Tags

Type your tag names separated by a space and hit enter

Neuroprotective effect of arundic acid, an astrocyte-modulating agent, in mouse brain against MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) neurotoxicity.
Neuropharmacology. 2006 Mar; 50(3):329-44.N

Abstract

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) causes the damage of dopaminergic neurons as seen in Parkinson's disease. Oxidative stress has been as one of several pathogenic hypotheses for Parkinson's disease. Here we investigated whether arundic acid, an astrocyte-modulating agent, can protect against alterations of nitric oxide synthase (NOS) and superoxide dismutase (SOD) expression on MPTP neurotoxicity in mice, utilizing an immunohistochemistry. For this purpose, anti-tyrosine hydroxylase (TH) antibody, anti-dopamine transporter (DAT) antibody, anti-Cu/Zn-SOD antibody, anti-Mn-SOD antibody, anti-nNOS antibody, anti-eNOS antibody and anti-iNOS antibody were used. The present study showed that the arundic acid had a protective effect against MPTP-induced neuronal damage in the striatum and substantia nigra of mice. The protective effect may be, at least in part, caused by the reductions of the levels of reactive nitrogen (RNS) and oxygen species (ROS) against MPTP neurotoxicity. These results suggest that the pharmacological modulation of astrocyte may offer a novel therapeutic strategy for the treatment of Parkinson's disease. Furthermore, our results provide further evidence that a combination of nNOS inhibitors, iNOS inhibitors and free radical scavengers may be effective in the treatment of neurodegenerative diseases. Thus our present results provide valuable information for the pathogenesis of degeneration of the nigrostriatal dopaminergic neuronal pathway.

Authors+Show Affiliations

Department of Drug Metabolism and Therapeutics, Graduate School and Faculty of Pharmaceutical Sciences, The University of Tokushima, 1-78 Sho-machi, Tokushima 770-8505, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16303147

Citation

Himeda, Toshiki, et al. "Neuroprotective Effect of Arundic Acid, an Astrocyte-modulating Agent, in Mouse Brain Against MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) Neurotoxicity." Neuropharmacology, vol. 50, no. 3, 2006, pp. 329-44.
Himeda T, Kadoguchi N, Kamiyama Y, et al. Neuroprotective effect of arundic acid, an astrocyte-modulating agent, in mouse brain against MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) neurotoxicity. Neuropharmacology. 2006;50(3):329-44.
Himeda, T., Kadoguchi, N., Kamiyama, Y., Kato, H., Maegawa, H., & Araki, T. (2006). Neuroprotective effect of arundic acid, an astrocyte-modulating agent, in mouse brain against MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) neurotoxicity. Neuropharmacology, 50(3), 329-44.
Himeda T, et al. Neuroprotective Effect of Arundic Acid, an Astrocyte-modulating Agent, in Mouse Brain Against MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) Neurotoxicity. Neuropharmacology. 2006;50(3):329-44. PubMed PMID: 16303147.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neuroprotective effect of arundic acid, an astrocyte-modulating agent, in mouse brain against MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) neurotoxicity. AU - Himeda,Toshiki, AU - Kadoguchi,Naoto, AU - Kamiyama,Yuko, AU - Kato,Hiroyuki, AU - Maegawa,Hitoshi, AU - Araki,Tsutomu, Y1 - 2005/11/21/ PY - 2005/02/22/received PY - 2005/09/01/revised PY - 2005/09/21/accepted PY - 2005/11/24/pubmed PY - 2006/5/25/medline PY - 2005/11/24/entrez SP - 329 EP - 44 JF - Neuropharmacology JO - Neuropharmacology VL - 50 IS - 3 N2 - 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) causes the damage of dopaminergic neurons as seen in Parkinson's disease. Oxidative stress has been as one of several pathogenic hypotheses for Parkinson's disease. Here we investigated whether arundic acid, an astrocyte-modulating agent, can protect against alterations of nitric oxide synthase (NOS) and superoxide dismutase (SOD) expression on MPTP neurotoxicity in mice, utilizing an immunohistochemistry. For this purpose, anti-tyrosine hydroxylase (TH) antibody, anti-dopamine transporter (DAT) antibody, anti-Cu/Zn-SOD antibody, anti-Mn-SOD antibody, anti-nNOS antibody, anti-eNOS antibody and anti-iNOS antibody were used. The present study showed that the arundic acid had a protective effect against MPTP-induced neuronal damage in the striatum and substantia nigra of mice. The protective effect may be, at least in part, caused by the reductions of the levels of reactive nitrogen (RNS) and oxygen species (ROS) against MPTP neurotoxicity. These results suggest that the pharmacological modulation of astrocyte may offer a novel therapeutic strategy for the treatment of Parkinson's disease. Furthermore, our results provide further evidence that a combination of nNOS inhibitors, iNOS inhibitors and free radical scavengers may be effective in the treatment of neurodegenerative diseases. Thus our present results provide valuable information for the pathogenesis of degeneration of the nigrostriatal dopaminergic neuronal pathway. SN - 0028-3908 UR - https://www.unboundmedicine.com/medline/citation/16303147/Neuroprotective_effect_of_arundic_acid_an_astrocyte_modulating_agent_in_mouse_brain_against_MPTP__1_methyl_4_phenyl_1236_tetrahydropyridine__neurotoxicity_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0028-3908(05)00343-6 DB - PRIME DP - Unbound Medicine ER -