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Activity of five quinolones, three macrolides and telithromycin against 12 Haemophilus influenzae strains with different resistance phenotypes.
Clin Microbiol Infect. 2005 Dec; 11(12):1040-4.CM

Abstract

Gemifloxacin MICs for 12 Haemophilus influenzae strains with different resistance phenotypes were 0.001-0.015 mg/L. Gemifloxacin was bactericidal against all 12 strains after 24 h at 2 x MIC. Ciprofloxacin, levofloxacin, gatifloxacin and moxifloxacin had MICs of 0.008-0.03 mg/L and similar kill kinetics. Macrolides and telithromycin had unimodal MICs (1.0-8.0 mg/L), except for two strains without efflux systems (0.0125-0.5 mg/L) and two with efflux systems and ribosomal protein mutations (> 64.0 mg/L), and were bactericidal against eight to ten strains tested at 2 x MIC after 24 h.

Authors+Show Affiliations

Department of Pathology, Hershey Medical Center, Hershey, PA 17033, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16307562

Citation

Pankuch, G A., et al. "Activity of Five Quinolones, Three Macrolides and Telithromycin Against 12 Haemophilus Influenzae Strains With Different Resistance Phenotypes." Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases, vol. 11, no. 12, 2005, pp. 1040-4.
Pankuch GA, Lin G, Appelbaum PC. Activity of five quinolones, three macrolides and telithromycin against 12 Haemophilus influenzae strains with different resistance phenotypes. Clin Microbiol Infect. 2005;11(12):1040-4.
Pankuch, G. A., Lin, G., & Appelbaum, P. C. (2005). Activity of five quinolones, three macrolides and telithromycin against 12 Haemophilus influenzae strains with different resistance phenotypes. Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases, 11(12), 1040-4.
Pankuch GA, Lin G, Appelbaum PC. Activity of Five Quinolones, Three Macrolides and Telithromycin Against 12 Haemophilus Influenzae Strains With Different Resistance Phenotypes. Clin Microbiol Infect. 2005;11(12):1040-4. PubMed PMID: 16307562.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Activity of five quinolones, three macrolides and telithromycin against 12 Haemophilus influenzae strains with different resistance phenotypes. AU - Pankuch,G A, AU - Lin,G, AU - Appelbaum,P C, PY - 2005/11/26/pubmed PY - 2006/1/21/medline PY - 2005/11/26/entrez SP - 1040 EP - 4 JF - Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases JO - Clin Microbiol Infect VL - 11 IS - 12 N2 - Gemifloxacin MICs for 12 Haemophilus influenzae strains with different resistance phenotypes were 0.001-0.015 mg/L. Gemifloxacin was bactericidal against all 12 strains after 24 h at 2 x MIC. Ciprofloxacin, levofloxacin, gatifloxacin and moxifloxacin had MICs of 0.008-0.03 mg/L and similar kill kinetics. Macrolides and telithromycin had unimodal MICs (1.0-8.0 mg/L), except for two strains without efflux systems (0.0125-0.5 mg/L) and two with efflux systems and ribosomal protein mutations (> 64.0 mg/L), and were bactericidal against eight to ten strains tested at 2 x MIC after 24 h. SN - 1198-743X UR - https://www.unboundmedicine.com/medline/citation/16307562/Activity_of_five_quinolones_three_macrolides_and_telithromycin_against_12_Haemophilus_influenzae_strains_with_different_resistance_phenotypes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1198-743X(14)62403-4 DB - PRIME DP - Unbound Medicine ER -