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Deep inspiration avoidance and airway response to methacholine: Influence of body mass index.
Can Respir J. 2005 Oct; 12(7):371-6.CR

Abstract

OBJECTIVE

To evaluate the effects of deep inspiration avoidance response to methacholine inhalation in 23 nonobese (body mass index between 18 kg/m2 and 30 kg/m2) and 27 obese (body mass index 30 kg/m2 or greater), nonatopic, nonasthmatic normal subjects.

METHODS

Each subject had four methacholine challenges. In tests A and B, the first postmethacholine forced expiratory volume in 1 s (FEV1) was measured at 30 s and 3 min postinhalation, respectively; tests C and D were single-dose tests (using the final dose of test B), with the first postmethacholine FEV1 being obtained at 3 min, without (test C) or with (test D) 20 min of deep inspiration avoidance before inhalation.

RESULTS

The mean provocative concentrations inducing a 20% fall in FEV1 on tests A and B were 80.6 mg/mL and 28.5 mg/mL (P<0.0001) in nonobese subjects, respectively, and 56.3 mg/mL and 21.5 mg/mL (P<0.0001) in obese subjects, respectively. No significant differences were observed in test A or B between control and obese subjects. Mean falls in FEV1 for tests C and D were 20.3% and 40.0% (P=0.0003) in nonobese subjects, respectively, and 18.5% and 23.6% (P>0.05) in obese subjects, respectively.

CONCLUSIONS

As previously observed in patients with asthma, the present study found that nonasthmatic obese subjects had no increase in the fall in FEV1 after deep inspiration avoidance before methacholine, whereas nonobese subjects did, suggesting that obesity alters airway function. No significant changes were found between groups for symptom perception.

Authors+Show Affiliations

Unité de recherche en pneumologie, Institut de cardiologie et de pneumologie de l'Université Laval, Hôpital Laval, Québec City. lpboulet@med.ulaval.caNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16307028

Citation

Boulet, Louis-Philippe, et al. "Deep Inspiration Avoidance and Airway Response to Methacholine: Influence of Body Mass Index." Canadian Respiratory Journal, vol. 12, no. 7, 2005, pp. 371-6.
Boulet LP, Turcotte H, Boulet G, et al. Deep inspiration avoidance and airway response to methacholine: Influence of body mass index. Can Respir J. 2005;12(7):371-6.
Boulet, L. P., Turcotte, H., Boulet, G., Simard, B., & Robichaud, P. (2005). Deep inspiration avoidance and airway response to methacholine: Influence of body mass index. Canadian Respiratory Journal, 12(7), 371-6.
Boulet LP, et al. Deep Inspiration Avoidance and Airway Response to Methacholine: Influence of Body Mass Index. Can Respir J. 2005;12(7):371-6. PubMed PMID: 16307028.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Deep inspiration avoidance and airway response to methacholine: Influence of body mass index. AU - Boulet,Louis-Philippe, AU - Turcotte,Hélène, AU - Boulet,Geneviève, AU - Simard,Barbara, AU - Robichaud,Patricia, PY - 2005/11/25/pubmed PY - 2006/1/19/medline PY - 2005/11/25/entrez SP - 371 EP - 6 JF - Canadian respiratory journal JO - Can. Respir. J. VL - 12 IS - 7 N2 - OBJECTIVE: To evaluate the effects of deep inspiration avoidance response to methacholine inhalation in 23 nonobese (body mass index between 18 kg/m2 and 30 kg/m2) and 27 obese (body mass index 30 kg/m2 or greater), nonatopic, nonasthmatic normal subjects. METHODS: Each subject had four methacholine challenges. In tests A and B, the first postmethacholine forced expiratory volume in 1 s (FEV1) was measured at 30 s and 3 min postinhalation, respectively; tests C and D were single-dose tests (using the final dose of test B), with the first postmethacholine FEV1 being obtained at 3 min, without (test C) or with (test D) 20 min of deep inspiration avoidance before inhalation. RESULTS: The mean provocative concentrations inducing a 20% fall in FEV1 on tests A and B were 80.6 mg/mL and 28.5 mg/mL (P<0.0001) in nonobese subjects, respectively, and 56.3 mg/mL and 21.5 mg/mL (P<0.0001) in obese subjects, respectively. No significant differences were observed in test A or B between control and obese subjects. Mean falls in FEV1 for tests C and D were 20.3% and 40.0% (P=0.0003) in nonobese subjects, respectively, and 18.5% and 23.6% (P>0.05) in obese subjects, respectively. CONCLUSIONS: As previously observed in patients with asthma, the present study found that nonasthmatic obese subjects had no increase in the fall in FEV1 after deep inspiration avoidance before methacholine, whereas nonobese subjects did, suggesting that obesity alters airway function. No significant changes were found between groups for symptom perception. SN - 1198-2241 UR - https://www.unboundmedicine.com/medline/citation/16307028/Deep_inspiration_avoidance_and_airway_response_to_methacholine:_Influence_of_body_mass_index_ L2 - https://dx.doi.org/10.1155/2005/517548 DB - PRIME DP - Unbound Medicine ER -