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Strong association between infection with human papillomavirus and oral and oropharyngeal squamous cell carcinoma: a population-based case-control study in southern Sweden.
Acta Otolaryngol 2005; 125(12):1337-44AO

Abstract

CONCLUSIONS

The results of this study demonstrate a strong association between infection with high-risk types of human papillomavirus (HPV) and oral and oropharyngeal squamous cell carcinoma (OOSCC), suggesting that high-risk HPV types play a key role in carcinogenesis. The estimated proportion of OOSCC cases attributable to HPV infection was 35%.

OBJECTIVE

HPV appears to have an aetiological role in OOSCC, despite the fact that the reported prevalences of HPV in both OOSCC patients and healthy individuals have varied widely. We aimed to investigate the presence and spectrum of both high- and low-risk HPVs in all consecutive cases of OOSCC in a Swedish healthcare region over a 3-year period and in population-based, matched healthy controls.

MATERIAL AND METHODS

A total of 131 patients with OOSCC were studied. Samples taken from the surface of the tumour and from the tonsillar fossa using cotton-tipped swabs were investigated, together with exfoliated cells collected using a mouthwash. Tonsillar fossa and mouthwash specimens were collected in the same way from 320 matched controls. All samples were tested for HPV DNA by nested polymerase chain reaction using the primer pairs MY09/MY11 and GP5 + /GP6+, and in positive cases the HPV type was determined by DNA sequencing.

RESULTS

Infection with high-risk HPV was shown to be a strong risk factor for OOSCC (OR = 63; 95% CI 14-480). Forty-seven (36%) of the cancer patients had > or =1 specimen that was positive for a high-risk HPV type (81% of which were HPV 16), while only 3 (0.94%) of the controls were positive for a high-risk HPV type. Seven (5.3%) of the cancer patients and 13 (4.1%) of the controls were positive for any of the mucosal, mucocutaneous or cutaneous low-risk HPV types.

Authors+Show Affiliations

Department of Laboratory Medicine, Section of Medical Microbiology, Malmö University Hospital, Lund University, Malmö, Sweden. bengt-goran.hansson@mikrobiol.mas.lu.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16303684

Citation

Hansson, Bengt Göran, et al. "Strong Association Between Infection With Human Papillomavirus and Oral and Oropharyngeal Squamous Cell Carcinoma: a Population-based Case-control Study in Southern Sweden." Acta Oto-laryngologica, vol. 125, no. 12, 2005, pp. 1337-44.
Hansson BG, Rosenquist K, Antonsson A, et al. Strong association between infection with human papillomavirus and oral and oropharyngeal squamous cell carcinoma: a population-based case-control study in southern Sweden. Acta Otolaryngol. 2005;125(12):1337-44.
Hansson, B. G., Rosenquist, K., Antonsson, A., Wennerberg, J., Schildt, E. B., Bladström, A., & Andersson, G. (2005). Strong association between infection with human papillomavirus and oral and oropharyngeal squamous cell carcinoma: a population-based case-control study in southern Sweden. Acta Oto-laryngologica, 125(12), pp. 1337-44.
Hansson BG, et al. Strong Association Between Infection With Human Papillomavirus and Oral and Oropharyngeal Squamous Cell Carcinoma: a Population-based Case-control Study in Southern Sweden. Acta Otolaryngol. 2005;125(12):1337-44. PubMed PMID: 16303684.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Strong association between infection with human papillomavirus and oral and oropharyngeal squamous cell carcinoma: a population-based case-control study in southern Sweden. AU - Hansson,Bengt Göran, AU - Rosenquist,Kerstin, AU - Antonsson,Annika, AU - Wennerberg,Johan, AU - Schildt,Elsy-Britt, AU - Bladström,Anna, AU - Andersson,Gunilla, PY - 2005/11/24/pubmed PY - 2006/3/3/medline PY - 2005/11/24/entrez SP - 1337 EP - 44 JF - Acta oto-laryngologica JO - Acta Otolaryngol. VL - 125 IS - 12 N2 - CONCLUSIONS: The results of this study demonstrate a strong association between infection with high-risk types of human papillomavirus (HPV) and oral and oropharyngeal squamous cell carcinoma (OOSCC), suggesting that high-risk HPV types play a key role in carcinogenesis. The estimated proportion of OOSCC cases attributable to HPV infection was 35%. OBJECTIVE: HPV appears to have an aetiological role in OOSCC, despite the fact that the reported prevalences of HPV in both OOSCC patients and healthy individuals have varied widely. We aimed to investigate the presence and spectrum of both high- and low-risk HPVs in all consecutive cases of OOSCC in a Swedish healthcare region over a 3-year period and in population-based, matched healthy controls. MATERIAL AND METHODS: A total of 131 patients with OOSCC were studied. Samples taken from the surface of the tumour and from the tonsillar fossa using cotton-tipped swabs were investigated, together with exfoliated cells collected using a mouthwash. Tonsillar fossa and mouthwash specimens were collected in the same way from 320 matched controls. All samples were tested for HPV DNA by nested polymerase chain reaction using the primer pairs MY09/MY11 and GP5 + /GP6+, and in positive cases the HPV type was determined by DNA sequencing. RESULTS: Infection with high-risk HPV was shown to be a strong risk factor for OOSCC (OR = 63; 95% CI 14-480). Forty-seven (36%) of the cancer patients had > or =1 specimen that was positive for a high-risk HPV type (81% of which were HPV 16), while only 3 (0.94%) of the controls were positive for a high-risk HPV type. Seven (5.3%) of the cancer patients and 13 (4.1%) of the controls were positive for any of the mucosal, mucocutaneous or cutaneous low-risk HPV types. SN - 0001-6489 UR - https://www.unboundmedicine.com/medline/citation/16303684/Strong_association_between_infection_with_human_papillomavirus_and_oral_and_oropharyngeal_squamous_cell_carcinoma:_a_population_based_case_control_study_in_southern_Sweden_ L2 - http://www.tandfonline.com/doi/full/10.1080/00016480510043945 DB - PRIME DP - Unbound Medicine ER -