intake and risk of sudden cardiac death and coronary heart disease. Circulation. 2005;112(21):3232-8.
Albert, C. M., Oh, K., Whang, W., Manson, J. E., Chae, C. U., Stampfer, M. J., ... Hu, F. B. (2005). Dietary alpha-linolenic acid intake and risk of sudden cardiac death and coronary heart disease. Circulation, 112(21), pp. 3232-8.
Albert CM, et al. Dietary Alpha-linolenic Acid Intake and Risk of Sudden Cardiac Death and Coronary Heart Disease. Circulation. 2005 Nov 22;112(21):3232-8. PubMed PMID: 16301356.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary alpha-linolenic acid intake and risk of sudden cardiac death and coronary heart disease. AU - Albert,Christine M, AU - Oh,Kyungwon, AU - Whang,William, AU - Manson,JoAnn E, AU - Chae,Claudia U, AU - Stampfer,Meir J, AU - Willett,Walter C, AU - Hu,Frank B, PY - 2005/11/23/pubmed PY - 2006/2/28/medline PY - 2005/11/23/entrez SP - 3232 EP - 8 JF - Circulation JO - Circulation VL - 112 IS - 21 N2 - BACKGROUND: Alpha-linolenic acid, an intermediate-chain n-3 fatty acid found primarily in plants, may decrease the risk of fatal coronary heart disease (CHD) through a reduction in fatal ventricular arrhythmias and sudden cardiac death (SCD). METHODS AND RESULTS: We prospectively examined the association between dietary intake of alpha-linolenic acid assessed via updated food-frequency questionnaires and the risk of SCD, other fatal CHD, and nonfatal myocardial infarction (MI) among 76,763 women participating in the Nurses' Health Study who were free from cancer and completed a dietary questionnaire at baseline in 1984. During 18 years of follow-up, we identified 206 SCDs, 641 other CHD deaths, and 1604 nonfatal MIs. After controlling for coronary risk factors and other fatty acids, including long-chain n-3 fatty acids, the intake of alpha-linolenic acid was inversely associated with the risk of SCD (P for trend, 0.02) but not with the risk of other fatal CHD or nonfatal MI. Compared with women in the lowest quintile of alpha-linolenic acid intake, those in the highest 2 quintiles had a 38% to 40% lower SCD risk. This inverse relation with SCD risk was linear and remained significant even among women with high intakes of long-chain n-3 fatty acids. CONCLUSIONS: These prospective data suggest that increasing dietary intake of alpha-linolenic acid may reduce the risk of SCD but not other types of fatal CHD or nonfatal MI in women. The specificity of the association between alpha-linolenic acid and SCD supports the hypothesis that these n-3 fatty acids may have antiarrhythmic properties. SN - 1524-4539 UR - https://www.unboundmedicine.com/medline/citation/16301356/Dietary_alpha_linolenic_acid_intake_and_risk_of_sudden_cardiac_death_and_coronary_heart_disease_ L2 - http://www.ahajournals.org/doi/full/10.1161/CIRCULATIONAHA.105.572008?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -