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Aetiology of community-acquired pneumonia: serological results of a paediatric survey.
Scand J Infect Dis. 2005; 37(11-12):806-12.SJ

Abstract

Serological methods are routinely used in the diagnosis of viral and atypical bacterial respiratory infections. Recently, they have also been applied to typical bacteria, such as Streptococcus pneumoniae. The aim of this study was to determine the aetiology of paediatric community-acquired pneumonia (CAP) in both ambulatory and hospitalized patients, by using antibody assays. During a 15-month prospective surveillance, paired sera were studied for antibodies to 14 microbes in 101 children with symptoms of acute infection and infiltrates compatible with pneumonia on chest radiographs. A potential causative agent was detected in 66 (65%) patients. Evidence of bacterial, viral and mixed viral-bacterial infection was demonstrated in 44%, 42% and 20% of the CAP cases, respectively. The most commonly found agents included Mycoplasma pneumoniae (27%), Pneumococcus (18%) and respiratory syncytial virus (17%). Human metapneumovirus (hMPV) was detected in 5 (5%) children. Pneumococcal infections were evenly distributed among the age groups studied. Our results confirm the role of S. pneumoniae in paediatric CAP at all ages, those of M. pneumoniae at >2 y of age and emphasize the emerging role of hMPV. The high proportion of mixed viral-bacterial infections highlights the need to treat all children with CAP with antibiotics.

Authors+Show Affiliations

Department of Paediatrics, School of Medicine DPMSC, University of Udine, Udine, Italy. max.don@libero.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16308213

Citation

Don, Massimiliano, et al. "Aetiology of Community-acquired Pneumonia: Serological Results of a Paediatric Survey." Scandinavian Journal of Infectious Diseases, vol. 37, no. 11-12, 2005, pp. 806-12.
Don M, Fasoli L, Paldanius M, et al. Aetiology of community-acquired pneumonia: serological results of a paediatric survey. Scand J Infect Dis. 2005;37(11-12):806-12.
Don, M., Fasoli, L., Paldanius, M., Vainionpää, R., Kleemola, M., Räty, R., Leinonen, M., Korppi, M., Tenore, A., & Canciani, M. (2005). Aetiology of community-acquired pneumonia: serological results of a paediatric survey. Scandinavian Journal of Infectious Diseases, 37(11-12), 806-12.
Don M, et al. Aetiology of Community-acquired Pneumonia: Serological Results of a Paediatric Survey. Scand J Infect Dis. 2005;37(11-12):806-12. PubMed PMID: 16308213.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Aetiology of community-acquired pneumonia: serological results of a paediatric survey. AU - Don,Massimiliano, AU - Fasoli,Lolita, AU - Paldanius,Mika, AU - Vainionpää,Raija, AU - Kleemola,Marjaana, AU - Räty,Riitta, AU - Leinonen,Maija, AU - Korppi,Matti, AU - Tenore,Alfred, AU - Canciani,Mario, PY - 2005/11/26/pubmed PY - 2006/1/26/medline PY - 2005/11/26/entrez SP - 806 EP - 12 JF - Scandinavian journal of infectious diseases JO - Scand J Infect Dis VL - 37 IS - 11-12 N2 - Serological methods are routinely used in the diagnosis of viral and atypical bacterial respiratory infections. Recently, they have also been applied to typical bacteria, such as Streptococcus pneumoniae. The aim of this study was to determine the aetiology of paediatric community-acquired pneumonia (CAP) in both ambulatory and hospitalized patients, by using antibody assays. During a 15-month prospective surveillance, paired sera were studied for antibodies to 14 microbes in 101 children with symptoms of acute infection and infiltrates compatible with pneumonia on chest radiographs. A potential causative agent was detected in 66 (65%) patients. Evidence of bacterial, viral and mixed viral-bacterial infection was demonstrated in 44%, 42% and 20% of the CAP cases, respectively. The most commonly found agents included Mycoplasma pneumoniae (27%), Pneumococcus (18%) and respiratory syncytial virus (17%). Human metapneumovirus (hMPV) was detected in 5 (5%) children. Pneumococcal infections were evenly distributed among the age groups studied. Our results confirm the role of S. pneumoniae in paediatric CAP at all ages, those of M. pneumoniae at >2 y of age and emphasize the emerging role of hMPV. The high proportion of mixed viral-bacterial infections highlights the need to treat all children with CAP with antibiotics. SN - 0036-5548 UR - https://www.unboundmedicine.com/medline/citation/16308213/Aetiology_of_community_acquired_pneumonia:_serological_results_of_a_paediatric_survey_ L2 - https://www.tandfonline.com/doi/full/10.1080/00365540500262435 DB - PRIME DP - Unbound Medicine ER -