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Extraction, hemisynthesis, and synthesis of canthin-6-one analogues. Evaluation of their antifungal activities.
J Nat Prod. 2005 Nov; 68(11):1581-7.JN

Abstract

Zanthoxylum chiloperone var. angustifolium was investigated. Alkaloids 1-3 from the canthin-6-one series were characterized. Derivatives 7-28 were prepared by hemisynthesis or total synthesis. All compounds were tested for in vitro antifungal activities against five pathogenic fungal strains. Analogues of canthin-6-one did not show better antifungal activities.

Authors+Show Affiliations

Soriano-Agatón F
Laboratoire de Pharmacognosie Associé au CNRS (UMR 8076, BioCIS), Centre d'Etudes Pharmaceutiques, Université Paris-Sud 11, 5 Rue Jean-Baptiste Clément, 92296 Châtenay-Malabry, France.
Lagoutte D
No affiliation info available
Poupon E
No affiliation info available
Roblot F
No affiliation info available
Fournet A
No affiliation info available
Gantier JC
No affiliation info available
Hocquemiller R
No affiliation info available

MeSH

AlkaloidsAntifungal AgentsAspergillus fumigatusCandida albicansCarbolinesCryptococcus neoformansDrug Evaluation, PreclinicalIndole AlkaloidsIndolesMicrobial Sensitivity TestsMolecular StructureNaphthyridinesPlants, MedicinalSaccharomyces cerevisiaeStructure-Activity RelationshipTrichophytonZanthoxylum

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16309303

Citation

Soriano-Agatón, Flor, et al. "Extraction, Hemisynthesis, and Synthesis of Canthin-6-one Analogues. Evaluation of Their Antifungal Activities." Journal of Natural Products, vol. 68, no. 11, 2005, pp. 1581-7.
Soriano-Agatón F, Lagoutte D, Poupon E, et al. Extraction, hemisynthesis, and synthesis of canthin-6-one analogues. Evaluation of their antifungal activities. J Nat Prod. 2005;68(11):1581-7.
Soriano-Agatón, F., Lagoutte, D., Poupon, E., Roblot, F., Fournet, A., Gantier, J. C., & Hocquemiller, R. (2005). Extraction, hemisynthesis, and synthesis of canthin-6-one analogues. Evaluation of their antifungal activities. Journal of Natural Products, 68(11), 1581-7.
Soriano-Agatón F, et al. Extraction, Hemisynthesis, and Synthesis of Canthin-6-one Analogues. Evaluation of Their Antifungal Activities. J Nat Prod. 2005;68(11):1581-7. PubMed PMID: 16309303.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Extraction, hemisynthesis, and synthesis of canthin-6-one analogues. Evaluation of their antifungal activities. AU - Soriano-Agatón,Flor, AU - Lagoutte,Delphine, AU - Poupon,Erwan, AU - Roblot,François, AU - Fournet,Alain, AU - Gantier,Jean-Charles, AU - Hocquemiller,Reynald, PY - 2005/11/29/pubmed PY - 2005/12/29/medline PY - 2005/11/29/entrez SP - 1581 EP - 7 JF - Journal of natural products JO - J Nat Prod VL - 68 IS - 11 N2 - Zanthoxylum chiloperone var. angustifolium was investigated. Alkaloids 1-3 from the canthin-6-one series were characterized. Derivatives 7-28 were prepared by hemisynthesis or total synthesis. All compounds were tested for in vitro antifungal activities against five pathogenic fungal strains. Analogues of canthin-6-one did not show better antifungal activities. SN - 0163-3864 UR - https://www.unboundmedicine.com/medline/citation/16309303/Extraction_hemisynthesis_and_synthesis_of_canthin_6_one_analogues__Evaluation_of_their_antifungal_activities_ DB - PRIME DP - Unbound Medicine ER -