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Paradoxical sensation of nasal airflow in patients with common cold. Are we measuring the correct modality?
Acta Otolaryngol 2005; 125(12):1307-11AO

Abstract

CONCLUSIONS

A paradoxical relationship between objective and subjective measures of nasal obstruction exists in participants not exposed to any treatment. The sensation of nasal obstruction may be due to the amalgamation of many different nasal sensations. Improved methods for measuring nasal sensations are required to further investigate the relationship between objective and subjective measures of nasal obstruction.

OBJECTIVES

In a recent study it was shown that the subjective sensation of nasal patency increased as the nasal passages became objectively more obstructed in patients who received a placebo compared to those who received an oral decongestant. This paradoxical response may be explained as a placebo effect, i.e. patients who received a placebo may have expected to feel less obstructed. The aim of the present study was to investigate this interesting paradox by determining objective and subjective measures of nasal obstruction over time in participants not exposed to any treatment.

MATERIAL AND METHODS

A total of 60 healthy participants with common cold were recruited. Objective and subjective measures of nasal obstruction were recorded at baseline and at 1 and 2 h using posterior rhinomanometry and a visual analogue scale.

RESULTS

Objective measures demonstrated an increase in nasal obstruction over time for both nasal passages considered together and for individual nasal passages. Subjective measures demonstrated a sensation of decreased nasal obstruction over time for both nasal passages considered together and for individual nasal passages.

Authors+Show Affiliations

Common Cold Centre, Cardiff School of Biosciences, Cardiff University, Cardiff, UK.No affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16303679

Citation

Clarke, Jonathan D., and Ronald Eccles. "Paradoxical Sensation of Nasal Airflow in Patients With Common Cold. Are We Measuring the Correct Modality?" Acta Oto-laryngologica, vol. 125, no. 12, 2005, pp. 1307-11.
Clarke JD, Eccles R. Paradoxical sensation of nasal airflow in patients with common cold. Are we measuring the correct modality? Acta Otolaryngol. 2005;125(12):1307-11.
Clarke, J. D., & Eccles, R. (2005). Paradoxical sensation of nasal airflow in patients with common cold. Are we measuring the correct modality? Acta Oto-laryngologica, 125(12), pp. 1307-11.
Clarke JD, Eccles R. Paradoxical Sensation of Nasal Airflow in Patients With Common Cold. Are We Measuring the Correct Modality. Acta Otolaryngol. 2005;125(12):1307-11. PubMed PMID: 16303679.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Paradoxical sensation of nasal airflow in patients with common cold. Are we measuring the correct modality? AU - Clarke,Jonathan D, AU - Eccles,Ronald, PY - 2005/11/24/pubmed PY - 2006/3/3/medline PY - 2005/11/24/entrez SP - 1307 EP - 11 JF - Acta oto-laryngologica JO - Acta Otolaryngol. VL - 125 IS - 12 N2 - CONCLUSIONS: A paradoxical relationship between objective and subjective measures of nasal obstruction exists in participants not exposed to any treatment. The sensation of nasal obstruction may be due to the amalgamation of many different nasal sensations. Improved methods for measuring nasal sensations are required to further investigate the relationship between objective and subjective measures of nasal obstruction. OBJECTIVES: In a recent study it was shown that the subjective sensation of nasal patency increased as the nasal passages became objectively more obstructed in patients who received a placebo compared to those who received an oral decongestant. This paradoxical response may be explained as a placebo effect, i.e. patients who received a placebo may have expected to feel less obstructed. The aim of the present study was to investigate this interesting paradox by determining objective and subjective measures of nasal obstruction over time in participants not exposed to any treatment. MATERIAL AND METHODS: A total of 60 healthy participants with common cold were recruited. Objective and subjective measures of nasal obstruction were recorded at baseline and at 1 and 2 h using posterior rhinomanometry and a visual analogue scale. RESULTS: Objective measures demonstrated an increase in nasal obstruction over time for both nasal passages considered together and for individual nasal passages. Subjective measures demonstrated a sensation of decreased nasal obstruction over time for both nasal passages considered together and for individual nasal passages. SN - 0001-6489 UR - https://www.unboundmedicine.com/medline/citation/16303679/Paradoxical_sensation_of_nasal_airflow_in_patients_with_common_cold__Are_we_measuring_the_correct_modality L2 - http://www.tandfonline.com/doi/full/10.1080/00016480510043404 DB - PRIME DP - Unbound Medicine ER -