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Moderate alcohol consumption reduces risk of ischemic stroke: the Northern Manhattan Study.
Stroke 2006; 37(1):13-9S

Abstract

BACKGROUND AND PURPOSE

Moderate alcohol consumption is protective against coronary disease, but its relationship to ischemic stroke (IS) is controversial.

METHODS

Stroke-free participants > or =40 years of age identified by random-digit dialing were enrolled in a prospective cohort study between 1993 and 2001. Alcohol consumption was assessed through in-person interview and categorized as none in the past year, > or =1 drink in past month to < or =2 per day (moderate drinkers), and >2 drinks daily. Lifetime drinking was also assessed. Cox proportional hazard regression modeling was used to assess hazard ratios and their 95% CIs for the association of drinking with risk of stroke and vascular events.

RESULTS

Mean age among participants (n=3176) was 69.1+/-10.3 years; 62.8% were women, 20.8% were non-Hispanic white, 24.5% non-Hispanic black, and 52.4% were Hispanic. No alcohol in the previous year was present in 62.3%, and 32.5% drank moderately. After adjusting for other risk factors compared with those who did not drink in the past year, moderate drinkers had a reduced risk of IS (0.67; 95% CI, 0.46 to 0.99) and IS, myocardial infarction, or vascular death (0.74; 95% CI, 0.59 to 0.94). Results were similar when never-drinkers were used as referent group. Reduction in risk was seen for nonatherosclerotic IS subtypes, and results stratified by age, sex, and race-ethnicity were similar.

CONCLUSIONS

Moderate alcohol consumption is associated with decreased risk of IS in a multiethnic population. This effect is independent of other risk factors and holds for nonatherosclerotic stroke subtypes.

Authors+Show Affiliations

Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY, USA. mse13@columbia.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16306464

Citation

Elkind, Mitchell S V., et al. "Moderate Alcohol Consumption Reduces Risk of Ischemic Stroke: the Northern Manhattan Study." Stroke, vol. 37, no. 1, 2006, pp. 13-9.
Elkind MS, Sciacca R, Boden-Albala B, et al. Moderate alcohol consumption reduces risk of ischemic stroke: the Northern Manhattan Study. Stroke. 2006;37(1):13-9.
Elkind, M. S., Sciacca, R., Boden-Albala, B., Rundek, T., Paik, M. C., & Sacco, R. L. (2006). Moderate alcohol consumption reduces risk of ischemic stroke: the Northern Manhattan Study. Stroke, 37(1), pp. 13-9.
Elkind MS, et al. Moderate Alcohol Consumption Reduces Risk of Ischemic Stroke: the Northern Manhattan Study. Stroke. 2006;37(1):13-9. PubMed PMID: 16306464.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Moderate alcohol consumption reduces risk of ischemic stroke: the Northern Manhattan Study. AU - Elkind,Mitchell S V, AU - Sciacca,Robert, AU - Boden-Albala,Bernadette, AU - Rundek,Tanja, AU - Paik,Myunghee C, AU - Sacco,Ralph L, Y1 - 2005/11/23/ PY - 2005/11/25/pubmed PY - 2006/2/24/medline PY - 2005/11/25/entrez SP - 13 EP - 9 JF - Stroke JO - Stroke VL - 37 IS - 1 N2 - BACKGROUND AND PURPOSE: Moderate alcohol consumption is protective against coronary disease, but its relationship to ischemic stroke (IS) is controversial. METHODS: Stroke-free participants > or =40 years of age identified by random-digit dialing were enrolled in a prospective cohort study between 1993 and 2001. Alcohol consumption was assessed through in-person interview and categorized as none in the past year, > or =1 drink in past month to < or =2 per day (moderate drinkers), and >2 drinks daily. Lifetime drinking was also assessed. Cox proportional hazard regression modeling was used to assess hazard ratios and their 95% CIs for the association of drinking with risk of stroke and vascular events. RESULTS: Mean age among participants (n=3176) was 69.1+/-10.3 years; 62.8% were women, 20.8% were non-Hispanic white, 24.5% non-Hispanic black, and 52.4% were Hispanic. No alcohol in the previous year was present in 62.3%, and 32.5% drank moderately. After adjusting for other risk factors compared with those who did not drink in the past year, moderate drinkers had a reduced risk of IS (0.67; 95% CI, 0.46 to 0.99) and IS, myocardial infarction, or vascular death (0.74; 95% CI, 0.59 to 0.94). Results were similar when never-drinkers were used as referent group. Reduction in risk was seen for nonatherosclerotic IS subtypes, and results stratified by age, sex, and race-ethnicity were similar. CONCLUSIONS: Moderate alcohol consumption is associated with decreased risk of IS in a multiethnic population. This effect is independent of other risk factors and holds for nonatherosclerotic stroke subtypes. SN - 1524-4628 UR - https://www.unboundmedicine.com/medline/citation/16306464/Moderate_alcohol_consumption_reduces_risk_of_ischemic_stroke:_the_Northern_Manhattan_Study_ L2 - http://www.ahajournals.org/doi/full/10.1161/01.STR.0000195048.86810.5b?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -