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Chronic migraine is an earlier stage of transformed migraine in adults.
Neurology. 2005 Nov 22; 65(10):1556-61.Neur

Abstract

BACKGROUND

Chronic migraine (CM) is characterized by 15 or more migraine days per month. Most adults with chronic daily headache (CDH) that evolved from migraine have < 15 days of migraine/month. They are often classified as transformed migraine (TM), a disorder not addressed in the International Headache Society classification.

OBJECTIVE

To test the hypothesis that early in the course of migraine chronification, the frequency of migraine attacks is high and that as illness progresses the frequency of nonmigraine headaches increases.

METHODS

Information was collected on 402 adults with TM and was divided into two groups. Group 1 TM had > or = 15 days of migraine/month, whereas Group 2 TM had < 15 days of migraine/month. Risk factors were modeled for number of migraine days per month using logistic regression.

RESULTS

Of 402 subjects with TM, 121 (30.1%) were in Group 1. The proportion of Group 1 subjects decreased with age, from 71% below age 30 to 22% age 60 or above. The correspondent proportion of Group 2 increased from 29 to 78%. More than 15 days of migraine per month was independently predicted by younger ages (< 40 years; p = 0.002), shorter interval from episodic to CDH (< 5 years; p = 0.003), and shorter time since the development of CDH (< 6 years; p < 0.0001).

CONCLUSION

Chronic migraine is an earlier stage of transformed migraine.

Authors+Show Affiliations

Bigal ME
Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA. mbigal@aecom.yu.edu
Rapoport AM
No affiliation info available
Sheftell FD
No affiliation info available
Tepper SJ
No affiliation info available
Lipton RB
No affiliation info available

MeSH

AdolescentAdultAge FactorsAge of OnsetAgedAnalgesicsChronic DiseaseComorbidityDisease ProgressionFemaleHeadache DisordersHumansLogistic ModelsMaleMental DisordersMiddle AgedMigraine DisordersSex FactorsSurveys and Questionnaires

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16301481

Clinical Trial Links

Efficacy of OnabotulinumtoxinA in Migraine

Citation

Bigal, M E., et al. "Chronic Migraine Is an Earlier Stage of Transformed Migraine in Adults." Neurology, vol. 65, no. 10, 2005, pp. 1556-61.
Bigal ME, Rapoport AM, Sheftell FD, et al. Chronic migraine is an earlier stage of transformed migraine in adults. Neurology. 2005;65(10):1556-61.
Bigal, M. E., Rapoport, A. M., Sheftell, F. D., Tepper, S. J., & Lipton, R. B. (2005). Chronic migraine is an earlier stage of transformed migraine in adults. Neurology, 65(10), 1556-61.
Bigal ME, et al. Chronic Migraine Is an Earlier Stage of Transformed Migraine in Adults. Neurology. 2005 Nov 22;65(10):1556-61. PubMed PMID: 16301481.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chronic migraine is an earlier stage of transformed migraine in adults. AU - Bigal,M E, AU - Rapoport,A M, AU - Sheftell,F D, AU - Tepper,S J, AU - Lipton,R B, PY - 2005/11/23/pubmed PY - 2006/2/28/medline PY - 2005/11/23/entrez SP - 1556 EP - 61 JF - Neurology JO - Neurology VL - 65 IS - 10 N2 - BACKGROUND: Chronic migraine (CM) is characterized by 15 or more migraine days per month. Most adults with chronic daily headache (CDH) that evolved from migraine have < 15 days of migraine/month. They are often classified as transformed migraine (TM), a disorder not addressed in the International Headache Society classification. OBJECTIVE: To test the hypothesis that early in the course of migraine chronification, the frequency of migraine attacks is high and that as illness progresses the frequency of nonmigraine headaches increases. METHODS: Information was collected on 402 adults with TM and was divided into two groups. Group 1 TM had > or = 15 days of migraine/month, whereas Group 2 TM had < 15 days of migraine/month. Risk factors were modeled for number of migraine days per month using logistic regression. RESULTS: Of 402 subjects with TM, 121 (30.1%) were in Group 1. The proportion of Group 1 subjects decreased with age, from 71% below age 30 to 22% age 60 or above. The correspondent proportion of Group 2 increased from 29 to 78%. More than 15 days of migraine per month was independently predicted by younger ages (< 40 years; p = 0.002), shorter interval from episodic to CDH (< 5 years; p = 0.003), and shorter time since the development of CDH (< 6 years; p < 0.0001). CONCLUSION: Chronic migraine is an earlier stage of transformed migraine. SN - 1526-632X UR - https://www.unboundmedicine.com/medline/citation/16301481/Chronic_migraine_is_an_earlier_stage_of_transformed_migraine_in_adults_ DB - PRIME DP - Unbound Medicine ER -