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New genotype of avian influenza H5N1 viruses isolated from tree sparrows in China.
J Virol 2005; 79(24):15460-6JV

Abstract

The 2004 outbreaks of highly pathogenic avian influenza H5N1 disease in China led to a great poultry loss and society attention. A survey of avian influenza viruses was conducted on tree sparrows (Passer montanus) collected in China in 2004. Four viruses were isolated from free-living tree sparrows. The results of the whole-genome analysis indicated that an H5N1 virus with a new genotype is circulating among tree sparrows. The hemagglutinin and neuraminidase genes of the new genotype were derived from Gs/Gd/96-like viruses and the nuclear protein gene descended from the 2001 genotype A H5N1 viruses, while the other inner genes originated from an unknown influenza virus. In experimental infection, all four viruses were highly pathogenic to chickens but not pathogenic to ducks or mice. The four tree sparrow viruses were different from the 2003 tree sparrow strain (genotype Z) in Hong Kong. The results suggested that H5N1 viruses might be distributed widely in tree sparrows.

Authors+Show Affiliations

State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071 China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16306617

Citation

Kou, Z, et al. "New Genotype of Avian Influenza H5N1 Viruses Isolated From Tree Sparrows in China." Journal of Virology, vol. 79, no. 24, 2005, pp. 15460-6.
Kou Z, Lei FM, Yu J, et al. New genotype of avian influenza H5N1 viruses isolated from tree sparrows in China. J Virol. 2005;79(24):15460-6.
Kou, Z., Lei, F. M., Yu, J., Fan, Z. J., Yin, Z. H., Jia, C. X., ... Li, T. X. (2005). New genotype of avian influenza H5N1 viruses isolated from tree sparrows in China. Journal of Virology, 79(24), pp. 15460-6.
Kou Z, et al. New Genotype of Avian Influenza H5N1 Viruses Isolated From Tree Sparrows in China. J Virol. 2005;79(24):15460-6. PubMed PMID: 16306617.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - New genotype of avian influenza H5N1 viruses isolated from tree sparrows in China. AU - Kou,Z, AU - Lei,F M, AU - Yu,J, AU - Fan,Z J, AU - Yin,Z H, AU - Jia,C X, AU - Xiong,K J, AU - Sun,Y H, AU - Zhang,X W, AU - Wu,X M, AU - Gao,X B, AU - Li,T X, PY - 2005/11/25/pubmed PY - 2006/3/3/medline PY - 2005/11/25/entrez SP - 15460 EP - 6 JF - Journal of virology JO - J. Virol. VL - 79 IS - 24 N2 - The 2004 outbreaks of highly pathogenic avian influenza H5N1 disease in China led to a great poultry loss and society attention. A survey of avian influenza viruses was conducted on tree sparrows (Passer montanus) collected in China in 2004. Four viruses were isolated from free-living tree sparrows. The results of the whole-genome analysis indicated that an H5N1 virus with a new genotype is circulating among tree sparrows. The hemagglutinin and neuraminidase genes of the new genotype were derived from Gs/Gd/96-like viruses and the nuclear protein gene descended from the 2001 genotype A H5N1 viruses, while the other inner genes originated from an unknown influenza virus. In experimental infection, all four viruses were highly pathogenic to chickens but not pathogenic to ducks or mice. The four tree sparrow viruses were different from the 2003 tree sparrow strain (genotype Z) in Hong Kong. The results suggested that H5N1 viruses might be distributed widely in tree sparrows. SN - 0022-538X UR - https://www.unboundmedicine.com/medline/citation/16306617/New_genotype_of_avian_influenza_H5N1_viruses_isolated_from_tree_sparrows_in_China_ L2 - http://jvi.asm.org/cgi/pmidlookup?view=long&pmid=16306617 DB - PRIME DP - Unbound Medicine ER -