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Prevalence of open-angle glaucoma in a rural south Indian population.
Invest Ophthalmol Vis Sci. 2005 Dec; 46(12):4461-7.IO

Abstract

PURPOSE

To determine the prevalence of primary open-angle glaucoma (POAG) and the associated risk factors in a rural population in southern India.

METHODS

Subjects aged 40 years or more (n = 3934) underwent a complete ophthalmic examination. Glaucoma was diagnosed according to the International Society of Geographical and Epidemiologic Ophthalmology classification.

RESULTS

Complete data were available for 3924 subjects (response rate, 81.75%). In eyes with normal suprathreshold visual fields, the mean intraocular pressure was 14.29 +/- 3.32 mm Hg (97.5th and 99.5th percentiles, 21 and 25 mm Hg, respectively). The mean vertical cup-to-disc ratio was 0.39 +/- 0.17 (97.5th and 99.5th percentiles, 0.7 and 0.8, respectively). Sixty-four subjects had definite POAG (1.62%, 9.5% CI 1.42-1.82); 30 were men and 34 were women. Subjects with POAG (59.85 +/- 10.43 years) were older (P < 0.001) than the study population (53.78 +/- 10.71 years). In only one (1.5%) person was POAG diagnosed before the study. Two (3.12%) subjects were blind due to POAG; 21 (32.81%) subjects had a presenting IOP >21 mm Hg, and 43 (67.19%) had an IOP <21 mm Hg. The mean central corneal thickness in subjects with POAG (502.82 +/- 35.29 microm) was not different from that of the normal study population (505.93 +/- 31.11 microm). No association was found with diabetes mellitus, systemic hypertension, gender, and myopia. Increasing IOP (per mm Hg) was associated with the disease (OR 1.12; 95% CI, 1.08-1.16). The odds for POAG increased with advancing age after adjustment for gender.

CONCLUSIONS

The prevalence of POAG in this population was 1.62%. The prevalence increased with age, and 98.5% were not aware of the disease.

Authors+Show Affiliations

Glaucoma Project, Vision Research Foundation, Sankara Nethralaya, Chennai, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16303934

Citation

Vijaya, Lingam, et al. "Prevalence of Open-angle Glaucoma in a Rural South Indian Population." Investigative Ophthalmology & Visual Science, vol. 46, no. 12, 2005, pp. 4461-7.
Vijaya L, George R, Paul PG, et al. Prevalence of open-angle glaucoma in a rural south Indian population. Invest Ophthalmol Vis Sci. 2005;46(12):4461-7.
Vijaya, L., George, R., Paul, P. G., Baskaran, M., Arvind, H., Raju, P., Ramesh, S. V., Kumaramanickavel, G., & McCarty, C. (2005). Prevalence of open-angle glaucoma in a rural south Indian population. Investigative Ophthalmology & Visual Science, 46(12), 4461-7.
Vijaya L, et al. Prevalence of Open-angle Glaucoma in a Rural South Indian Population. Invest Ophthalmol Vis Sci. 2005;46(12):4461-7. PubMed PMID: 16303934.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of open-angle glaucoma in a rural south Indian population. AU - Vijaya,Lingam, AU - George,Ronnie, AU - Paul,Pradeep G, AU - Baskaran,Mani, AU - Arvind,Hemamalini, AU - Raju,Prema, AU - Ramesh,S Ve, AU - Kumaramanickavel,Govindasamy, AU - McCarty,Catherine, PY - 2005/11/24/pubmed PY - 2006/1/13/medline PY - 2005/11/24/entrez SP - 4461 EP - 7 JF - Investigative ophthalmology & visual science JO - Invest. Ophthalmol. Vis. Sci. VL - 46 IS - 12 N2 - PURPOSE: To determine the prevalence of primary open-angle glaucoma (POAG) and the associated risk factors in a rural population in southern India. METHODS: Subjects aged 40 years or more (n = 3934) underwent a complete ophthalmic examination. Glaucoma was diagnosed according to the International Society of Geographical and Epidemiologic Ophthalmology classification. RESULTS: Complete data were available for 3924 subjects (response rate, 81.75%). In eyes with normal suprathreshold visual fields, the mean intraocular pressure was 14.29 +/- 3.32 mm Hg (97.5th and 99.5th percentiles, 21 and 25 mm Hg, respectively). The mean vertical cup-to-disc ratio was 0.39 +/- 0.17 (97.5th and 99.5th percentiles, 0.7 and 0.8, respectively). Sixty-four subjects had definite POAG (1.62%, 9.5% CI 1.42-1.82); 30 were men and 34 were women. Subjects with POAG (59.85 +/- 10.43 years) were older (P < 0.001) than the study population (53.78 +/- 10.71 years). In only one (1.5%) person was POAG diagnosed before the study. Two (3.12%) subjects were blind due to POAG; 21 (32.81%) subjects had a presenting IOP >21 mm Hg, and 43 (67.19%) had an IOP <21 mm Hg. The mean central corneal thickness in subjects with POAG (502.82 +/- 35.29 microm) was not different from that of the normal study population (505.93 +/- 31.11 microm). No association was found with diabetes mellitus, systemic hypertension, gender, and myopia. Increasing IOP (per mm Hg) was associated with the disease (OR 1.12; 95% CI, 1.08-1.16). The odds for POAG increased with advancing age after adjustment for gender. CONCLUSIONS: The prevalence of POAG in this population was 1.62%. The prevalence increased with age, and 98.5% were not aware of the disease. SN - 0146-0404 UR - https://www.unboundmedicine.com/medline/citation/16303934/Prevalence_of_open_angle_glaucoma_in_a_rural_south_Indian_population_ L2 - http://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.04-1529 DB - PRIME DP - Unbound Medicine ER -