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Maternal plasma adiponectin concentrations at 24 to 31 weeks of gestation: negative association with gestational diabetes mellitus.
Nutrition. 2005 Nov-Dec; 21(11-12):1095-9.N

Abstract

OBJECTIVE

Adiponectin is an adipocyte-derived hormone with antidiabetic, antiatherosclerotic, and antiinflammatory properties. This study investigated the relations between maternal adiponectin concentration and gestational diabetes mellitus (GDM) and other metabolic parameters during midpregnancy.

METHODS

Two-hour 75-g oral glucose tolerance tests were performed in 253 pregnant women at 24 to 31 wk of gestation. Two hundred nineteen who had normal glucose tolerance (NGT) and 34 women who had GDM and their newborns were investigated. Fasting maternal blood samples were drawn to determine plasma concentrations of adiponectin, glucose, insulin, C-peptide, free fatty acid, and blood lipids. Blood samples at 1 and 2 h after an oral glucose load were obtained to measure plasma glucose, insulin, and C-peptide concentrations.

RESULTS

Plasma adiponectin concentrations were significantly lower in women who had GDM than in those who had NGT (P = 0.014). Maternal age, body mass index (before pregnancy and at blood collection), and plasma level of free fatty acid were significantly greater in those who had GDM than in those who had NGT. Logistic regression analysis showed that maternal adiponectin level and GDM were significantly correlated (P = 0.043), but that the correlation became weaker (P = 0.116) after adjusting for maternal body mass index and plasma level of free fatty acid before pregnancy. In the NGT group, maternal adiponectin concentrations were significantly negatively correlated with plasma fasting insulin, fasting C-peptide, fasting C-peptide/fasting glucose ratio, 2-h glucose, triacylglycerol, and maternal body mass index and positively correlated with high-density lipoprotein cholesterol concentration. In the GDM group, maternal adiponectin level was negatively correlated with neonatal birth weight.

CONCLUSIONS

Midpregnancy hypoadiponectinemia may be associated with a higher risk of GDM.

Authors+Show Affiliations

Department of Food Science, Yuanpei University of Science and Technology, Hsinchu, Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16308131

Citation

Tsai, Po-Jung, et al. "Maternal Plasma Adiponectin Concentrations at 24 to 31 Weeks of Gestation: Negative Association With Gestational Diabetes Mellitus." Nutrition (Burbank, Los Angeles County, Calif.), vol. 21, no. 11-12, 2005, pp. 1095-9.
Tsai PJ, Yu CH, Hsu SP, et al. Maternal plasma adiponectin concentrations at 24 to 31 weeks of gestation: negative association with gestational diabetes mellitus. Nutrition. 2005;21(11-12):1095-9.
Tsai, P. J., Yu, C. H., Hsu, S. P., Lee, Y. H., Huang, I. T., Ho, S. C., & Chu, C. H. (2005). Maternal plasma adiponectin concentrations at 24 to 31 weeks of gestation: negative association with gestational diabetes mellitus. Nutrition (Burbank, Los Angeles County, Calif.), 21(11-12), 1095-9.
Tsai PJ, et al. Maternal Plasma Adiponectin Concentrations at 24 to 31 Weeks of Gestation: Negative Association With Gestational Diabetes Mellitus. Nutrition. 2005;21(11-12):1095-9. PubMed PMID: 16308131.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maternal plasma adiponectin concentrations at 24 to 31 weeks of gestation: negative association with gestational diabetes mellitus. AU - Tsai,Po-Jung, AU - Yu,Chun-Hsien, AU - Hsu,Shih-Penn, AU - Lee,Yu-Hsiang, AU - Huang,I-Tsan, AU - Ho,Su-Chen, AU - Chu,Chun-Hong, PY - 2004/11/17/received PY - 2005/03/27/accepted PY - 2005/11/26/pubmed PY - 2006/3/17/medline PY - 2005/11/26/entrez SP - 1095 EP - 9 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 21 IS - 11-12 N2 - OBJECTIVE: Adiponectin is an adipocyte-derived hormone with antidiabetic, antiatherosclerotic, and antiinflammatory properties. This study investigated the relations between maternal adiponectin concentration and gestational diabetes mellitus (GDM) and other metabolic parameters during midpregnancy. METHODS: Two-hour 75-g oral glucose tolerance tests were performed in 253 pregnant women at 24 to 31 wk of gestation. Two hundred nineteen who had normal glucose tolerance (NGT) and 34 women who had GDM and their newborns were investigated. Fasting maternal blood samples were drawn to determine plasma concentrations of adiponectin, glucose, insulin, C-peptide, free fatty acid, and blood lipids. Blood samples at 1 and 2 h after an oral glucose load were obtained to measure plasma glucose, insulin, and C-peptide concentrations. RESULTS: Plasma adiponectin concentrations were significantly lower in women who had GDM than in those who had NGT (P = 0.014). Maternal age, body mass index (before pregnancy and at blood collection), and plasma level of free fatty acid were significantly greater in those who had GDM than in those who had NGT. Logistic regression analysis showed that maternal adiponectin level and GDM were significantly correlated (P = 0.043), but that the correlation became weaker (P = 0.116) after adjusting for maternal body mass index and plasma level of free fatty acid before pregnancy. In the NGT group, maternal adiponectin concentrations were significantly negatively correlated with plasma fasting insulin, fasting C-peptide, fasting C-peptide/fasting glucose ratio, 2-h glucose, triacylglycerol, and maternal body mass index and positively correlated with high-density lipoprotein cholesterol concentration. In the GDM group, maternal adiponectin level was negatively correlated with neonatal birth weight. CONCLUSIONS: Midpregnancy hypoadiponectinemia may be associated with a higher risk of GDM. SN - 0899-9007 UR - https://www.unboundmedicine.com/medline/citation/16308131/Maternal_plasma_adiponectin_concentrations_at_24_to_31_weeks_of_gestation:_negative_association_with_gestational_diabetes_mellitus_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0899-9007(05)00223-6 DB - PRIME DP - Unbound Medicine ER -