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Antioxidant intake and risk of osteoporotic hip fracture in Utah: an effect modified by smoking status.
Am J Epidemiol 2006; 163(1):9-17AJ

Abstract

The role of antioxidant intake in osteoporotic hip fracture risk is uncertain and may be modified by smoking. In the Utah Study of Nutrition and Bone Health, a statewide, population-based case-control study, the authors investigated whether antioxidant intake was associated with risk of osteoporotic hip fracture and whether this association was modified by smoking status. The analyses included data on 1,215 male and female cases aged > or = 50 years who incurred a hip fracture during 1997-2001 and 1,349 age- and sex-matched controls. Diet was assessed by food frequency questionnaire. Among ever smokers, participants in the highest quintile of vitamin E intake (vs. the lowest) had a lower risk of hip fracture after adjustment for confounders (odds ratio = 0.29, 95% confidence interval (CI): 0.16, 0.52; p-trend < 0.0001). The corresponding odds ratio for beta-carotene intake was 0.39 (95% CI: 0.23, 0.68; p-trend = 0.0004), and for selenium intake it was 0.27 (95% CI: 0.12, 0.58; p-trend = 0.0003). Vitamin C intake did not have a significant graded association with hip fracture risk among ever smokers. Similar findings were obtained when an overall antioxidant intake score was used (odds ratio = 0.19, 95% CI: 0.10, 0.37; p-trend < 0.0001). No similar associations were found in never smokers. Antioxidant intake was associated with reduced risk of osteoporotic hip fracture in these elderly subjects, and the effect was strongly modified by smoking status.

Authors+Show Affiliations

Department of Nutrition and Food Sciences, Utah State University, Logan, UT, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16306312

Citation

Zhang, Jianjun, et al. "Antioxidant Intake and Risk of Osteoporotic Hip Fracture in Utah: an Effect Modified By Smoking Status." American Journal of Epidemiology, vol. 163, no. 1, 2006, pp. 9-17.
Zhang J, Munger RG, West NA, et al. Antioxidant intake and risk of osteoporotic hip fracture in Utah: an effect modified by smoking status. Am J Epidemiol. 2006;163(1):9-17.
Zhang, J., Munger, R. G., West, N. A., Cutler, D. R., Wengreen, H. J., & Corcoran, C. D. (2006). Antioxidant intake and risk of osteoporotic hip fracture in Utah: an effect modified by smoking status. American Journal of Epidemiology, 163(1), pp. 9-17.
Zhang J, et al. Antioxidant Intake and Risk of Osteoporotic Hip Fracture in Utah: an Effect Modified By Smoking Status. Am J Epidemiol. 2006 Jan 1;163(1):9-17. PubMed PMID: 16306312.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidant intake and risk of osteoporotic hip fracture in Utah: an effect modified by smoking status. AU - Zhang,Jianjun, AU - Munger,Ronald G, AU - West,Nancy A, AU - Cutler,D Richard, AU - Wengreen,Heidi J, AU - Corcoran,Christopher D, Y1 - 2005/11/23/ PY - 2005/11/25/pubmed PY - 2006/2/17/medline PY - 2005/11/25/entrez SP - 9 EP - 17 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 163 IS - 1 N2 - The role of antioxidant intake in osteoporotic hip fracture risk is uncertain and may be modified by smoking. In the Utah Study of Nutrition and Bone Health, a statewide, population-based case-control study, the authors investigated whether antioxidant intake was associated with risk of osteoporotic hip fracture and whether this association was modified by smoking status. The analyses included data on 1,215 male and female cases aged > or = 50 years who incurred a hip fracture during 1997-2001 and 1,349 age- and sex-matched controls. Diet was assessed by food frequency questionnaire. Among ever smokers, participants in the highest quintile of vitamin E intake (vs. the lowest) had a lower risk of hip fracture after adjustment for confounders (odds ratio = 0.29, 95% confidence interval (CI): 0.16, 0.52; p-trend < 0.0001). The corresponding odds ratio for beta-carotene intake was 0.39 (95% CI: 0.23, 0.68; p-trend = 0.0004), and for selenium intake it was 0.27 (95% CI: 0.12, 0.58; p-trend = 0.0003). Vitamin C intake did not have a significant graded association with hip fracture risk among ever smokers. Similar findings were obtained when an overall antioxidant intake score was used (odds ratio = 0.19, 95% CI: 0.10, 0.37; p-trend < 0.0001). No similar associations were found in never smokers. Antioxidant intake was associated with reduced risk of osteoporotic hip fracture in these elderly subjects, and the effect was strongly modified by smoking status. SN - 0002-9262 UR - https://www.unboundmedicine.com/medline/citation/16306312/Antioxidant_intake_and_risk_of_osteoporotic_hip_fracture_in_Utah:_an_effect_modified_by_smoking_status_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwj005 DB - PRIME DP - Unbound Medicine ER -