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Prospective study of resting energy expenditure changes in head and neck cancer patients treated with chemoradiotherapy measured by indirect calorimetry.
Nutrition. 2005 Nov-Dec; 21(11-12):1107-12.N

Abstract

OBJECTIVE

The prevalence of malnutrition is high in patients with head and neck cancer due to tumor location and coadjuvant treatment. We studied changes in resting energy expenditure (REE) during treatment with chemoradiotherapy and compared the measured REE by indirect calorimetry (IC) with the value estimated by the Harris-Benedict (HB) formula.

METHODS

Eighteen patients with head and neck cancer (15 men and 3 women, mean age 57 +/- 10.7 y, age range 30-71 y) entered the study. All patients were treated with radiotherapy (70.8 +/- 1 Gy, range 70-72) and received 37.4 +/- 3.5 fractions (range 32-42) and concurrent chemotherapy with cisplatinum (absolute doses of 400 to 1000 mg). Nutrition assessment included anthropometry (body mass index, triceps skinfold thickness, subscapular skinfold thickness, midarm circumference, and midarm muscle circumference) and tetrapolar bioimpedance (Holtain BC). The IC (kcal/24 h; Deltatrac II MBM-200) was performed after an overnight fast. Measurements were done before treatment, at weeks 2, 4, and 6 of treatment, at the end of treatment, and 2 wk after treatment.

RESULTS

Body mass index decreased during treatment from 24.7 +/- 4.4 kg/m(2) (range 16.9-31.4) to 22.3 +/- 4.2 kg/m(2) (range 15.1-29.6). REE (kcal/24 h) changed significantly during treatment (IC P < 0.05, HB formula P < 0.001). REE measured by IC appeared as a U-shaped curve, but REE estimated by the HB formula decreased during treatment. The HB underestimated REE measurements compared with IC. These differences were statistically significant before treatment, at the end of treatment, and 2 wk after treatment (P < 0.05) and showed a limited clinical agreement with the Bland-Altman method.

CONCLUSIONS

REE measured by IC significantly changed during chemoradiotherapy. It was higher before treatment, at the end of treatment, and 2 wk after treatment. The HB formula underestimated REE in these patients. IC is a suitable method for measuring REE in this cohort of patients.

Authors+Show Affiliations

Nutrition Unit, Hospital General Universitario Gregorio Marañón, Madrid, Spain. pgarciap.hgugm@salud.madrid.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16308133

Citation

García-Peris, Pilar, et al. "Prospective Study of Resting Energy Expenditure Changes in Head and Neck Cancer Patients Treated With Chemoradiotherapy Measured By Indirect Calorimetry." Nutrition (Burbank, Los Angeles County, Calif.), vol. 21, no. 11-12, 2005, pp. 1107-12.
García-Peris P, Lozano MA, Velasco C, et al. Prospective study of resting energy expenditure changes in head and neck cancer patients treated with chemoradiotherapy measured by indirect calorimetry. Nutrition. 2005;21(11-12):1107-12.
García-Peris, P., Lozano, M. A., Velasco, C., de La Cuerda, C., Iriondo, T., Bretón, I., Camblor, M., & Navarro, C. (2005). Prospective study of resting energy expenditure changes in head and neck cancer patients treated with chemoradiotherapy measured by indirect calorimetry. Nutrition (Burbank, Los Angeles County, Calif.), 21(11-12), 1107-12.
García-Peris P, et al. Prospective Study of Resting Energy Expenditure Changes in Head and Neck Cancer Patients Treated With Chemoradiotherapy Measured By Indirect Calorimetry. Nutrition. 2005 Nov-Dec;21(11-12):1107-12. PubMed PMID: 16308133.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prospective study of resting energy expenditure changes in head and neck cancer patients treated with chemoradiotherapy measured by indirect calorimetry. AU - García-Peris,Pilar, AU - Lozano,Miguel Angel, AU - Velasco,Cristina, AU - de La Cuerda,Cristina, AU - Iriondo,Teresa, AU - Bretón,Irene, AU - Camblor,Miguel, AU - Navarro,Carlos, PY - 2005/01/20/received PY - 2005/03/30/accepted PY - 2005/11/26/pubmed PY - 2006/3/17/medline PY - 2005/11/26/entrez SP - 1107 EP - 12 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 21 IS - 11-12 N2 - OBJECTIVE: The prevalence of malnutrition is high in patients with head and neck cancer due to tumor location and coadjuvant treatment. We studied changes in resting energy expenditure (REE) during treatment with chemoradiotherapy and compared the measured REE by indirect calorimetry (IC) with the value estimated by the Harris-Benedict (HB) formula. METHODS: Eighteen patients with head and neck cancer (15 men and 3 women, mean age 57 +/- 10.7 y, age range 30-71 y) entered the study. All patients were treated with radiotherapy (70.8 +/- 1 Gy, range 70-72) and received 37.4 +/- 3.5 fractions (range 32-42) and concurrent chemotherapy with cisplatinum (absolute doses of 400 to 1000 mg). Nutrition assessment included anthropometry (body mass index, triceps skinfold thickness, subscapular skinfold thickness, midarm circumference, and midarm muscle circumference) and tetrapolar bioimpedance (Holtain BC). The IC (kcal/24 h; Deltatrac II MBM-200) was performed after an overnight fast. Measurements were done before treatment, at weeks 2, 4, and 6 of treatment, at the end of treatment, and 2 wk after treatment. RESULTS: Body mass index decreased during treatment from 24.7 +/- 4.4 kg/m(2) (range 16.9-31.4) to 22.3 +/- 4.2 kg/m(2) (range 15.1-29.6). REE (kcal/24 h) changed significantly during treatment (IC P < 0.05, HB formula P < 0.001). REE measured by IC appeared as a U-shaped curve, but REE estimated by the HB formula decreased during treatment. The HB underestimated REE measurements compared with IC. These differences were statistically significant before treatment, at the end of treatment, and 2 wk after treatment (P < 0.05) and showed a limited clinical agreement with the Bland-Altman method. CONCLUSIONS: REE measured by IC significantly changed during chemoradiotherapy. It was higher before treatment, at the end of treatment, and 2 wk after treatment. The HB formula underestimated REE in these patients. IC is a suitable method for measuring REE in this cohort of patients. SN - 0899-9007 UR - https://www.unboundmedicine.com/medline/citation/16308133/Prospective_study_of_resting_energy_expenditure_changes_in_head_and_neck_cancer_patients_treated_with_chemoradiotherapy_measured_by_indirect_calorimetry_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0899-9007(05)00220-0 DB - PRIME DP - Unbound Medicine ER -